Theory of thoughts (ToM), or the capacity to attribute psychological states to oneself and others, is a core factor of social cognition (SC). Even although its significance for social functioning usually, and neurodevelopmental problems (NDDs), specifically, is nicely established, the hyperlinks between ToM and different cognitive features usually are not. Especially the familial underpinnings of such hyperlinks stay unclear.
Using a co-twin management design, we examined N = 311 twins (imply age M = 17.19 years, 47% females) recognized with autism spectrum dysfunction (ASD), consideration-deficit/hyperactivity dysfunction (ADHD), different NDDs, or sometimes growing people. We used the Reading the Mind in the Eyes Test to operationalize ToM, the Fragmented Pictures Test for central coherence (CC), the Tower Test for govt functioning (EF), and the normal capacity index in the Wechsler Intelligence Scales for IQ.
In the linear regressions, weak CC and a decrease IQ have been related to a decreased ToM capacity throughout pairs. Female intercourse and larger age have been robustly related to elevated ToM capacity, whereas EF was not related to ToM. In the inside-pair analyses, the place unmeasured familial confounders are implicitly adjusted, the associations between ToM and different cognitive features, have been attenuated and the affiliation with CC was non-important.
The end result means that familial elements shared by the twins, reminiscent of genetic and shared setting, affect the affiliation between CC, IQ, and ToM. Future research want to incorporate a bigger pattern of monozygotic twins, who’re genetically similar, with the intention to draw extra agency conclusions relating to the affect of familial elements, and to distinguish between shared environmental and genetic results on the associations between cognitive features.
Safety and Efficacy of Intravenous Ferric Derisomaltose Compared to Iron Sucrose for Iron Deficiency Anemia in Patients with Chronic Kidney Disease With and Without Heart Failure
Ferric derisomaltose (FDI) is an intravenous (IV) excessive-dose iron formulation authorised in the US for the remedy of iron deficiency anemia in adults who’re illiberal of/have had an unsatisfactory response to oral iron, or who’ve non-dialysis-dependent continual kidney illness (NDD-CKD). FERWON-NEPHRO was a randomized, open-label, multicenter scientific trial evaluating the security and efficacy of a single infusion of FDI 1,000 mg versus as much as 5 doses of iron sucrose (IS) 200 mg (advisable cumulative dose, 1,000 mg) over eight weeks in sufferers with NDD-CKD and iron deficiency anemia. Of 1,525 sufferers included in the security evaluation, 244 (16%) had a historical past of coronary heart failure (HF).
Overall, the price of critical or extreme hypersensitivity reactions was low and didn’t differ between remedy teams. Cardiovascular hostile occasions (AEs) have been reported for 9.4% of sufferers who had HF and 4.2% who didn’t. Time to first cardiovascular AE was longer following administration of FDI in contrast with IS (hazard ratio: 0.59 [95% CI: 0.37, 0.92]; p=0.0185), a distinction that was comparable in sufferers with or with out HF (p=0.908 for interplay).
Patients achieved a sooner hematological response (assessed by adjustments in hemoglobin and ferritin concentrations, and improve in transferrin saturation) with FDI versus IS. In conclusion, in sufferers with NDD-CKD, a single infusion of FDI was secure, nicely tolerated, and was related to fewer cardiovascular AEs and a sooner hematological response, in comparison with a number of doses of IS. These results have been comparable for sufferers with and with out HF.
Further proof for de novo variants in SYNCRIP as the trigger of a neurodevelopmental dysfunction
SYNCRIP encodes for the Synaptotagmin-binding cytoplasmic RNA-interacting protein, concerned in RNA-binding and regulation of a number of mobile pathways. It has been proposed as a candidate gene for neurodevelopmental problems (NDDs) with autism spectrum dysfunction (ASD), mental incapacity (ID), and epilepsy. We ascertained genetic, scientific, and neuroradiological information of three further people with novel de novo SYNCRIP variants.
All people had ID. Autistic options have been noticed in two. One particular person confirmed myoclonic-atonic epilepsy. Neuroradiological options comprised periventricular nodular heterotopia and widening of subarachnoid areas. Two frameshift variants in the extra severely affected people, seemingly end in haploinsufficiency.
The third missense variant lies in the conserved RRM 2 area seemingly affecting RNA-binding. Our findings assist the significance of RRM domains for SYNCRIP performance and counsel genotype-phenotype correlations. Our research supplies additional proof for an SYNCRIP-related NDD characterised by ID and ASD sporadically accompanied by malformations of cortical growth and myoclonic-atonic epilepsy.
Check This One: Rat Tumor Necrosis Factor (TNF) ELISA Kit is an ELISA Kit for the in vitro quantitative measurement of Rat Tumor Necrosis Factor (TNF) concentrations in serum, plasma, tissue homogenates, cell lysates, cell culture supernatants and other biological fluids. Get More Information: abx050220
Neurodegenerative Disease Risk in Carriers of Autosomal Recessive Disease
Genetics has pushed important discoveries in the area of neurodegenerative illnesses (NDDs). An rising theme in neurodegeneration warrants an pressing and complete replace: that provider standing of early-onset autosomal recessive (AR) illness, sometimes thought-about benign, is related to an elevated threat of a spectrum of late-onset NDDs.
Glucosylceramidase beta (GBA1) gene mutations, liable for the AR lysosomal storage dysfunction Gaucher illness, are a outstanding instance of this precept, having been recognized as an necessary genetic threat issue for Parkinson illness. Genetic analyses have revealed additional examples, notably GRN, TREM2, EIF2AK3, and a number of different LSD and mitochondria perform genes.
Recombinant Human DcR2 Protein |
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| RP00992 | Abclonal | 10 μg | 186 EUR |
Human DCR2/TNFRSF10D PicoKine ELISA Kit |
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| EK2067 | BosterBio | 96 wells | 510 EUR |
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Description: For quantitative detection of human DCR2/TNFRSF10D in cell culture supernates, serum and plasma (heparin, EDTA, citrate). |
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anti-DcR2 |
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| YF-PA25185 | Abfrontier | 50 ul | 400.8 EUR |
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Description: Mouse polyclonal to DcR2 |
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DcR3 Antibody |
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| 24071-100ul | SAB | 100ul | 468 EUR |
DcR1 Antibody |
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| 24079-100ul | SAB | 100ul | 468 EUR |
DcR1 Antibody |
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| 24113-100ul | SAB | 100ul | 468 EUR |
DcR3 Antibody |
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| 2140-002mg | ProSci | 0.02 mg | 206.18 EUR |
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Description: DcR3 Antibody: Apoptosis is induced by certain cytokines including TNF and Fas ligand in the TNF family through their death domain containing receptors. Several novel members in the TNFR family including DR3, DR4, DR5, and DR6 were recently discovered and function as cell death receptors. Two decoy receptors, DcR1 and DcR2, were recently identified to compete with DR4 and DR5 for their ligand TRAIL binding. A novel decoy receptor was more recently discovered and designated DcR3 and TR6, respectively,. Unlike DcR1 and DcR2, DcR3 is a soluble rather than a membrane associated molecule. DcR3 binds to FasL and LIGHT and inhibits FasL and LIGHT induced apoptosis. DcR3 transcript is expressed in a number of lung and colon carcinomas and in some normal tissues. |
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DcR3 Antibody |
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| 2140-01mg | ProSci | 0.1 mg | 523.7 EUR |
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Description: DcR3 Antibody: Apoptosis is induced by certain cytokines including TNF and Fas ligand in the TNF family through their death domain containing receptors. Several novel members in the TNFR family including DR3, DR4, DR5, and DR6 were recently discovered and function as cell death receptors. Two decoy receptors, DcR1 and DcR2, were recently identified to compete with DR4 and DR5 for their ligand TRAIL binding. A novel decoy receptor was more recently discovered and designated DcR3 and TR6, respectively,. Unlike DcR1 and DcR2, DcR3 is a soluble rather than a membrane associated molecule. DcR3 binds to FasL and LIGHT and inhibits FasL and LIGHT induced apoptosis. DcR3 transcript is expressed in a number of lung and colon carcinomas and in some normal tissues. |
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DcR1 Antibody |
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| 2179-002mg | ProSci | 0.02 mg | 206.18 EUR |
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Description: DcR1 Antibody: Apoptosis is induced by certain cytokines including TNF and Fas ligand in the TNF family through their death domain containing receptors. TRAIL/Apo2L is a new member of the TNF family and induces apoptosis of a variety of tumor cell lines. DR4 and DR5 are the recently identified functional receptors for TRAIL. Two decoy receptors for TRAIL have been identified and designated DcR1/TRID/TRAIL-R3/LIT and DcR2/TRAIL-R4/TRUNDD. DcR1 has extracellular TRAIL-binding domain but lacks intracellular signaling domain. It is a glycophospholipid-anchored cell surface protein. DcR1 transcripts were expressed in many normal human tissues but not in most cancer cell lines. Overexpression of DcR1 did not induce apoptosis, but attenuated TRAIL-induced apoptosis. |
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DcR1 Antibody |
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| 2179-01mg | ProSci | 0.1 mg | 523.7 EUR |
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Description: DcR1 Antibody: Apoptosis is induced by certain cytokines including TNF and Fas ligand in the TNF family through their death domain containing receptors. TRAIL/Apo2L is a new member of the TNF family and induces apoptosis of a variety of tumor cell lines. DR4 and DR5 are the recently identified functional receptors for TRAIL. Two decoy receptors for TRAIL have been identified and designated DcR1/TRID/TRAIL-R3/LIT and DcR2/TRAIL-R4/TRUNDD. DcR1 has extracellular TRAIL-binding domain but lacks intracellular signaling domain. It is a glycophospholipid-anchored cell surface protein. DcR1 transcripts were expressed in many normal human tissues but not in most cancer cell lines. Overexpression of DcR1 did not induce apoptosis, but attenuated TRAIL-induced apoptosis. |
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DcR1 Antibody |
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| 2299-002mg | ProSci | 0.02 mg | 206.18 EUR |
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Description: DcR1 Antibody: Apoptosis is induced by certain cytokines including TNF and Fas ligand in the TNF family through their death domain containing receptors. TRAIL/Apo2L is a new member of the TNF family and induces apoptosis of a variety of tumor cell lines. DR4 and DR5 are the recently identified functional receptors for TRAIL. Two decoy receptors for TRAIL have been identified and designated DcR1/TRID/TRAIL-R3/LIT and DcR2/TRAIL-R4/TRUNDD. DcR1 has extracellular TRAIL-binding domain but lacks intracellular signaling domain. It is a glycophospholipid-anchored cell surface protein. DcR1 transcripts are expressed in many normal human tissues but not in most cancer cell lines. Overexpression of DcR1 did not induce apoptosis, but attenuated TRAIL-induced apoptosis. |
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DcR1 Antibody |
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| 2299-01mg | ProSci | 0.1 mg | 523.7 EUR |
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Description: DcR1 Antibody: Apoptosis is induced by certain cytokines including TNF and Fas ligand in the TNF family through their death domain containing receptors. TRAIL/Apo2L is a new member of the TNF family and induces apoptosis of a variety of tumor cell lines. DR4 and DR5 are the recently identified functional receptors for TRAIL. Two decoy receptors for TRAIL have been identified and designated DcR1/TRID/TRAIL-R3/LIT and DcR2/TRAIL-R4/TRUNDD. DcR1 has extracellular TRAIL-binding domain but lacks intracellular signaling domain. It is a glycophospholipid-anchored cell surface protein. DcR1 transcripts are expressed in many normal human tissues but not in most cancer cell lines. Overexpression of DcR1 did not induce apoptosis, but attenuated TRAIL-induced apoptosis. |
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Dcr-1 Antibody |
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| abx031117-400ul | Abbexa | 400 ul | 627.6 EUR |
Dcr-1 Antibody |
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| abx031117-80l | Abbexa | 80 µl | 343.2 EUR |
Human DcR1 Antibody |
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| 33476-05111 | AssayPro | 150 ug | 313.2 EUR |
DcR3 Antibody / TNFRSF6B |
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| F54535-0.08ML | NSJ Bioreagents | 0.08 ml | 140.25 EUR |
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Description: This gene belongs to the tumor necrosis factor receptor superfamily. The encoded protein is postulated to play a regulatory role in suppressing FasL- and LIGHT-mediated cell death. It acts as a decoy receptor that competes with death receptors for ligand binding. Overexpression of this gene has been noted in gastrointestinal tract tumors, and it is located in a gene-rich cluster on chromosome 20, with other potentially tumor-related genes. Two transcript variants encoding the same isoform, but differing in the 5' UTR, have been observed for this gene. |
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DcR3 Antibody / TNFRSF6B |
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| F54535-0.4ML | NSJ Bioreagents | 0.4 ml | 322.15 EUR |
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Description: This gene belongs to the tumor necrosis factor receptor superfamily. The encoded protein is postulated to play a regulatory role in suppressing FasL- and LIGHT-mediated cell death. It acts as a decoy receptor that competes with death receptors for ligand binding. Overexpression of this gene has been noted in gastrointestinal tract tumors, and it is located in a gene-rich cluster on chromosome 20, with other potentially tumor-related genes. Two transcript variants encoding the same isoform, but differing in the 5' UTR, have been observed for this gene. |
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Polyclonal DcR3 Antibody |
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| APR06250G | Leading Biology | 0.1 mg | 790.8 EUR |
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Description: A polyclonal antibody raised in Rabbit that recognizes and binds to Human DcR3 . This antibody is tested and proven to work in the following applications: |
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Polyclonal DcR1 Antibody |
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| APR06257G | Leading Biology | 0.1 mg | 790.8 EUR |
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Description: A polyclonal antibody raised in Rabbit that recognizes and binds to Human DcR1 . This antibody is tested and proven to work in the following applications: |
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Polyclonal DcR1 Antibody |
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| APR06270G | Leading Biology | 0.1 mg | 790.8 EUR |
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Description: A polyclonal antibody raised in Rabbit that recognizes and binds to Human DcR1 . This antibody is tested and proven to work in the following applications: |
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Human Decoy Receptor 3 (DcR3) Antibody |
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| 32129-05111 | AssayPro | 150 ug | 313.2 EUR |
Human DcR1 Antibody (Biotin Conjugate) |
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| 33476-05121 | AssayPro | 150 ug | 442.8 EUR |
DcR1 Polyclonal Antibody |
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| 41854-100ul | SAB | 100ul | 302.4 EUR |
DcR1 Polyclonal Antibody |
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| 41854-50ul | SAB | 50ul | 224.4 EUR |
DcR3 Polyclonal Antibody |
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| ABP51153-003ml | Abbkine | 0.03ml | 189.6 EUR |
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Description: A polyclonal antibody for detection of DcR3 from Human. This DcR3 antibody is for WB, IHC-P, IF, ELISA. It is affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogenand is unconjugated. The antibody is produced in rabbit by using as an immunogen synthesized peptide derived from the C-terminal region of human DcR3 at AA range: 220-300 |
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DcR3 Polyclonal Antibody |
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| ABP51153-01ml | Abbkine | 0.1ml | 346.8 EUR |
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Description: A polyclonal antibody for detection of DcR3 from Human. This DcR3 antibody is for WB, IHC-P, IF, ELISA. It is affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogenand is unconjugated. The antibody is produced in rabbit by using as an immunogen synthesized peptide derived from the C-terminal region of human DcR3 at AA range: 220-300 |
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DcR3 Polyclonal Antibody |
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| ABP51153-02ml | Abbkine | 0.2ml | 496.8 EUR |
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Description: A polyclonal antibody for detection of DcR3 from Human. This DcR3 antibody is for WB, IHC-P, IF, ELISA. It is affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogenand is unconjugated. The antibody is produced in rabbit by using as an immunogen synthesized peptide derived from the C-terminal region of human DcR3 at AA range: 220-300 |
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DcR1 Polyclonal Antibody |
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| ABP53214-003ml | Abbkine | 0.03ml | 189.6 EUR |
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Description: A polyclonal antibody for detection of DcR1 from Human. This DcR1 antibody is for WB, ELISA. It is affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogenand is unconjugated. The antibody is produced in rabbit by using as an immunogen synthesized peptide derived from the Internal region of human DcR1 |
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DcR1 Polyclonal Antibody |
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| ABP53214-01ml | Abbkine | 0.1ml | 346.8 EUR |
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Description: A polyclonal antibody for detection of DcR1 from Human. This DcR1 antibody is for WB, ELISA. It is affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogenand is unconjugated. The antibody is produced in rabbit by using as an immunogen synthesized peptide derived from the Internal region of human DcR1 |
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DcR1 Polyclonal Antibody |
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| ABP53214-02ml | Abbkine | 0.2ml | 496.8 EUR |
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Description: A polyclonal antibody for detection of DcR1 from Human. This DcR1 antibody is for WB, ELISA. It is affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogenand is unconjugated. The antibody is produced in rabbit by using as an immunogen synthesized peptide derived from the Internal region of human DcR1 |
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DcR1 Polyclonal Antibody |
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| ES4213-100ul | ELK Biotech | 100ul | 334.8 EUR |
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Description: A Rabbit Polyclonal antibody against DcR1 from Human. This antibody is tested and validated for WB, ELISA, WB, ELISA |
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DcR1 Polyclonal Antibody |
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| ES4213-50ul | ELK Biotech | 50ul | 248.4 EUR |
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Description: A Rabbit Polyclonal antibody against DcR1 from Human. This antibody is tested and validated for WB, ELISA, WB, ELISA |
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DcR3 Polyclonal Antibody |
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| ES2152-100ul | ELK Biotech | 100ul | 334.8 EUR |
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Description: A Rabbit Polyclonal antibody against DcR3 from Human. This antibody is tested and validated for WB, ELISA, IHC, IF, WB, ELISA |
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DcR3 Polyclonal Antibody |
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| ES2152-50ul | ELK Biotech | 50ul | 248.4 EUR |
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Description: A Rabbit Polyclonal antibody against DcR3 from Human. This antibody is tested and validated for WB, ELISA, IHC, IF, WB, ELISA |
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Human Decoy Receptor 3 (DcR3) Antibody (Biotin Conjugate) |
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| 32129-05121 | AssayPro | 150 ug | 442.8 EUR |
DcR1 Polyclonal Conjugated Antibody |
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| C41854 | SAB | 100ul | 476.4 EUR |
Human DcR1 AssayLite Antibody (RPE Conjugate) |
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| 33476-05151 | AssayPro | 150 ug | 513.6 EUR |
Human DcR1 AssayLite Antibody (APC Conjugate) |
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| 33476-05161 | AssayPro | 150 ug | 513.6 EUR |
Human DcR1 AssayLite Antibody (FITC Conjugate) |
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| 33476-05141 | AssayPro | 150 ug | 513.6 EUR |
Human DcR1 AssayLite Antibody (PerCP Conjugate) |
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| 33476-05171 | AssayPro | 150 ug | 565.2 EUR |
Human Decoy Receptor 3 (DcR3) AssayLite Antibody (RPE Conjugate) |
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| 32129-05151 | AssayPro | 150 ug | 513.6 EUR |
Human Decoy Receptor 3 (DcR3) AssayLite Antibody (APC Conjugate) |
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| 32129-05161 | AssayPro | 150 ug | 513.6 EUR |
Human Decoy Receptor 3 (DcR3) AssayLite Antibody (FITC Conjugate) |
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| 32129-05141 | AssayPro | 150 ug | 513.6 EUR |
Human Decoy Receptor 3 (DcR3) AssayLite Antibody (PerCP Conjugate) |
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| 32129-05171 | AssayPro | 150 ug | 565.2 EUR |
Rabbit Anti-Drosophila Cryptochrome (dCRY) antiserum # 1 |
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| CRYD13-S | Alpha Diagnostics | 100 ul | 548.4 EUR |
Rabbit Anti-Drosophila Cryptochrome (dCRY) IgG # 1, aff pure |
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| CRYD13-A | Alpha Diagnostics | 100 ug | 578.4 EUR |
Human Dcr1 homolog Drosophila DCR1(DICER1) ELISA Kit |
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| YLA3763HU-48T | Shanghai YL Biotech | 48T | 435 EUR |
Human Dcr1 homolog Drosophila DCR1(DICER1) ELISA Kit |
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| YLA3763HU-96T | Shanghai YL Biotech | 96T | 562.5 EUR |
Anti-Anti-SEPT5 Antibody antibody |
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| STJ114819 | St John's Laboratory | 100 µl | 332.4 EUR |
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Description: This gene is a member of the septin gene family of nucleotide binding proteins, originally described in yeast as cell division cycle regulatory proteins. Septins are highly conserved in yeast, Drosophila, and mouse and appear to regulate cytoskeletal organization. Disruption of septin function disturbs cytokinesis and results in large multinucleate or polyploid cells. This gene is mapped to 22q11, the region frequently deleted in DiGeorge and velocardiofacial syndromes. A translocation involving the MLL gene and this gene has also been reported in patients with acute myeloid leukemia. Alternative splicing results in multiple transcript variants. The presence of a non-consensus polyA signal (AACAAT) in this gene also results in read-through transcription into the downstream neighboring gene (GP1BB; platelet glycoprotein Ib), whereby larger, non-coding transcripts are produced. |
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Anti-Anti-SEPT2 Antibody antibody |
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| STJ28365 | St John's Laboratory | 100 µl | 332.4 EUR |
Anti-Anti-SEPT7 Antibody antibody |
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| STJ28963 | St John's Laboratory | 100 µl | 332.4 EUR |
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Description: This gene encodes a protein that is highly similar to the CDC10 protein of Saccharomyces cerevisiae. The protein also shares similarity with Diff 6 of Drosophila and with H5 of mouse. Each of these similar proteins, including the yeast CDC10, contains a GTP-binding motif. The yeast CDC10 protein is a structural component of the 10 nm filament which lies inside the cytoplasmic membrane and is essential for cytokinesis. This human protein functions in gliomagenesis and in the suppression of glioma cell growth, and it is required for the association of centromere-associated protein E with the kinetochore. Alternative splicing results in multiple transcript variants. Several related pseudogenes have been identified on chromosomes 5, 7, 9, 10, 11, 14, 17 and 19. |
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Anti-Anti-SEPT3 Antibody antibody |
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| STJ118990 | St John's Laboratory | 100 µl | 332.4 EUR |
Anti-Anti-SEPT1 antibody antibody |
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| STJ119580 | St John's Laboratory | 100 µl | 332.4 EUR |
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Description: This gene is a member of the septin family of GTPases. Members of this family are required for cytokinesis and the maintenance of cellular morphology. This gene encodes a protein that can form homo- and heterooligomeric filaments, and may contribute to the formation of neurofibrillary tangles in Alzheimer's disease. Alternatively spliced transcript variants have been found but the full-length nature of these variants has not been determined. [provided by RefSeq, Dec 2012] |
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Anti-Anti-SEPT6 antibody antibody |
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| STJ11100949 | St John's Laboratory | 100 µl | 332.4 EUR |
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Description: This gene is a member of the septin family of GTPases. Members of this family are required for cytokinesis. One version of pediatric acute myeloid leukemia is the result of a reciprocal translocation between chromosomes 11 and X, with the breakpoint associated with the genes encoding the mixed-lineage leukemia and septin 2 proteins. This gene encodes four transcript variants encoding three distinct isoforms. An additional transcript variant has been identified, but its biological validity has not been determined. |
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Anti-Anti-SEPT9 Antibody antibody |
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| STJ111369 | St John's Laboratory | 100 µl | 332.4 EUR |
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Description: This gene is a member of the septin family involved in cytokinesis and cell cycle control. This gene is a candidate for the ovarian tumor suppressor gene. Mutations in this gene cause hereditary neuralgic amyotrophy, also known as neuritis with brachial predilection. A chromosomal translocation involving this gene on chromosome 17 and the MLL gene on chromosome 11 results in acute myelomonocytic leukemia. Multiple alternatively spliced transcript variants encoding different isoforms have been described. |
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Anti-Anti-SEPT4 Antibody antibody |
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| STJ112276 | St John's Laboratory | 100 µl | 332.4 EUR |
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Description: This gene is a member of the septin family of nucleotide binding proteins, originally described in yeast as cell division cycle regulatory proteins. Septins are highly conserved in yeast, Drosophila, and mouse, and appear to regulate cytoskeletal organization. Disruption of septin function disturbs cytokinesis and results in large multinucleate or polyploid cells. This gene is highly expressed in brain and heart. Alternatively spliced transcript variants encoding different isoforms have been described for this gene. One of the isoforms (known as ARTS) is distinct; it is localized to the mitochondria, and has a role in apoptosis and cancer. |
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Anti-Anti-SEPT7 Antibody antibody |
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| STJ116214 | St John's Laboratory | 100 µl | 332.4 EUR |
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Description: This gene encodes a protein that is highly similar to the CDC10 protein of Saccharomyces cerevisiae. The protein also shares similarity with Diff 6 of Drosophila and with H5 of mouse. Each of these similar proteins, including the yeast CDC10, contains a GTP-binding motif. The yeast CDC10 protein is a structural component of the 10 nm filament which lies inside the cytoplasmic membrane and is essential for cytokinesis. This human protein functions in gliomagenesis and in the suppression of glioma cell growth, and it is required for the association of centromere-associated protein E with the kinetochore. Alternative splicing results in multiple transcript variants. Several related pseudogenes have been identified on chromosomes 5, 7, 9, 10, 11, 14, 17 and 19. |
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Anti-Anti-SEPT8 Antibody antibody |
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| STJ117206 | St John's Laboratory | 100 µl | 332.4 EUR |
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Description: This gene is a member of the septin family of nucleotide binding proteins, originally described in yeast as cell division cycle regulatory proteins. Septins are highly conserved in yeast, Drosophila, and mouse, and appear to regulate cytoskeletal organization. Disruption of septin function disturbs cytokinesis and results in large multinucleate or polyploid cells. Multiple alternatively spliced transcript variants encoding different isoforms have been found for this gene. |
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Anti-Anti-SEPT2 Antibody antibody |
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| STJ25475 | St John's Laboratory | 100 µl | 332.4 EUR |
Anti-Anti-SEPT5 Antibody antibody |
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| STJ25477 | St John's Laboratory | 100 µl | 332.4 EUR |
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Description: This gene is a member of the septin gene family of nucleotide binding proteins, originally described in yeast as cell division cycle regulatory proteins. Septins are highly conserved in yeast, Drosophila, and mouse and appear to regulate cytoskeletal organization. Disruption of septin function disturbs cytokinesis and results in large multinucleate or polyploid cells. This gene is mapped to 22q11, the region frequently deleted in DiGeorge and velocardiofacial syndromes. A translocation involving the MLL gene and this gene has also been reported in patients with acute myeloid leukemia. Alternative splicing results in multiple transcript variants. The presence of a non-consensus polyA signal (AACAAT) in this gene also results in read-through transcription into the downstream neighboring gene (GP1BB; platelet glycoprotein Ib), whereby larger, non-coding transcripts are produced. |
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Anti-Anti-SEPT8 Antibody antibody |
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| STJ25479 | St John's Laboratory | 100 µl | 332.4 EUR |
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Description: This gene is a member of the septin family of nucleotide binding proteins, originally described in yeast as cell division cycle regulatory proteins. Septins are highly conserved in yeast, Drosophila, and mouse, and appear to regulate cytoskeletal organization. Disruption of septin function disturbs cytokinesis and results in large multinucleate or polyploid cells. Multiple alternatively spliced transcript variants encoding different isoforms have been found for this gene. |
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Anti-Anti-MARCH9 Antibody antibody |
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| STJ112609 | St John's Laboratory | 100 µl | 332.4 EUR |
Anti-Anti-SEPT11 Antibody antibody |
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| STJ113941 | St John's Laboratory | 100 µl | 332.4 EUR |
Anti-Anti-SEPT11 Antibody antibody |
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| STJ114081 | St John's Laboratory | 100 µl | 332.4 EUR |
Anti-Anti-MARCH8 Antibody antibody |
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| STJ114828 | St John's Laboratory | 100 µl | 332.4 EUR |
Anti-Anti-SEPT12 Antibody antibody |
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| STJ117759 | St John's Laboratory | 100 µl | 332.4 EUR |
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Description: This gene encodes a guanine-nucleotide binding protein and member of the septin family of cytoskeletal GTPases. Septins play important roles in cytokinesis, exocytosis, embryonic development, and membrane dynamics. Multiple transcript variants encoding different isoforms have been found for this gene. |
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Anti-Anti-MARCH6 Antibody antibody |
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| STJ118549 | St John's Laboratory | 100 µl | 332.4 EUR |
Anti-Anti-MARCH6 Antibody antibody |
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| STJ118550 | St John's Laboratory | 100 µl | 332.4 EUR |
Anti-Anti-MARCH7 Antibody antibody |
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| STJ118752 | St John's Laboratory | 100 µl | 332.4 EUR |
Anti-Anti-SEPT11 Antibody antibody |
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| STJ111530 | St John's Laboratory | 100 µl | 332.4 EUR |
DcR3 Peptide |
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| 2140P | ProSci | 0.05 mg | 197.7 EUR |
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Description: (NT) DcR3 peptide |
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DcR1 Peptide |
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| 2179P | ProSci | 0.05 mg | 197.7 EUR |
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Description: (ED) DcR1 peptide |
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DcR1 Peptide |
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| 2299P | ProSci | 0.05 mg | 197.7 EUR |
|
Description: (ED2) DcR1 peptide |
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Nori® Human DcR3 ELISA Kit |
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| GR106267 | Genorise Scientific | 96-well | 461 EUR |
Nori® Human DcR3 ELISA Kit (2 plates) |
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| GR106267-2 | Genorise Scientific | 2 x 96-well | 832 EUR |
Anti-Anti-DDB1 Antibody |
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| A00333 | BosterBio | 100uL | 546 EUR |
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Description: Rabbit Polyclonal DDB1 Antibody. Validated in IP and tested in Human, Mouse. |
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DcR3 Recombinant Protein |
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| 90-454 | ProSci | 100 ug | 682.8 EUR |
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Description: Decoy receptor 3 (DcR3; TNFRSF6B; M68) is a member of the TNF receptor superfamily. DcR3 shares sequence identity with OPG (31%), TNF-RII (29%) and Fas (17%) and is expressed in a variety of different tissues and at high levels in many malignant tumors. Ligands of DcR3 include Fas ligand, homologous to lymphotoxin showing inducible expression and competing with HSV glycoprotein D for herpes virus entry mediator (a receptor expressed by T lymphocytes), TNF-like molecule 1A and heparan sulfate proteoglycans. DcR3 modulates the function of T cells, dendritic cells and macrophages. DcR3/Fc fusion proteins can bind to human and mouse B cells and suppress the activation of B cells. |
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ELISA kit for Human DCR3/TNFRSF6B |
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| EK5315 | SAB | 96 tests | 663.6 EUR |
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Description: Enzyme-linked immunosorbent assay kit for quantification of Human DCR3/TNFRSF6B in samples from serum, plasma, tissue homogenates and other biological fluids. |
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Human Anti-Anti-Sperm Antibody Antibody (Anti-AsAb) ELISA Kit |
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| AEA465Hu-10x96wellstestplate | Cloud-Clone | 10x96-wells test plate | 6777.36 EUR |
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Description: This is Competitive Enzyme-linked immunosorbent assay for Antibody Detection.detection of Human Anti-Anti-Sperm Antibody Antibody (Anti-AsAb) in serum, plasma and other biological fluids. |
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Human Anti-Anti-Sperm Antibody Antibody (Anti-AsAb) ELISA Kit |
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| AEA465Hu-1x48wellstestplate | Cloud-Clone | 1x48-wells test plate | 663.31 EUR |
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Description: This is Competitive Enzyme-linked immunosorbent assay for Antibody Detection.detection of Human Anti-Anti-Sperm Antibody Antibody (Anti-AsAb) in serum, plasma and other biological fluids. |
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Human Anti-Anti-Sperm Antibody Antibody (Anti-AsAb) ELISA Kit |
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| AEA465Hu-1x96wellstestplate | Cloud-Clone | 1x96-wells test plate | 896.16 EUR |
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Description: This is Competitive Enzyme-linked immunosorbent assay for Antibody Detection.detection of Human Anti-Anti-Sperm Antibody Antibody (Anti-AsAb) in serum, plasma and other biological fluids. |
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Human Anti-Anti-Sperm Antibody Antibody (Anti-AsAb) ELISA Kit |
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| AEA465Hu-5x96wellstestplate | Cloud-Clone | 5x96-wells test plate | 3672.72 EUR |
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Description: This is Competitive Enzyme-linked immunosorbent assay for Antibody Detection.detection of Human Anti-Anti-Sperm Antibody Antibody (Anti-AsAb) in serum, plasma and other biological fluids. |
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Human Anti-Anti-Sperm Antibody Antibody (Anti-AsAb) ELISA Kit |
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| 4-AEA465Hu | Cloud-Clone |
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Description: Enzyme-linked immunosorbent assay based on the Competitive Inhibition method for detection of Human Anti-Anti-Sperm Antibody Antibody (Anti-AsAb) in samples from serum, plasma and other biological fluids with no significant corss-reactivity with analogues from other species. |
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Human decoy receptor 3,DcR3 ELISA Kit |
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| YLA4114HU-48T | Shanghai YL Biotech | 48T | 435 EUR |
Human decoy receptor 3,DcR3 ELISA Kit |
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| YLA4114HU-96T | Shanghai YL Biotech | 96T | 562.5 EUR |
Anti-BOD1 antibody |
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| STJ72155 | St John's Laboratory | 100 µg | 430.8 EUR |
Recombinant DcR3 Protein (Val 30-His 300) [Fc] |
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| VAng-1447Lsx-1mg | Creative Biolabs | 1 mg | 8308.8 EUR |
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Description: Human DcR3 (TNFRSF6B), Fc tag, is expressed in HEK 293 cells. (Uniprot ID: AAH17065) |
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Recombinant DcR3 Protein (Val 30-His 300) [Fc] |
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| VAng-1447Lsx-50g | Creative Biolabs | 50 µg | 1099.2 EUR |
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Description: Human DcR3 (TNFRSF6B), Fc tag, is expressed in HEK 293 cells. (Uniprot ID: AAH17065) |
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Anti-BOD1L antibody |
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| STJ73530 | St John's Laboratory | 100 µg | 312 EUR |
ELISA kit for Human Anti-AsAb (Anti-Anti-Sperm Antibody Antibody) |
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| ELK8071 | ELK Biotech | 1 plate of 96 wells | 518.4 EUR |
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Description: A competitive Inhibition ELISA kit for detection of Anti-Anti-Sperm Antibody Antibody from Human in samples from blood, serum, plasma, cell culture fluid and other biological fluids. |
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anti- Antibody^Polyclonal antibody control antibody |
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| LSMab09882 | Lifescience Market | 100 ug | 525.6 EUR |
Human DCR3/TNFRSF6B PicoKine ELISA Kit |
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| EK0748 | BosterBio | 96 wells | 510 EUR |
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Description: For quantitative detection of human DCR3 in cell culture supernates, cell lysates, serum and plasma (heparin, EDTA). |
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Anti-7B2 antibody |
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| STJ191062 | St John's Laboratory | 200 µl | 236.4 EUR |
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Description: Unconjugated Rabbit polyclonal to 7B2 |
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Anti-4.1G Antibody |
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| A03718 | BosterBio | 100ul | 476.4 EUR |
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Description: Rabbit Polyclonal Antibody for 4.1G Antibody (EPB41L2) detection.tested for WB in Human. |
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Anti-4.1G antibody |
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| STJ91381 | St John's Laboratory | 200 µl | 236.4 EUR |
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Description: Rabbit polyclonal to 4.1G. |
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Anti-4.1R antibody |
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| STJ91382 | St John's Laboratory | 200 µl | 236.4 EUR |
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Description: Rabbit polyclonal to 4.1R. |
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Anti-BOC Antibody |
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| PA1904 | BosterBio | 100ug/vial | 352.8 EUR |
Anti-BOK antibody |
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| STJ190601 | St John's Laboratory | 200 µl | 236.4 EUR |
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Description: Unconjugated Rabbit polyclonal to BOK |
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Anti-BOC antibody |
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| STJ71520 | St John's Laboratory | 100 µg | 430.8 EUR |
Anti-BOK antibody |
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| STJ72368 | St John's Laboratory | 100 µg | 430.8 EUR |
Anti-BOC antibody |
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| STJ192335 | St John's Laboratory | 200 µl | 236.4 EUR |
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Description: Unconjugated Rabbit polyclonal to BOC |
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Anti-BOC antibody |
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| STJ29254 | St John's Laboratory | 100 µl | 332.4 EUR |
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Description: The protein encoded by this gene is a member of the immunoglobulin/fibronectin type III repeat family. It is a component of a cell-surface receptor complex that mediates cell-cell interactions between muscle precursor cells, and promotes myogenic differentiation. Alternative splicing results in multiple transcript variants encoding different isoforms. |
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Anti-BoV antibody |
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| STJ400075 | St John's Laboratory | 1 mg | 535.2 EUR |
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Description: Human bocavirus (also termed HBoV) is a small non-enveloped virus with a single- stranded DNA genome. It is a member of the Parvoviridae family. HBoV has been detected worldwide in 2–20 % of all upper and lower respiratory tract infections, and has also been linked to gastroenteritis. |
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Anti-BOK antibody |
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| STJ118794 | St John's Laboratory | 100 µl | 332.4 EUR |
Anti-BOC antibody |
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| STJ115407 | St John's Laboratory | 100 µl | 332.4 EUR |
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Description: The protein encoded by this gene is a member of the immunoglobulin/fibronectin type III repeat family. It is a component of a cell-surface receptor complex that mediates cell-cell interactions between muscle precursor cells, and promotes myogenic differentiation. Alternative splicing results in multiple transcript variants encoding different isoforms. |
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Anti-2B1F antibody |
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| STJ190870 | St John's Laboratory | 200 µl | 236.4 EUR |
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Description: Unconjugated Rabbit polyclonal to 2B1F |
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Anti-53BP1 antibody |
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| STJ91389 | St John's Laboratory | 200 µl | 236.4 EUR |
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Description: Rabbit polyclonal to 53BP1. |
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Anti-53BP1 antibody |
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| STJ91390 | St John's Laboratory | 200 µl | 236.4 EUR |
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Description: Rabbit polyclonal to 53BP1. |
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Anti-53BP1 antibody |
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| STJ91391 | St John's Laboratory | 200 µl | 236.4 EUR |
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Description: Rabbit polyclonal to 53BP1. |
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Anti-BOB1 antibody |
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| STJ180315 | St John's Laboratory | 0.1 ml | 254.4 EUR |
Anti-BORA antibody |
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| STJ190128 | St John's Laboratory | 200 µl | 236.4 EUR |
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Description: Unconjugated Rabbit polyclonal to BORA |
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Anti-BOP1 antibody |
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| STJ191341 | St John's Laboratory | 200 µl | 236.4 EUR |
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Description: Unconjugated Rabbit polyclonal to BOP1 |
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Anti-BOCT antibody |
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| STJ96427 | St John's Laboratory | 200 µl | 236.4 EUR |
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Description: Rabbit polyclonal to BOCT. |
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Anti-BORA antibody |
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| STJ115786 | St John's Laboratory | 100 µl | 332.4 EUR |
Anti-B23 antibody |
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| PAab00759 | Lifescience Market | 100 ug | 494.4 EUR |
Anti-B19 Antibody |
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| STJ501374 | St John's Laboratory | 100 µg | 571.2 EUR |
Anti-B23 antibody |
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| STJ97858 | St John's Laboratory | 100 µl | 280.8 EUR |
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Description: Mouse monoclonal to B23. |
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Anti-B23 antibody |
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| STJ98470 | St John's Laboratory | 100 µl | 280.8 EUR |
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Description: Mouse monoclonal to B23. |
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Anti-B23 antibody |
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| STJ91794 | St John's Laboratory | 200 µl | 236.4 EUR |
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Description: Rabbit polyclonal to B23. |
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anti- TH antibody |
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| FNab08655 | FN Test | 100µg | 702 EUR |
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Description: Antibody raised against TH |
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anti- XK antibody |
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| FNab09543 | FN Test | 100µg | 658.5 EUR |
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Description: Antibody raised against XK |
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anti- PR antibody |
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| FNab09774 | FN Test | 100µg | 658.5 EUR |
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Description: Antibody raised against PR |
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anti- T3 antibody |
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| FNab09808 | FN Test | 100µg | 658.5 EUR |
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Description: Antibody raised against T3 |
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anti- T4 antibody |
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| FNab09809 | FN Test | 100µg | 658.5 EUR |
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Description: Antibody raised against T4 |
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anti- TH antibody |
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| FNab09870 | FN Test | 100µg | 658.5 EUR |
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Description: Antibody raised against TH |
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anti- C9 antibody |
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| FNab10107 | FN Test | 100µg | 658.5 EUR |
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Description: Antibody raised against C9 |
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anti- C9 antibody |
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| FNab10108 | FN Test | 100µg | 658.5 EUR |
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Description: Antibody raised against C9 |
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anti- Rb antibody |
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| FNab07140 | FN Test | 100µg | 606.3 EUR |
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Description: Antibody raised against Rb |
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anti- ER antibody |
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| FNab02822 | FN Test | 100µg | 606.3 EUR |
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Description: Antibody raised against ER |
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anti- F2 antibody |
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| FNab02920 | FN Test | 100µg | 606.3 EUR |
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Description: Antibody raised against F2 |
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anti- F5 antibody |
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| FNab02923 | FN Test | 100µg | 606.3 EUR |
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Description: Antibody raised against F5 |
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anti- F7 antibody |
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| FNab02924 | FN Test | 100µg | 606.3 EUR |
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Description: Antibody raised against F7 |
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anti- F9 antibody |
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| FNab02925 | FN Test | 100µg | 606.3 EUR |
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Description: Antibody raised against F9 |
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In this Review, we talk about the proof supporting the strikingly distinct allele-dependent scientific phenotypes noticed in carriers of such gene mutations and its affect on the wider area of neurodegeneration.
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