Neuropilin

The functions and applications of A7R in anti-angiogenic therapy, imaging and drug delivery systems.

Vascular endothelial growth factor receptor 2 (VEGFR-2) and neuropilin-1 (NRP-1) are two prominent antiangiogenic targets. They are highly expressed on vascular endothelial cells and some tumor cells. Therefore, targeting VEGFR-2 and NRP-1 may be a potential antiangiogenic and antitumor strategy. A7R, a peptide with sequence of Ala-Thr-Trp-Leu-Pro-Pro-Arg that was found by phage display of peptide libraries, can preferentially target VEGFR-2 and NRP-1 and destroy the binding between vascular endothelial growth factor 165 (VEGF165) and VEGFR-2 or NRP-1.

This peptide is a new potent inhibitor of tumor angiogenesis and a targeting ligand for cancer therapy. This review describes the discovery, function and mechanism of the action of A7R, and further introduces the applications of A7R in antitumor angiogenic treatments, tumor angiogenesis imaging and targeted drug delivery systems. In this review, strategies to deliver different drugs by A7R-modified liposomes and nanoparticles are highlighted.

A7R, a new dual targeting ligand of VEGFR-2 and NRP-1, is expected to have efficient therapeutic or targeting roles in tumor drug delivery.


Nrp1 is Activated by Konjac Ceramide Binding-Induced Structural Rigidification of the a1a2 Domain.

Konjac ceramide (kCer) is a plant-type ceramide composed of various long-chain bases and a-hydroxyl fatty acids. The presence of d4t,8t-sphingadienine is essential for semaphorin 3A (Sema3A)-like activity. Herein, we examined the three neuropilin 1 (Nrp1) domains (a1a2, b1b2, or c), and found that a1a2 binds to d4t,8t-kCer and possesses Sema3A-like activity. kCer binds to Nrp1 with a weak affinity of mM dissociation constant (Kd). We wondered whether bovine serum albumin could influence the ligand-receptor interaction that a1a2 has with a single high affinity binding site for kCer (Kd in nM range). In the present study we demonstrated the influence of bovine serum albumin.

Thermal denaturation indicates that the a1a2 domain may include intrinsically disordered region (IDR)-like flexibility. A potential interaction site on the a1 module was explored by molecular docking, which revealed a possible Nrp1 activation mechanism, in which kCer binds to Site A close to the Sema3A-binding region of the a1a2 domain. The a1 module then accesses a2 as the IDR-like flexibility becomes ordered via kCer-induced protein rigidity of a1a2.

This induces intramolecular interaction between a1 and a2 through a slight change in protein secondary structure.


Towards identification of novel putative biomarkers for infective endocarditis by serum proteomic analysis.

Infective endocarditis (IE) has high mortality, partly due to delayed diagnosis. No biomarker can identify IE in patients with fever and clinical picture of infection.

To find putative biomarkers we analyzed serum levels of two proteins found in cardiac valves, fibulin-1 (n = 696) and osteoprotegerin (n = 689) among patients on clinical suspicion of IE. Proteomic analyses were performed in 24 patients with bacteremia, 12 patients with definite IE and 12 p.

Neuropilin antibody

70R-7286 50 ug
EUR 467
Description: Rabbit polyclonal Neuropilin antibody raised against the N terminal of NETO2

Neuropilin antibody

70R-7424 50 ug
EUR 467
Description: Rabbit polyclonal Neuropilin antibody raised against the N terminal of NETO2

Neuropilin 1 antibody

70R-12148 100 ug
EUR 403
Description: Rabbit polyclonal Neuropilin 1 antibody

Neuropilin 1 Antibody

48067-100ul 100ul
EUR 333

Neuropilin 1 Antibody

48067-50ul 50ul
EUR 239

Neuropilin Blocking Peptide

33R-2574 100 ug
EUR 180
Description: A synthetic peptide for use as a blocking control in assays to test for specificity of NETO2 antibody, catalog no. 70R-7424

Neuropilin Blocking Peptide

33R-3329 100 ug
EUR 180
Description: A synthetic peptide for use as a blocking control in assays to test for specificity of NETO2 antibody, catalog no. 70R-7286

Neuropilin-1 Antibody

3856-100
EUR 316

Neuropilin-1 Antibody

3856-30T
EUR 146

Neuropilin-1 Antibody

48906-100ul 100ul
EUR 333

Neuropilin-1 Antibody

48906-50ul 50ul
EUR 239

Neuropilin Polyclonal Antibody

41826-100ul 100ul
EUR 252

Neuropilin Polyclonal Antibody

41826-50ul 50ul
EUR 187

Neuropilin-2 Antibody

DF7604 200ul
EUR 304
Description: Neuropilin-2 Antibody detects endogenous levels of total Neuropilin-2.

Neuropilin 1 antibody

70R-50646 100 ul
EUR 244
Description: Purified Polyclonal Neuropilin 1 antibody

Neuropilin Polyclonal Antibody

ABP53183-003ml 0.03ml
EUR 158
  • Immunogen information: Synthesized peptide derived from the Internal region of human Neuropilin
  • Applications tips:
Description: A polyclonal antibody for detection of Neuropilin from Human, Mouse, Rat. This Neuropilin antibody is for WB, IHC-P, ELISA. It is affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogenand is unconjugated. The antibody is produced in rabbit by using as an immunogen synthesized peptide derived from the Internal region of human Neuropilin

Neuropilin Polyclonal Antibody

ABP53183-01ml 0.1ml
EUR 289
  • Immunogen information: Synthesized peptide derived from the Internal region of human Neuropilin
  • Applications tips:
Description: A polyclonal antibody for detection of Neuropilin from Human, Mouse, Rat. This Neuropilin antibody is for WB, IHC-P, ELISA. It is affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogenand is unconjugated. The antibody is produced in rabbit by using as an immunogen synthesized peptide derived from the Internal region of human Neuropilin

Neuropilin Polyclonal Antibody

ABP53183-02ml 0.2ml
EUR 414
  • Immunogen information: Synthesized peptide derived from the Internal region of human Neuropilin
  • Applications tips:
Description: A polyclonal antibody for detection of Neuropilin from Human, Mouse, Rat. This Neuropilin antibody is for WB, IHC-P, ELISA. It is affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogenand is unconjugated. The antibody is produced in rabbit by using as an immunogen synthesized peptide derived from the Internal region of human Neuropilin

Neuropilin- 2 Antibody

ABD7604 100 ug
EUR 438

Neuropilin Polyclonal Antibody

ES4182-100ul 100ul
EUR 279
Description: A Rabbit Polyclonal antibody against Neuropilin from Human/Mouse/Rat. This antibody is tested and validated for WB, ELISA, IHC, WB, ELISA

Neuropilin Polyclonal Antibody

ES4182-50ul 50ul
EUR 207
Description: A Rabbit Polyclonal antibody against Neuropilin from Human/Mouse/Rat. This antibody is tested and validated for WB, ELISA, IHC, WB, ELISA

Anti-Neuropilin antibody

STJ96817 200 µl
EUR 197
Description: Rabbit polyclonal to Neuropilin.

anti-Neuropilin 1

YF-PA15894 100 ug
EUR 403
Description: Rabbit polyclonal to Neuropilin 1

Neuropilin 1 Blocking Peptide

33R-10963 50 ug
EUR 191
Description: A synthetic peptide for use as a blocking control in assays to test for specificity of Neuropilin 1 antibody, catalog no. 70R-12148

Neuropilin-1 Blocking Peptide

3856BP-50
EUR 153

Neuropilin-2 Polyclonal Antibody

41638-100ul 100ul
EUR 252

Neuropilin-2 Polyclonal Antibody

41638-50ul 50ul
EUR 187

Neuropilin-2 Blocking Peptide

DF7604-BP 1mg
EUR 195

Neuropilin 1 (NRP1) Antibody

20-abx008482
  • EUR 300.00
  • EUR 439.00
  • EUR 189.00
  • 100 ul
  • 200 ul
  • 30 ul
  • Shipped within 5-10 working days.

Neuropilin 2 (NRP2) Antibody

abx026336-400ul 400 ul
EUR 523
  • Shipped within 5-10 working days.

Neuropilin 2 (NRP2) Antibody

abx026336-80l 80 µl
EUR 286
  • Shipped within 5-10 working days.

Neuropilin 1 (NRP1) Antibody

abx019142-100ug 100 ug
EUR 342
  • Shipped within 5-10 working days.

Neuropilin 1 (NRP1) Antibody

20-abx004745
  • EUR 411.00
  • EUR 592.00
  • EUR 182.00
  • EUR 314.00
  • 100 ul
  • 200 ul
  • 20 ul
  • 50 ul
  • Shipped within 5-10 working days.

Neuropilin 1 (NRP1) Antibody

abx217245-100ug 100 ug
EUR 439
  • Shipped within 5-10 working days.

Neuropilin 1 (NRP1) Antibody

abx224175-100ug 100 ug
EUR 411
  • Shipped within 5-10 working days.

Neuropilin 1 (NRP1) Antibody

20-abx101004
  • EUR 398.00
  • EUR 133.00
  • EUR 1107.00
  • EUR 537.00
  • EUR 314.00
  • 100 ug
  • 10 ug
  • 1 mg
  • 200 ug
  • 50 ug
  • Shipped within 5-12 working days.

Neuropilin 1 (NRP1) Antibody

20-abx101005
  • EUR 398.00
  • EUR 133.00
  • EUR 1107.00
  • EUR 537.00
  • EUR 314.00
  • 100 ug
  • 10 ug
  • 1 mg
  • 200 ug
  • 50 ug
  • Shipped within 5-12 working days.

Neuropilin 1 (NRP1) Antibody

20-abx101006
  • EUR 411.00
  • EUR 133.00
  • EUR 1135.00
  • EUR 551.00
  • EUR 314.00
  • 100 ug
  • 10 ug
  • 1 mg
  • 200 ug
  • 50 ug
  • Shipped within 5-7 working days.

Neuropilin 1 (NRP1) Antibody

20-abx101007
  • EUR 411.00
  • EUR 133.00
  • EUR 1135.00
  • EUR 551.00
  • EUR 314.00
  • 100 ug
  • 10 ug
  • 1 mg
  • 200 ug
  • 50 ug
  • Shipped within 5-7 working days.

Neuropilin 1 (NRP1) Antibody

20-abx101008
  • EUR 411.00
  • EUR 133.00
  • EUR 1135.00
  • EUR 551.00
  • EUR 314.00
  • 100 ug
  • 10 ug
  • 1 mg
  • 200 ug
  • 50 ug
  • Shipped within 5-7 working days.

Neuropilin 1 (NRP1) Antibody

20-abx101009
  • EUR 411.00
  • EUR 133.00
  • EUR 1135.00
  • EUR 551.00
  • EUR 314.00
  • 100 ug
  • 10 ug
  • 1 mg
  • 200 ug
  • 50 ug
  • Shipped within 5-7 working days.

Neuropilin 1 (NRP1) Antibody

20-abx101010
  • EUR 425.00
  • EUR 133.00
  • EUR 1177.00
  • EUR 578.00
  • EUR 328.00
  • 100 ug
  • 10 ug
  • 1 mg
  • 200 ug
  • 50 ug
  • Shipped within 5-7 working days.

Neuropilin 1 (NRP1) Antibody

20-abx101011
  • EUR 425.00
  • EUR 133.00
  • EUR 1177.00
  • EUR 578.00
  • EUR 328.00
  • 100 ug
  • 10 ug
  • 1 mg
  • 200 ug
  • 50 ug
  • Shipped within 5-12 working days.

Neuropilin 1 (NRP1) Antibody

20-abx101012
  • EUR 425.00
  • EUR 133.00
  • EUR 1177.00
  • EUR 578.00
  • EUR 328.00
  • 100 ug
  • 10 ug
  • 1 mg
  • 200 ug
  • 50 ug
  • Shipped within 5-7 working days.