Neurotrophic

Neurotrophic

The Effect of Lactobacillus casei Consumption in Improvement of Obsessive-Compulsive Disorder: an Animal Study.

Obsessive-compulsive disorder (OCD) is an important neuropsychiatric disorder worldwide. Common treatments of OCD include serotonergic antidepressants, which can cause potentially serious side effects. We assessed the effects of Lactobacillus casei (L. casei) Shirota consumption in an animal model of OCD. OCD-like symptoms were induced in rats by the chronic injection of the D2/D3 dopamine agonist quinpirole hydrochloride. Rats were classified into five groups of 6 rats. Four groups were injected chronically with quinpirole (0.5 mg/kg, twice weekly for 5 weeks). They were fed with L. casei Shirota (109 CF/g, daily for 4 weeks) (group 1), fluoxetine (10 mg/kg, daily for 4 weeks) (group 2), combination of L. casei Shirota and fluoxetine (group 3), and normal saline (positive control group). The last group did not receive dopamine agonist and was only injected with saline (negative control group).

Expression levels of brain-derived neurotrophic factor (Bdnf), solute carrier family 6 member 4 (Slc6a4), and 5-hydroxytryptamine receptor type 2A (Htr2a) were assessed in orbitofrontal cortex tissues of all rats. Behavioral tests showed improvement of OCD signs in rats treated with L. casei Shirota, fluoxetine, and a combination of drugs. Quantitative PCR analysis showed a remarkable decrease in the expression of Bdnf and an increase in the expression of Htr2a in quinpirole-treated rats. After treatment with L. casei Shirota and fluoxetine, the expression level of Bdnf was increased remarkably, whereas Htr2a expression was decreased. The current study showed the effectiveness of L. casei Shirota in the treatment of OCD in a rat model. The beneficial effects of this probiotic are possibly exerted through the modulation of serotonin-related genes expression.


Low brain-derived neurotrophic factor protein levels and single-nucleotide polymorphism Val66Met are associated with peripheral neuropathy in type II diabetic patients.

Studies by our group demonstrated brain-derived neurotrophic factor (BDNF) levels in blood and BDNF-Val66met-SNP as potential biomarkers in chemotherapy-induced peripheral neuropathy.

Here, we evaluate symptoms of peripheral neuropathy (PN) and depression in patients with type II diabetes mellitus in search of an association with serum BDNF levels and the Val66Met-SNP.In total, 90 patients enrolled in the study; 23 (25.6%) had known PN, as determined by nerve conduction studies (NCS-PN), and 67 (74.4%) were not diagnosed with PN (U-PN). PN symptoms were assessed and graded in these groups using the total neuropathy score (TNSr) and DN4 scales. Small nerve fiber testing of sensitivity thresholds to cold, warm and hot pain signals was performed using the Q-sense device.

Depression was assessed using the PHQ9 questionnaire. BDNF protein levels and Val66Met-SNP were determined with ELISA and Sanger sequencing, respectively.NCS-PN patients showed lower serum BDNF levels alongside significantly higher TNSr, DN4 and PHQ9 scores and lower hot pain sensitivity thresholds as compared to U-PN patients. Patients with Met-BDNF-SNP showed increased TNSr scores and lower hot pain sensitivity thresholds as compared to patients with Val-BDNF-SNP.

Depression showed a weaker correlation with sensitivity thresholds to hot pain signals as compared to TNSr and DN4 scores.Diminished peripheral BDNF resources and Met-BDNF-SNP genotype are associated with augmented symptoms of PN in patients with type II diabetes mellitus. Sensitivity thresholds to hot pain signals may be less influenced by depression and possibly more accurately detect PN symptoms in diabetic patients.

Ciliary Neurotrophic Factor (CNTF) Antibody

20-abx102721
  • EUR 314.00
  • EUR 133.00
  • EUR 829.00
  • EUR 425.00
  • EUR 272.00
  • 100 ug
  • 10 ug
  • 1 mg
  • 200 ug
  • 50 ug
  • Shipped within 5-15 working days.
  • Ciliary Neurotrophic Factor (CNTF) Antibody

    20-abx102722
    • EUR 411.00
    • EUR 133.00
    • EUR 1135.00
    • EUR 551.00
    • EUR 314.00
    • 100 ug
    • 10 ug
    • 1 mg
    • 200 ug
    • 50 ug
  • Shipped within 5-7 working days.
  • Ciliary Neurotrophic Factor (CNTF) Antibody

    20-abx102723
    • EUR 425.00
    • EUR 133.00
    • EUR 1177.00
    • EUR 578.00
    • EUR 328.00
    • 100 ug
    • 10 ug
    • 1 mg
    • 200 ug
    • 50 ug
  • Shipped within 5-12 working days.
  • Ciliary Neurotrophic Factor (CNTF) Antibody

    20-abx134025
    • EUR 356.00
    • EUR 537.00
    • EUR 217.00
    • 100 ul
    • 200 ul
    • 30 ul
  • Shipped within 5-10 working days.
  • Neudesin Neurotrophic Factor (NENF) Antibody

    20-abx128254
    • EUR 425.00
    • EUR 133.00
    • EUR 1205.00
    • EUR 578.00
    • EUR 328.00
    • 100 ug
    • 10 ug
    • 1 mg
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    • 50 ug
  • Shipped within 5-7 working days.
  • Ciliary Neurotrophic Factor (CNTF) Antibody

    20-abx129965
    • EUR 453.00
    • EUR 133.00
    • EUR 1288.00
    • EUR 620.00
    • EUR 342.00
    • 100 ug
    • 10 ug
    • 1 mg
    • 200 ug
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  • Shipped within 5-7 working days.
  • Ciliary Neurotrophic Factor (CNTF) Antibody

    20-abx126869
    • EUR 411.00
    • EUR 592.00
    • 100 ul
    • 200 ul
  • Shipped within 5-10 working days.
  • Ciliary Neurotrophic Factor (CNTF) Antibody

    20-abx109649
    • EUR 411.00
    • EUR 1845.00
    • EUR 599.00
    • EUR 182.00
    • EUR 300.00
    • 100 ug
    • 1 mg
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    • 20 ug
    • 50 ug
  • Shipped within 5-10 working days.
  • Ciliary neurotrophic factor Polyclonal Antibody

    42448-100ul 100ul
    EUR 333.00

    Brain Injury Derived Neurotrophic Peptide

    5-00866 4 x 5mg EUR 0.00

    Ciliary Neurotrophic Factor (CNTF) Antibody

    abx034848-400ul 400 ul
    EUR 523.00
  • Shipped within 5-10 working days.
  • Ciliary Neurotrophic Factor (CNTF) Antibody

    abx034848-80l 80 µl
    EUR 286.00
  • Shipped within 5-10 working days.
  • Ciliary Neurotrophic Factor (CNTF) Antibody

    abx037369-100ug 100 ug
    EUR 391.00
  • Shipped within 5-10 working days.
  • Ciliary Neurotrophic Factor (CNTF) Antibody

    abx038145-100ug 100 ug
    EUR 391.00
  • Shipped within 5-10 working days.
  • Ciliary Neurotrophic Factor (CNTF) Antibody

    abx038378-100ug 100 ug
    EUR 391.00
  • Shipped within 5-10 working days.
  • Ciliary Neurotrophic Factor (CNTF) Antibody

    20-abx001565
    • EUR 411.00
    • EUR 592.00
    • EUR 182.00
    • EUR 314.00
    • 100 ul
    • 200 ul
    • 20 ul
    • 50 ul
  • Shipped within 5-10 working days.
  • Cerebral Dopamine Neurotrophic Factor Protein

    20-abx261630
    • EUR 3418.00
    • EUR 328.00
    • EUR 230.00
    • 1 mg
    • 20 ug
    • 5 ug
  • Shipped within 5-10 working days.
  • Cerebral Dopamine Neurotrophic Factor Protein

    20-abx261674
    • EUR 3418.00
    • EUR 328.00
    • EUR 230.00
    • 1 mg
    • 20 ug
    • 5 ug
  • Shipped within 5-10 working days.
  • Cerebral Dopamine Neurotrophic Factor Protein

    20-abx261675
    • EUR 3418.00
    • EUR 328.00
    • EUR 230.00
    • 1 mg
    • 20 ug
    • 5 ug
  • Shipped within 5-10 working days.
  • Ciliary Neurotrophic Factor (CNTF) Antibody

    abx431174-200ul 200 ul
    EUR 384.00
  • Shipped within 1-3 working days.
  • Brain Injury Derived Neurotrophic Peptide

    20-abx266438
    • EUR 551.00
    • EUR 926.00
    • EUR 398.00
    • 10 mg
    • 25 mg
    • 5 mg
  • Shipped within 5-10 working days.
  • Ciliary Neurotrophic Factor (CNTF) Antibody

    20-abx175868
    • EUR 1135.00
    • EUR 551.00
    • 1 mg
    • 200 ug
  • Please enquire.
  • Ciliary Neurotrophic Factor (CNTF) Antibody

    20-abx175869
    • EUR 1177.00
    • EUR 578.00
    • 1 mg
    • 200 ug
  • Please enquire.
  • Ciliary Neurotrophic Factor (CNTF) Antibody

    20-abx171748
    • EUR 704.00
    • EUR 356.00
    • 1 mg
    • 200 ug
  • Please enquire.
  • Ciliary Neurotrophic Factor (CNTF) Antibody

    20-abx171749
    • EUR 843.00
    • EUR 439.00
    • 1 mg
    • 200 ug
  • Please enquire.
  • Ciliary Neurotrophic Factor (CNTF) Antibody

    20-abx171750
    • EUR 843.00
    • EUR 439.00
    • 1 mg
    • 200 ug
  • Please enquire.
  • Ciliary Neurotrophic Factor (CNTF) Antibody

    20-abx171751
    • EUR 843.00
    • EUR 439.00
    • 1 mg
    • 200 ug
  • Please enquire.
  • Ciliary Neurotrophic Factor (CNTF) Antibody

    20-abx171752
    • EUR 913.00
    • EUR 467.00
    • 1 mg
    • 200 ug
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  • Neudesin Neurotrophic Factor (NENF) Antibody

    20-abx173748
    • EUR 857.00
    • EUR 439.00
    • 1 mg
    • 200 ug
  • Please enquire.
  • Recombinant Human Ciliary Neurotrophic Factor

    7-00229 5µg EUR 0.00

    Recombinant Human Ciliary Neurotrophic Factor

    7-00231 1mg EUR 0.00

    Recombinant Rat Ciliary Neurotrophic Factor

    7-00235 5µg EUR 0.00

    Recombinant Rat Ciliary Neurotrophic Factor

    7-00237 1mg EUR 0.00

    Activity-Dependent Neurotrophic Factor-14

    5-00580 4 x 5mg EUR 0.00

    Activity – Dependent Neurotrophic Factor, ADNF

    5-00581 4 x 5mg EUR 0.00

    Recombinant Human Ciliary Neurotrophic Factor

    7-00230 20µg EUR 0.00

    Recombinant Rat Ciliary Neurotrophic Factor

    7-00236 25µg EUR 0.00

    BDNF/Brain-derived neurotrophic factor

    E21-076 10ug
    EUR 343.00

    Brain Injury Derived Neurotrophic Peptide

    H-3914.0001 1.0mg
    EUR 151.00
    Description: Sum Formula: C62H102N18O18; CAS# [148330-12-5]

    Brain Injury Derived Neurotrophic Peptide

    H-3914.0005 5.0mg
    EUR 515.00
    Description: Sum Formula: C62H102N18O18; CAS# [148330-12-5]

    Brain Injury Derived Neurotrophic Peptide

    SP-100434-1 1 mg
    EUR 286.00

    Ciliary Neurotrophic Factor, CNTF, human

    RC218-19 5ug
    EUR 104.38
  • Product category: Proteins/Recombinant Proteins/Neurotrophins
  • Recombinant Neudesin Neurotrophic Factor (NENF)

    4-RPH544Hu01
    • EUR 501.41
    • EUR 237.00
    • EUR 1605.28
    • EUR 601.76
    • EUR 1103.52
    • EUR 398.00
    • EUR 3863.20
    • 100 ug
    • 10ug
    • 1 mg
    • 200 ug
    • 500 ug
    • 50ug
    • 5 mg
  • Uniprot ID: Q9UMX5
  • Buffer composition: PBS, pH 7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
  • Form: Freeze-dried powder
  • Predicted Molecular Mass (KD): 19.4kDa
  • Isoelectric Point: Inquire
  • Description: Recombinant Human Neudesin Neurotrophic Factor expressed in: E.coli

    Recombinant Ciliary Neurotrophic Factor (CNTF)

    4-RPA021Hu01
    • EUR 322.21
    • EUR 189.00
    • EUR 933.28
    • EUR 377.76
    • EUR 655.52
    • EUR 278.00
    • EUR 2183.20
    • 100 ug
    • 10ug
    • 1 mg
    • 200 ug
    • 500 ug
    • 50ug
    • 5 mg
  • Uniprot ID: Inquire
  • Buffer composition: 20mM Tris, 150mM NaCl, pH8.0, containing 1mM EDTA, 1mM DTT, 0.01% SKL, 5% Trehalose and Proclin300.
  • Form: Freeze-dried powder
  • Predicted Molecular Mass (KD): 26.5kDa
  • Isoelectric Point: 6.3
  • Description: Recombinant Human Ciliary Neurotrophic Factor expressed in: E.coli


    Propagation of goat putative spermatogonial stem cells under growth factors defined serum-free culture conditions.

    In the present study, we used a serum-free culture media to propagate goat putative spermatogonial stem cells (SSCs) and evaluated the effect of crucial growth factors on relative expression of some SSC markers and self-renewal related genes. The enriched SSCs were cultured on a homologous Sertoli cell feeder layer in KO-DMEM supplemented with 10% KOSR.

    Putative SSC colonies emerged between day 6 and 10 which were then characterized by the expression of numerous spermatogonial and pluripotency related markers.

    After 15 days of subculture, the relative mRNA expression study revealed that 40 ng/mL concentration of Glial cell line-derived neurotrophic factor (GDNF) upregulated the expression of BCL6B, ID4, PLZF, and UCHL1. Moreover, the supplementation of GDNF + bFGF up-regulated the expression of PLZF and BCL6B. UCHL1 expression was higher after addition of GDNF + LIF while, THY1 overexpressed in response to the addition of GDNF + CSF1. These results demonstrated that the goat SSCs were efficiently propagated using a KOSR based serum-free media and the growth factor supplementation markedly influences their gene expression profile.


    Protective effects of lycopene in cancer, cardiovascular, and neurodegenerative diseases: An update on epidemiological and mechanistic perspectives.

    Recent mechanistic and epidemiological studies have provided insights into health benefits of dietary lycopene to decrease the risk and complications associated with several chronic diseases such as cardiovascular diseases (CVD), obesity, type 2 diabetes, cancer, and neurodegenerative disorders. These chronic diseases are primarily associated with oxidative stress-induced systemic and low-grade chronic inflammation.

    Owing to its potent antioxidant properties, lycopene can potentially alleviate enhanced levels of proinflammatory mediators (e.g., proinflammatory