Neuronal

The protective effect of metformin on mitochondrial dysfunction and endoplasmic reticulum stress in diabetic mice brain.

Diabetes is a metabolic disorder associated with mitochondrial (mt) dysfunction and oxidative stress. The molecular mechanisms involved in diabetes-associated neurological complications remain elusive. This study aims to investigate the protective effect of metformin (MF) on regulatory networks and integrated stress responses in brain tissue of Streptozotocin (STZ)-induced diabetic mice. STZ-induced diabetic mice were treated with MF (20 mg/kg BW), and whole brain tissue was harvested for further analysis. Protein carbonylation was measured as a marker of neuronal oxidative stress. Protein expression of mt chaperones, maintenance proteins, and regulators of the unfolded protein response (UPR) were measured by Western blot. Transcript levels of antioxidant enzyme GSTA4; mt biogenesis markers, ER stress regulators, and miR-132 and miR-148a were analysed using qPCR.

The results showed that MF efficiently reduced protein carbonylation and oxidation. Mt function was improved by MF-treatment through upregulation of chaperone proteins (HSP60, HSP70 and LonP1). MF elicits the UPR to attenuate ER stress through a miR-132 repression mechanism. Additionally, MF was found to elevate deacetylases- Sirt1, Sirt3; and mt biogenesis marker PGC-1α through miR-148a repression. This is the first study to demonstrate the epigenetic regulation of mt maintenance by MF in diabetic C57BL/6 mouse whole brain tissue. We thus conclude that MF, beyond its anti-hyperglycaemic role, mediates neuroprotection through epigenomic and integrated stress responses in diabetic mice.

Recombinant Cadherin, Neuronal (CDH2)

4-RPB481Mu01 Cloud-Clone
  • 472.74 EUR
  • 229.00 EUR
  • 1497.76 EUR
  • 565.92 EUR
  • 1031.84 EUR
  • 379.00 EUR
  • 3594.40 EUR
  • 100 ug
  • 10ug
  • 1 mg
  • 200 ug
  • 500 ug
  • 50ug
  • 5 mg
Description: Recombinant Mouse Cadherin, Neuronal expressed in: E.coli

Recombinant Cadherin, Neuronal (CDH2)

4-RPB481Mu02 Cloud-Clone
  • 472.74 EUR
  • 229.00 EUR
  • 1497.76 EUR
  • 565.92 EUR
  • 1031.84 EUR
  • 379.00 EUR
  • 3594.40 EUR
  • 100 ug
  • 10ug
  • 1 mg
  • 200 ug
  • 500 ug
  • 50ug
  • 5 mg
Description: Recombinant Mouse Cadherin, Neuronal expressed in: E.coli

Recombinant Cadherin, Neuronal (CDH2)

4-RPB481Ra01 Cloud-Clone
  • 503.20 EUR
  • 238.00 EUR
  • 1612.00 EUR
  • 604.00 EUR
  • 1108.00 EUR
  • 400.00 EUR
  • 3880.00 EUR
  • 100 ug
  • 10ug
  • 1 mg
  • 200 ug
  • 500 ug
  • 50ug
  • 5 mg
Description: Recombinant Rat Cadherin, Neuronal expressed in: E.coli

Recombinant Cadherin, Neuronal (CDH2)

4-RPB481Ra02 Cloud-Clone
  • 503.20 EUR
  • 238.00 EUR
  • 1612.00 EUR
  • 604.00 EUR
  • 1108.00 EUR
  • 400.00 EUR
  • 3880.00 EUR
  • 100 ug
  • 10ug
  • 1 mg
  • 200 ug
  • 500 ug
  • 50ug
  • 5 mg
Description: Recombinant Rat Cadherin, Neuronal expressed in: E.coli

Recombinant Cadherin, Neuronal (CDH2)

4-RPB481Ra03 Cloud-Clone
  • 503.20 EUR
  • 238.00 EUR
  • 1612.00 EUR
  • 604.00 EUR
  • 1108.00 EUR
  • 400.00 EUR
  • 3880.00 EUR
  • 100 ug
  • 10ug
  • 1 mg
  • 200 ug
  • 500 ug
  • 50ug
  • 5 mg
Description: Recombinant Rat Cadherin, Neuronal expressed in: E.coli

Neuronal PAS1 Polyclonal Antibody

ES6410-100ul ELK Biotech 100ul 279 EUR
Description: A Rabbit Polyclonal antibody against Neuronal PAS1 from Human. This antibody is tested and validated for WB, ELISA, WB, ELISA

Neuronal PAS1 Polyclonal Antibody

ES6410-50ul ELK Biotech 50ul 207 EUR
Description: A Rabbit Polyclonal antibody against Neuronal PAS1 from Human. This antibody is tested and validated for WB, ELISA, WB, ELISA

Cadherin, Neuronal (CDH2) Antibody

20-abx125650 Abbexa
  • 411.00 EUR
  • 592.00 EUR
  • 182.00 EUR
  • 314.00 EUR
  • 100 ul
  • 200 ul
  • 20 ul
  • 50 ul

Cadherin, Neuronal (CDH2) Antibody

20-abx128572 Abbexa
  • 411.00 EUR
  • 133.00 EUR
  • 1149.00 EUR
  • 565.00 EUR
  • 314.00 EUR
  • 100 ug
  • 10 ug
  • 1 mg
  • 200 ug
  • 50 ug

Cadherin, Neuronal (CDH2) Antibody

20-abx130190 Abbexa
  • 439.00 EUR
  • 133.00 EUR
  • 1247.00 EUR
  • 592.00 EUR
  • 328.00 EUR
  • 100 ug
  • 10 ug
  • 1 mg
  • 200 ug
  • 50 ug

Cadherin, Neuronal (CDH2) Antibody

20-abx130191 Abbexa
  • 439.00 EUR
  • 133.00 EUR
  • 1247.00 EUR
  • 592.00 EUR
  • 328.00 EUR
  • 100 ug
  • 10 ug
  • 1 mg
  • 200 ug
  • 50 ug

Cadherin, Neuronal (CDH2) Antibody

20-abx119088 Abbexa
  • 314.00 EUR
  • 98.00 EUR
  • 398.00 EUR
  • 495.00 EUR
  • 100 ug
  • 10 ug
  • 200 ug
  • 300 µg

Neuronal Pentraxin Ii Antibody

20-abx114085 Abbexa
  • 732.00 EUR
  • 398.00 EUR
  • 150 ul
  • 50 ul

Cadherin, Neuronal (CDH2) Antibody

20-abx111293 Abbexa
  • 732.00 EUR
  • 398.00 EUR
  • 150 ul
  • 50 ul

Neuronal PAS1 Polyclonal Antibody

ABP55411-003ml Abbkine 0.03ml 158 EUR
Description: A polyclonal antibody for detection of Neuronal PAS1 from Human. This Neuronal PAS1 antibody is for WB, ELISA. It is affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogenand is unconjugated. The antibody is produced in rabbit by using as an immunogen synthesized peptide derived from the C-terminal region of human Neuronal PAS1 at AA range: 420-500

Neuronal PAS1 Polyclonal Antibody

ABP55411-01ml Abbkine 0.1ml 289 EUR
Description: A polyclonal antibody for detection of Neuronal PAS1 from Human. This Neuronal PAS1 antibody is for WB, ELISA. It is affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogenand is unconjugated. The antibody is produced in rabbit by using as an immunogen synthesized peptide derived from the C-terminal region of human Neuronal PAS1 at AA range: 420-500

Neuronal PAS1 Polyclonal Antibody

ABP55411-02ml Abbkine 0.2ml 414 EUR
Description: A polyclonal antibody for detection of Neuronal PAS1 from Human. This Neuronal PAS1 antibody is for WB, ELISA. It is affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogenand is unconjugated. The antibody is produced in rabbit by using as an immunogen synthesized peptide derived from the C-terminal region of human Neuronal PAS1 at AA range: 420-500

Cadherin, Neuronal (CDH2) Antibody

20-abx002200 Abbexa
  • 411.00 EUR
  • 592.00 EUR
  • 182.00 EUR
  • 314.00 EUR
  • 100 ul
  • 200 ul
  • 20 ul
  • 50 ul

Cadherin, Neuronal (CDH2) Antibody

20-abx101717 Abbexa
  • 411.00 EUR
  • 133.00 EUR
  • 1149.00 EUR
  • 565.00 EUR
  • 314.00 EUR
  • 100 ug
  • 10 ug
  • 1 mg
  • 200 ug
  • 50 ug

Cadherin, Neuronal (CDH2) Antibody

20-abx101718 Abbexa
  • 425.00 EUR
  • 133.00 EUR
  • 1177.00 EUR
  • 578.00 EUR
  • 328.00 EUR
  • 100 ug
  • 10 ug
  • 1 mg
  • 200 ug
  • 50 ug

Cadherin, Neuronal (CDH2) Antibody

20-abx101719 Abbexa
  • 425.00 EUR
  • 133.00 EUR
  • 1177.00 EUR
  • 578.00 EUR
  • 328.00 EUR
  • 100 ug
  • 10 ug
  • 1 mg
  • 200 ug
  • 50 ug

Cadherin, Neuronal (CDH2) Antibody

20-abx101720 Abbexa
  • 425.00 EUR
  • 133.00 EUR
  • 1177.00 EUR
  • 578.00 EUR
  • 328.00 EUR
  • 100 ug
  • 10 ug
  • 1 mg
  • 200 ug
  • 50 ug

Cadherin, Neuronal (CDH2) Antibody

20-abx101721 Abbexa
  • 439.00 EUR
  • 133.00 EUR
  • 1247.00 EUR
  • 592.00 EUR
  • 328.00 EUR
  • 100 ug
  • 10 ug
  • 1 mg
  • 200 ug
  • 50 ug

Neuronal Specific Enolase (Recombinant)

20-abx073283 Abbexa
  • 3418.00 EUR
  • 328.00 EUR
  • 230.00 EUR
  • 1 mg
  • 25 ug
  • 5 ug

Neuronal Specific Enolase Enzyme

20-abx073672 Abbexa
  • 328.00 EUR
  • 6341.00 EUR
  • 230.00 EUR
  • 10 ug
  • 1 mg
  • 2 µg

Cadherin, Neuronal (CDH2) Antibody

abx146155-100ug Abbexa 100 ug 391 EUR

Neuronal Specific Enolase Antibody

20-abx137335 Abbexa
  • 704.00 EUR
  • 328.00 EUR
  • 230.00 EUR
  • 100 ug
  • 20 ug
  • 5 ug

Cadherin, Neuronal (CDH2) Antibody

abx015808-100ul Abbexa 100 ul 411 EUR

Non-Neuronal Enolase Antibody

abx020643-1mg Abbexa 1 mg 815 EUR

neuronal pentraxin 1 Antibody

abx433029-200ul Abbexa 200 ul 384 EUR

Cadherin, Neuronal (CDH2) Antibody

20-abx214339 Abbexa
  • 411.00 EUR
  • 300.00 EUR
  • 100 ul
  • 50 ul

Cadherin, Neuronal (CDH2) Antibody

20-abx171504 Abbexa
  • 815.00 EUR
  • 425.00 EUR
  • 1 mg
  • 200 ug

Cadherin, Neuronal (CDH2) Antibody

20-abx329244 Abbexa
  • 314.00 EUR
  • 244.00 EUR
  • 100 ug
  • 50 ug

Anti-Neuronal PAS1 antibody

STJ94436 St John's Laboratory 200 µl 197 EUR
Description: Rabbit polyclonal to Neuronal PAS1.

DiscoveryProbe? Neuronal Signaling Library

L1026-.1 ApexBio 100 uL/well(10 mM solution) 4968 EUR

DiscoveryProbe? Neuronal Signaling Library

L1026-.25 ApexBio 250 uL/well(10 mM solution) 8866 EUR

DiscoveryProbe? Neuronal Signaling Library

L1026-5 ApexBio 5 mg/well 11534 EUR

Non Neuronal Enolase antibody

10R-8640 Fitzgerald 100 ul 393 EUR
Description: Mouse monoclonal Non Neuronal Enolase antibody

Non Neuronal Enolase antibody

10R-8641 Fitzgerald 100 ul 393 EUR
Description: Mouse monoclonal Non Neuronal Enolase antibody

neuronal pentraxin 1 Peptide

43-393P ProSci 0.1 mg 338 EUR

Recombinant Neuronal Pentraxin I (NPTX1)

4-RPA298Hu01 Cloud-Clone
  • 521.12 EUR
  • 242.00 EUR
  • 1679.20 EUR
  • 626.40 EUR
  • 1152.80 EUR
  • 412.00 EUR
  • 4048.00 EUR
  • 100 ug
  • 10ug
  • 1 mg
  • 200 ug
  • 500 ug
  • 50ug
  • 5 mg
Description: Recombinant Human Neuronal Pentraxin I expressed in: E.coli

Recombinant Neuronal Pentraxin I (NPTX1)

4-RPA298Mu01 Cloud-Clone
  • 530.08 EUR
  • 245.00 EUR
  • 1712.80 EUR
  • 637.60 EUR
  • 1175.20 EUR
  • 418.00 EUR
  • 4132.00 EUR
  • 100 ug
  • 10ug
  • 1 mg
  • 200 ug
  • 500 ug
  • 50ug
  • 5 mg
Description: Recombinant Mouse Neuronal Pentraxin I expressed in: E.coli

Recombinant Neuronal Pentraxin II (NPTX2)

4-RPA299Hu01 Cloud-Clone
  • 470.94 EUR
  • 229.00 EUR
  • 1491.04 EUR
  • 563.68 EUR
  • 1027.36 EUR
  • 378.00 EUR
  • 3577.60 EUR
  • 100 ug
  • 10ug
  • 1 mg
  • 200 ug
  • 500 ug
  • 50ug
  • 5 mg
Description: Recombinant Human Neuronal Pentraxin II expressed in: E.coli

Recombinant Enolase, Non Neuronal (NNE)

4-RPB449Bo01 Cloud-Clone
  • 476.32 EUR
  • 230.00 EUR
  • 1511.20 EUR
  • 570.40 EUR
  • 1040.80 EUR
  • 382.00 EUR
  • 3628.00 EUR
  • 100 ug
  • 10ug
  • 1 mg
  • 200 ug
  • 500 ug
  • 50ug
  • 5 mg
Description: Recombinant Bovine Enolase, Non Neuronal expressed in: E.coli

Recombinant Enolase, Non Neuronal (NNE)

4-RPB449Hu01 Cloud-Clone
  • 476.32 EUR
  • 230.00 EUR
  • 1511.20 EUR
  • 570.40 EUR
  • 1040.80 EUR
  • 382.00 EUR
  • 3628.00 EUR
  • 100 ug
  • 10ug
  • 1 mg
  • 200 ug
  • 500 ug
  • 50ug
  • 5 mg
Description: Recombinant Human Enolase, Non Neuronal expressed in: E.coli

Recombinant Enolase, Non Neuronal (NNE)

4-RPB449Hu02 Cloud-Clone
  • 476.32 EUR
  • 230.00 EUR
  • 1511.20 EUR
  • 570.40 EUR
  • 1040.80 EUR
  • 382.00 EUR
  • 3628.00 EUR
  • 100 ug
  • 10ug
  • 1 mg
  • 200 ug
  • 500 ug
  • 50ug
  • 5 mg
Description: Recombinant Human Enolase, Non Neuronal expressed in: E.coli

Recombinant Enolase, Non Neuronal (NNE)

4-RPB449Hu03 Cloud-Clone
  • 476.32 EUR
  • 230.00 EUR
  • 1511.20 EUR
  • 570.40 EUR
  • 1040.80 EUR
  • 382.00 EUR
  • 3628.00 EUR
  • 100 ug
  • 10ug
  • 1 mg
  • 200 ug
  • 500 ug
  • 50ug
  • 5 mg
Description: Recombinant Human Enolase, Non Neuronal expressed in: E.coli

Recombinant Enolase, Non Neuronal (NNE)

4-RPB449Mu01 Cloud-Clone
  • 413.60 EUR
  • 214.00 EUR
  • 1276.00 EUR
  • 492.00 EUR
  • 884.00 EUR
  • 340.00 EUR
  • 3040.00 EUR
  • 100 ug
  • 10ug
  • 1 mg
  • 200 ug
  • 500 ug
  • 50ug
  • 5 mg
Description: Recombinant Mouse Enolase, Non Neuronal expressed in: E.coli

Anti-nNOS (neuronal)/NOS1 Antibody

PA1329 BosterBio 100ug/vial 334 EUR

nNOS (Neuronal Nitric Oxide Synthase)

RA19011 Neuromics 100 uL 376 EUR

Anti-nNOS (neuronal)/NOS1 Antibody

A01070 BosterBio 100ug/vial 294 EUR

Neuronal Pentraxin-2 (NPTX2) Antibody

20-abx126271 Abbexa
  • 411.00 EUR
  • 592.00 EUR
  • 182.00 EUR
  • 314.00 EUR
  • 100 ul
  • 200 ul
  • 20 ul
  • 50 ul

Neuronal Pentraxin II (NPTX2) Antibody

20-abx128686 Abbexa
  • 398.00 EUR
  • 133.00 EUR
  • 1107.00 EUR
  • 537.00 EUR
  • 314.00 EUR
  • 100 ug
  • 10 ug
  • 1 mg
  • 200 ug
  • 50 ug

Tropomodulin 2 (Neuronal) (TMOD2) Antibody

20-abx116304 Abbexa
  • 732.00 EUR
  • 398.00 EUR
  • 150 ul
  • 50 ul

Neuronal Pentraxin I (NPTX1) Antibody

20-abx114084 Abbexa
  • 732.00 EUR
  • 398.00 EUR
  • 150 ul
  • 50 ul

Neuronal Pentraxin-2 (NPTX2) Antibody

20-abx123794 Abbexa
  • 411.00 EUR
  • 592.00 EUR
  • 100 ul
  • 200 ul

Enolase, Non Neuronal (NNE) Antibody

20-abx102014 Abbexa
  • 467.00 EUR
  • 133.00 EUR
  • 1358.00 EUR
  • 648.00 EUR
  • 356.00 EUR
  • 100 ug
  • 10 ug
  • 1 mg
  • 200 ug
  • 50 ug

Enolase, Non Neuronal (NNE) Antibody

20-abx102015 Abbexa
  • 411.00 EUR
  • 133.00 EUR
  • 1149.00 EUR
  • 565.00 EUR
  • 314.00 EUR
  • 100 ug
  • 10 ug
  • 1 mg
  • 200 ug
  • 50 ug

Enolase, Non Neuronal (NNE) Antibody

20-abx102016 Abbexa
  • 411.00 EUR
  • 133.00 EUR
  • 1149.00 EUR
  • 565.00 EUR
  • 314.00 EUR
  • 100 ug
  • 10 ug
  • 1 mg
  • 200 ug
  • 50 ug

Enolase, Non Neuronal (NNE) Antibody

20-abx102017 Abbexa
  • 411.00 EUR
  • 133.00 EUR
  • 1149.00 EUR
  • 565.00 EUR
  • 314.00 EUR
  • 100 ug
  • 10 ug
  • 1 mg
  • 200 ug
  • 50 ug

Enolase, Non Neuronal (NNE) Antibody

20-abx102018 Abbexa
  • 425.00 EUR
  • 133.00 EUR
  • 1177.00 EUR
  • 578.00 EUR
  • 328.00 EUR
  • 100 ug
  • 10 ug
  • 1 mg
  • 200 ug
  • 50 ug

Neuronal Pentraxin I (NPTX1) Antibody

20-abx102176 Abbexa
  • 398.00 EUR
  • 133.00 EUR
  • 1107.00 EUR
  • 537.00 EUR
  • 314.00 EUR
  • 100 ug
  • 10 ug
  • 1 mg
  • 200 ug
  • 50 ug

Neuronal Pentraxin I (NPTX1) Antibody

20-abx102177 Abbexa
  • 411.00 EUR
  • 133.00 EUR
  • 1135.00 EUR
  • 551.00 EUR
  • 314.00 EUR
  • 100 ug
  • 10 ug
  • 1 mg
  • 200 ug
  • 50 ug

Human Cadherin, Neuronal (CDH2) Protein

20-abx065643 Abbexa
  • 648.00 EUR
  • 272.00 EUR
  • 1998.00 EUR
  • 773.00 EUR
  • 467.00 EUR
  • 100 ug
  • 10 ug
  • 1 mg
  • 200 ug
  • 50 ug


Abnormal amygdala subregional-sensorimotor connectivity correlates with positive symptom in schizophrenia.

Altered resting-state functional connectivity (rsFC) of the amygdala has been demonstrated to be implicated in schizophrenia neuronal pathophysiology. However, whether rsFC of amygdala subregions is differentially affected in schizophrenia remains unclear.

This study compared the functional networks of each amygdala subdivision between healthy controls (HC) and patients with first-episode schizophrenia (FES). In total, 47 HC and 78 patients with FES underwent resting-state functional magnetic resonance imaging. The amygdala was divided into the following three subregions using the Juelich histological atlas: basolateral amygdala (BLA), centromedial amygdala (CMA), and superficial amygdala (SFA). The rsFC of the three amygdala subdivisions was computed and compared between the two groups. Significantly increased rsFC of the right CMA with the right postcentral gyrus and decreased rsFC of the right BLA with the left precentral gyrus were observed in the FES group compared with the HC group. Notably, the right BLA-left precentral gyrus connectivity was negatively correlated with positive symptoms and conceptual disorganization in patients with FES.

In conclusion, this study found that patients with FES had abnormal functional connectivity in the amygdala subregions, and the altered rsFC was associated with positive symptoms. The present findings demonstrate the disruptive rsFC patterns of amygdala subregional-sensorimotor networks in FES and may provide new insights into the neuronal pathophysiology of FES.
Time courses of HMGB1 and other inflammatory markers after generalized convulsive seizures.

Neuroinflammation and disruption of blood brain barrier (BBB) are important players in epileptogenesis, ictogenesis and pharmacoresistance.

In this context, we investigated blood levels of HMGB1 and other inflammatory and BBB markers after generalized and focal to bilateral tonic-clonic seizures in serum, summarized under the term generalized convulsive seizures (GCS).We included consenting adults who were admitted to the epilepsy monitoring unit. Blood samples were drawn at baseline and immediately after a GCS as well as after 2, 6 and 24 h. We measu

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