Neuropilin

The functions and applications of A7R in anti-angiogenic therapy, imaging and drug delivery systems.

Vascular endothelial growth factor receptor 2 (VEGFR-2) and neuropilin-1 (NRP-1) are two prominent antiangiogenic targets. They are highly expressed on vascular endothelial cells and some tumor cells. Therefore, targeting VEGFR-2 and NRP-1 may be a potential antiangiogenic and antitumor strategy. A7R, a peptide with sequence of Ala-Thr-Trp-Leu-Pro-Pro-Arg that was found by phage display of peptide libraries, can preferentially target VEGFR-2 and NRP-1 and destroy the binding between vascular endothelial growth factor 165 (VEGF165) and VEGFR-2 or NRP-1.

This peptide is a new potent inhibitor of tumor angiogenesis and a targeting ligand for cancer therapy. This review describes the discovery, function and mechanism of the action of A7R, and further introduces the applications of A7R in antitumor angiogenic treatments, tumor angiogenesis imaging and targeted drug delivery systems. In this review, strategies to deliver different drugs by A7R-modified liposomes and nanoparticles are highlighted.

A7R, a new dual targeting ligand of VEGFR-2 and NRP-1, is expected to have efficient therapeutic or targeting roles in tumor drug delivery.


Nrp1 is Activated by Konjac Ceramide Binding-Induced Structural Rigidification of the a1a2 Domain.

Konjac ceramide (kCer) is a plant-type ceramide composed of various long-chain bases and a-hydroxyl fatty acids. The presence of d4t,8t-sphingadienine is essential for semaphorin 3A (Sema3A)-like activity. Herein, we examined the three neuropilin 1 (Nrp1) domains (a1a2, b1b2, or c), and found that a1a2 binds to d4t,8t-kCer and possesses Sema3A-like activity. kCer binds to Nrp1 with a weak affinity of mM dissociation constant (Kd). We wondered whether bovine serum albumin could influence the ligand-receptor interaction that a1a2 has with a single high affinity binding site for kCer (Kd in nM range). In the present study we demonstrated the influence of bovine serum albumin.

Thermal denaturation indicates that the a1a2 domain may include intrinsically disordered region (IDR)-like flexibility. A potential interaction site on the a1 module was explored by molecular docking, which revealed a possible Nrp1 activation mechanism, in which kCer binds to Site A close to the Sema3A-binding region of the a1a2 domain. The a1 module then accesses a2 as the IDR-like flexibility becomes ordered via kCer-induced protein rigidity of a1a2.

This induces intramolecular interaction between a1 and a2 through a slight change in protein secondary structure.


Towards identification of novel putative biomarkers for infective endocarditis by serum proteomic analysis.

Infective endocarditis (IE) has high mortality, partly due to delayed diagnosis. No biomarker can identify IE in patients with fever and clinical picture of infection.

To find putative biomarkers we analyzed serum levels of two proteins found in cardiac valves, fibulin-1 (n = 696) and osteoprotegerin (n = 689) among patients on clinical suspicion of IE. Proteomic analyses were performed in 24 patients with bacteremia, 12 patients with definite IE and 12 p.

Neuropilin antibody

70R-7424 Fitzgerald 50 ug 467 EUR
Description: Rabbit polyclonal Neuropilin antibody raised against the N terminal of NETO2

Neuropilin Polyclonal Antibody

ES4182-100ul ELK Biotech 100ul 279 EUR
Description: A Rabbit Polyclonal antibody against Neuropilin from Human/Mouse/Rat. This antibody is tested and validated for WB, ELISA, IHC, WB, ELISA

Neuropilin Polyclonal Antibody

ES4182-50ul ELK Biotech 50ul 207 EUR
Description: A Rabbit Polyclonal antibody against Neuropilin from Human/Mouse/Rat. This antibody is tested and validated for WB, ELISA, IHC, WB, ELISA

Neuropilin Polyclonal Antibody

ABP53183-003ml Abbkine 0.03ml 158 EUR
Description: A polyclonal antibody for detection of Neuropilin from Human, Mouse, Rat. This Neuropilin antibody is for WB, IHC-P, ELISA. It is affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogenand is unconjugated. The antibody is produced in rabbit by using as an immunogen synthesized peptide derived from the Internal region of human Neuropilin

Neuropilin Polyclonal Antibody

ABP53183-01ml Abbkine 0.1ml 289 EUR
Description: A polyclonal antibody for detection of Neuropilin from Human, Mouse, Rat. This Neuropilin antibody is for WB, IHC-P, ELISA. It is affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogenand is unconjugated. The antibody is produced in rabbit by using as an immunogen synthesized peptide derived from the Internal region of human Neuropilin

Neuropilin Polyclonal Antibody

ABP53183-02ml Abbkine 0.2ml 414 EUR
Description: A polyclonal antibody for detection of Neuropilin from Human, Mouse, Rat. This Neuropilin antibody is for WB, IHC-P, ELISA. It is affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogenand is unconjugated. The antibody is produced in rabbit by using as an immunogen synthesized peptide derived from the Internal region of human Neuropilin

Anti-Neuropilin antibody

STJ96817 St John's Laboratory 200 ┬Ál 197 EUR
Description: Rabbit polyclonal to Neuropilin.

Neuropilin 1 Antibody

48067-100ul SAB 100ul 333 EUR

Neuropilin 1 Antibody

48067-50ul SAB 50ul 239 EUR

Neuropilin-1 Antibody

48906-100ul SAB 100ul 333 EUR

Neuropilin-1 Antibody

48906-50ul SAB 50ul 239 EUR

Neuropilin Polyclonal Antibody

41826-100ul SAB 100ul 252 EUR

Neuropilin Polyclonal Antibody

41826-50ul SAB 50ul 187 EUR

Neuropilin-2 Antibody

DF7604 Affbiotech 200ul 304 EUR
Description: Neuropilin-2 Antibody detects endogenous levels of total Neuropilin-2.

Neuropilin- 2 Antibody

ABD7604 Lifescience Market 100 ug 438 EUR

Neuropilin-1 Antibody

3856-100 Biovision 316 EUR

Neuropilin-1 Antibody

3856-30T Biovision 146 EUR

anti-Neuropilin 1

YF-PA15894 Abfrontier 100 ug 403 EUR
Description: Rabbit polyclonal to Neuropilin 1

Neuropilin Blocking Peptide

33R-2574 Fitzgerald 100 ug 180 EUR
Description: A synthetic peptide for use as a blocking control in assays to test for specificity of NETO2 antibody, catalog no. 70R-7424

Neuropilin Blocking Peptide

33R-3329 Fitzgerald 100 ug 180 EUR
Description: A synthetic peptide for use as a blocking control in assays to test for specificity of NETO2 antibody, catalog no. 70R-7286

Neuropilin 1 antibody

70R-12148 Fitzgerald 100 ug 403 EUR
Description: Rabbit polyclonal Neuropilin 1 antibody

Neuropilin 1 antibody

70R-50646 Fitzgerald 100 ul 244 EUR
Description: Purified Polyclonal Neuropilin 1 antibody

Neuropilin-2 Polyclonal Antibody

ES7884-100ul ELK Biotech 100ul 279 EUR
Description: A Rabbit Polyclonal antibody against Neuropilin-2 from Human/Mouse/Rat. This antibody is tested and validated for WB, ELISA, WB, ELISA

Neuropilin-2 Polyclonal Antibody

ES7884-50ul ELK Biotech 50ul 207 EUR
Description: A Rabbit Polyclonal antibody against Neuropilin-2 from Human/Mouse/Rat. This antibody is tested and validated for WB, ELISA, WB, ELISA

Neuropilin-2 Polyclonal Antibody

ES3960-100ul ELK Biotech 100ul 279 EUR
Description: A Rabbit Polyclonal antibody against Neuropilin-2 from Human/Mouse/Rat. This antibody is tested and validated for WB, ELISA, IHC, WB, ELISA

Neuropilin-2 Polyclonal Antibody

ES3960-50ul ELK Biotech 50ul 207 EUR
Description: A Rabbit Polyclonal antibody against Neuropilin-2 from Human/Mouse/Rat. This antibody is tested and validated for WB, ELISA, IHC, WB, ELISA

Neuropilin-1 Polyclonal Antibody

ES2934-100ul ELK Biotech 100ul 279 EUR
Description: A Rabbit Polyclonal antibody against Neuropilin-1 from Human/Mouse/Rat. This antibody is tested and validated for WB, ELISA, IHC, WB, ELISA

Neuropilin-1 Polyclonal Antibody

ES2934-50ul ELK Biotech 50ul 207 EUR
Description: A Rabbit Polyclonal antibody against Neuropilin-1 from Human/Mouse/Rat. This antibody is tested and validated for WB, ELISA, IHC, WB, ELISA

Neuropilin 1 (NRP1) Antibody

20-abx131786 Abbexa
  • 314.00 EUR
  • 787.00 EUR
  • 411.00 EUR
  • 154.00 EUR
  • 258.00 EUR
  • 100 ug
  • 1 mg
  • 200 ug
  • 20 ug
  • 50 ug

Neuropilin 2 (NRP2) Antibody

20-abx128984 Abbexa
  • 425.00 EUR
  • 133.00 EUR
  • 1205.00 EUR
  • 578.00 EUR
  • 328.00 EUR
  • 100 ug
  • 10 ug
  • 1 mg
  • 200 ug
  • 50 ug

Neuropilin 1 (NRP1) Antibody

20-abx130134 Abbexa
  • 425.00 EUR
  • 133.00 EUR
  • 1177.00 EUR
  • 578.00 EUR
  • 328.00 EUR
  • 100 ug
  • 10 ug
  • 1 mg
  • 200 ug
  • 50 ug

Neuropilin 2 (NRP1) Antibody

20-abx121650 Abbexa
  • 300.00 EUR
  • 439.00 EUR
  • 189.00 EUR
  • 100 ul
  • 200 ul
  • 30 ul

Neuropilin 1 (NRP1) Antibody

20-abx114089 Abbexa
  • 732.00 EUR
  • 398.00 EUR
  • 150 ul
  • 50 ul

Neuropilin-2 Polyclonal Antibody

ABP52961-003ml Abbkine 0.03ml 158 EUR
Description: A polyclonal antibody for detection of Neuropilin-2 from Human, Mouse, Rat. This Neuropilin-2 antibody is for WB, IHC-P, ELISA. It is affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogenand is unconjugated. The antibody is produced in rabbit by using as an immunogen synthesized peptide derived from the Internal region of human Neuropilin-2

Neuropilin-2 Polyclonal Antibody

ABP52961-01ml Abbkine 0.1ml 289 EUR
Description: A polyclonal antibody for detection of Neuropilin-2 from Human, Mouse, Rat. This Neuropilin-2 antibody is for WB, IHC-P, ELISA. It is affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogenand is unconjugated. The antibody is produced in rabbit by using as an immunogen synthesized peptide derived from the Internal region of human Neuropilin-2

Neuropilin-2 Polyclonal Antibody

ABP52961-02ml Abbkine 0.2ml 414 EUR
Description: A polyclonal antibody for detection of Neuropilin-2 from Human, Mouse, Rat. This Neuropilin-2 antibody is for WB, IHC-P, ELISA. It is affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogenand is unconjugated. The antibody is produced in rabbit by using as an immunogen synthesized peptide derived from the Internal region of human Neuropilin-2

Neuropilin-1 Polyclonal Antibody

ABP51935-003ml Abbkine 0.03ml 158 EUR
Description: A polyclonal antibody for detection of Neuropilin-1 from Human, Mouse, Rat. This Neuropilin-1 antibody is for WB, IHC-P, ELISA. It is affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogenand is unconjugated. The antibody is produced in rabbit by using as an immunogen synthesized peptide derived from the Internal region of human Neuropilin-1

Neuropilin-1 Polyclonal Antibody

ABP51935-01ml Abbkine 0.1ml 289 EUR
Description: A polyclonal antibody for detection of Neuropilin-1 from Human, Mouse, Rat. This Neuropilin-1 antibody is for WB, IHC-P, ELISA. It is affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogenand is unconjugated. The antibody is produced in rabbit by using as an immunogen synthesized peptide derived from the Internal region of human Neuropilin-1

Neuropilin-1 Polyclonal Antibody

ABP51935-02ml Abbkine 0.2ml 414 EUR
Description: A polyclonal antibody for detection of Neuropilin-1 from Human, Mouse, Rat. This Neuropilin-1 antibody is for WB, IHC-P, ELISA. It is affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogenand is unconjugated. The antibody is produced in rabbit by using as an immunogen synthesized peptide derived from the Internal region of human Neuropilin-1

Neuropilin 1 (NRP1) Antibody

20-abx101004 Abbexa
  • 398.00 EUR
  • 133.00 EUR
  • 1107.00 EUR
  • 537.00 EUR
  • 314.00 EUR
  • 100 ug
  • 10 ug
  • 1 mg
  • 200 ug
  • 50 ug

Neuropilin 1 (NRP1) Antibody

20-abx101005 Abbexa
  • 398.00 EUR
  • 133.00 EUR
  • 1107.00 EUR
  • 537.00 EUR
  • 314.00 EUR
  • 100 ug
  • 10 ug
  • 1 mg
  • 200 ug
  • 50 ug

Neuropilin 1 (NRP1) Antibody

20-abx101006 Abbexa
  • 411.00 EUR
  • 133.00 EUR
  • 1135.00 EUR
  • 551.00 EUR
  • 314.00 EUR
  • 100 ug
  • 10 ug
  • 1 mg
  • 200 ug
  • 50 ug

Neuropilin 1 (NRP1) Antibody

20-abx101007 Abbexa
  • 411.00 EUR
  • 133.00 EUR
  • 1135.00 EUR
  • 551.00 EUR
  • 314.00 EUR
  • 100 ug
  • 10 ug
  • 1 mg
  • 200 ug
  • 50 ug

Neuropilin 1 (NRP1) Antibody

20-abx101008 Abbexa
  • 411.00 EUR
  • 133.00 EUR
  • 1135.00 EUR
  • 551.00 EUR
  • 314.00 EUR
  • 100 ug
  • 10 ug
  • 1 mg
  • 200 ug
  • 50 ug

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