Neuropilin

The functions and applications of A7R in anti-angiogenic therapy, imaging and drug delivery systems.

Vascular endothelial growth factor receptor 2 (VEGFR-2) and neuropilin-1 (NRP-1) are two prominent antiangiogenic targets. They are highly expressed on vascular endothelial cells and some tumor cells. Therefore, targeting VEGFR-2 and NRP-1 may be a potential antiangiogenic and antitumor strategy. A7R, a peptide with sequence of Ala-Thr-Trp-Leu-Pro-Pro-Arg that was found by phage display of peptide libraries, can preferentially target VEGFR-2 and NRP-1 and destroy the binding between vascular endothelial growth factor 165 (VEGF165) and VEGFR-2 or NRP-1.

This peptide is a new potent inhibitor of tumor angiogenesis and a targeting ligand for cancer therapy. This review describes the discovery, function and mechanism of the action of A7R, and further introduces the applications of A7R in antitumor angiogenic treatments, tumor angiogenesis imaging and targeted drug delivery systems. In this review, strategies to deliver different drugs by A7R-modified liposomes and nanoparticles are highlighted.

A7R, a new dual targeting ligand of VEGFR-2 and NRP-1, is expected to have efficient therapeutic or targeting roles in tumor drug delivery.


Nrp1 is Activated by Konjac Ceramide Binding-Induced Structural Rigidification of the a1a2 Domain.

Konjac ceramide (kCer) is a plant-type ceramide composed of various long-chain bases and a-hydroxyl fatty acids. The presence of d4t,8t-sphingadienine is essential for semaphorin 3A (Sema3A)-like activity. Herein, we examined the three neuropilin 1 (Nrp1) domains (a1a2, b1b2, or c), and found that a1a2 binds to d4t,8t-kCer and possesses Sema3A-like activity. kCer binds to Nrp1 with a weak affinity of mM dissociation constant (Kd). We wondered whether bovine serum albumin could influence the ligand-receptor interaction that a1a2 has with a single high affinity binding site for kCer (Kd in nM range). In the present study we demonstrated the influence of bovine serum albumin.

Thermal denaturation indicates that the a1a2 domain may include intrinsically disordered region (IDR)-like flexibility. A potential interaction site on the a1 module was explored by molecular docking, which revealed a possible Nrp1 activation mechanism, in which kCer binds to Site A close to the Sema3A-binding region of the a1a2 domain. The a1 module then accesses a2 as the IDR-like flexibility becomes ordered via kCer-induced protein rigidity of a1a2.

This induces intramolecular interaction between a1 and a2 through a slight change in protein secondary structure.


Towards identification of novel putative biomarkers for infective endocarditis by serum proteomic analysis.

Infective endocarditis (IE) has high mortality, partly due to delayed diagnosis. No biomarker can identify IE in patients with fever and clinical picture of infection.

To find putative biomarkers we analyzed serum levels of two proteins found in cardiac valves, fibulin-1 (n = 696) and osteoprotegerin (n = 689) among patients on clinical suspicion of IE. Proteomic analyses were performed in 24 patients with bacteremia, 12 patients with definite IE and 12 p.

Neuropilin-1

AP85785 SAB 1mg 2640 EUR

Neuropilin-1

AP86157 SAB 1mg 2640 EUR

Neuropilin-1

AP86273 SAB 1mg 2640 EUR

Neuropilin-1

AP86376 SAB 1mg 2640 EUR

Neuropilin antibody

10R-10590 Fitzgerald 100 ug 418.8 EUR
Description: Mouse monoclonal Neuropilin antibody

Neuropilin antibody

70R-7286 Fitzgerald 50 ug 560.4 EUR
Description: Rabbit polyclonal Neuropilin antibody raised against the N terminal of NETO2

Neuropilin antibody

70R-7424 Fitzgerald 50 ug 560.4 EUR
Description: Rabbit polyclonal Neuropilin antibody raised against the N terminal of NETO2

Neuropilin Antibody

48906 SAB 100ul 499 EUR

Neuropilin-1 Antibody

3856-100 Biovision each 379.2 EUR

Neuropilin-1 Antibody

3856-30T Biovision each 175.2 EUR

Neuropilin-1 Antibody

48906-100ul SAB 100ul 399.6 EUR

Neuropilin-1 Antibody

48906-50ul SAB 50ul 286.8 EUR

Neuropilin-2 Antibody

E19-7604-1 EnoGene 50ug/50ul 145 EUR
Description: Available in various conjugation types.

Neuropilin-2 Antibody

E19-7604-2 EnoGene 100ug/100ul 225 EUR
Description: Available in various conjugation types.

Neuropilin-1 Antibody

E8M0911-6 EnoGene 100ul 225 EUR
Description: Available in various conjugation types.

Neuropilin-1 Antibody

E90493 EnoGene 100μg 255 EUR
Description: Available in various conjugation types.

Neuropilin-1 Antibody

E80902-6 EnoGene 100μl 225 EUR
Description: Available in various conjugation types.

Neuropilin-1 Mouse mAb

E2221356 EnoGene 100ul 225 EUR
Description: Available in various conjugation types.

Neuropilin Rabbit pAb

E2251684 EnoGene 100ul 225 EUR
Description: Available in various conjugation types.

Neuropilin-1 Rabbit mAb

A19087-100ul Abclonal 100 ul 492 EUR

Neuropilin-1 Rabbit mAb

A19087-200ul Abclonal 200 ul 685.2 EUR

Neuropilin-1 Rabbit mAb

A19087-20ul Abclonal 20 ul 265.2 EUR

Neuropilin-1 Rabbit mAb

A19087-50ul Abclonal 50 ul 344.4 EUR

Neuropilin-1 Rabbit pAb

E2382710 EnoGene 100ul 225 EUR
Description: Available in various conjugation types.

Neuropilin-2 Rabbit pAb

E2251852 EnoGene 100ul 225 EUR
Description: Available in various conjugation types.

Neuropilin 1 antibody

70R-12148 Fitzgerald 100 ug 483.6 EUR
Description: Rabbit polyclonal Neuropilin 1 antibody

Neuropilin 1 antibody

70R-50646 Fitzgerald 100 ul 292.8 EUR
Description: Purified Polyclonal Neuropilin 1 antibody

Neuropilin 1 Antibody

48067-100ul SAB 100ul 399.6 EUR

Neuropilin 1 Antibody

48067-50ul SAB 50ul 286.8 EUR

Neuropilin- 2 Antibody

ABD7604 Lifescience Market 100 ug 525.6 EUR

Neuropilin 1 Antibody

R31713 NSJ Bioreagents 100 ug 356.15 EUR
Description: This gene encodes one of two neuropilins, which contain specific protein domains which allow them to participate in several different types of signaling pathways that control cell migration. Neuropilins contain a large N-terminal extracellular domain, made up of complement-binding, coagulation factor V/VIII, and meprin domains. These proteins also contain a short membrane-spanning domain and a small cytoplasmic domain. Neuropilins bind many ligands and various types of co-receptors; they affect cell survival, migration, and attraction. Some of the ligands and co-receptors bound by neuropilins are vascular endothelial growth factor (VEGF) and semaphorin family members. Several alternatively spliced transcript variants that encode different protein isoforms have been described for this gene.

Neuropilin 2 Antibody

E38PA4135 EnoGene 100ul 225 EUR
Description: Available in various conjugation types.

Neuropilin 1 Antibody

E38PA2327 EnoGene 100ul 225 EUR
Description: Available in various conjugation types.

Neuropilin 1 Antibody

48067 SAB 100ul 429 EUR

Rat Neuropilin ELISA kit

E01A15074 BlueGene 96T 700 EUR
Description: ELISA

Neuropilin 1 Rabbit pAb

E2380865 EnoGene 100ul 225 EUR
Description: Available in various conjugation types.

Neuropilin 1 Rabbit mAb

58673 SAB 100ul 339 EUR

Rat Neuropilin-2 ELISA Kit

IRTNRP2KT Innovative research each 702 EUR
Description: Rat Neuropilin-2 ELISA Kit

Neuropilin Blocking Peptide

33R-2574 Fitzgerald 100 ug 216 EUR
Description: A synthetic peptide for use as a blocking control in assays to test for specificity of NETO2 antibody, catalog no. 70R-7424

Neuropilin Blocking Peptide

33R-3329 Fitzgerald 100 ug 216 EUR
Description: A synthetic peptide for use as a blocking control in assays to test for specificity of NETO2 antibody, catalog no. 70R-7286

Neuropilin-1 Blocking Peptide

3856BP-50 Biovision each 183.6 EUR

Neuropilin-2 Blocking Peptide

DF7604-BP Affbiotech 1mg 234 EUR

Goat Neuropilin ELISA kit

E01A49980 BlueGene 96T 700 EUR
Description: ELISA

Neuropilin-1 ELISA Kit| Mouse

EF012898 Lifescience Market 96 Tests 826.8 EUR

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