Neuronal

The protective effect of metformin on mitochondrial dysfunction and endoplasmic reticulum stress in diabetic mice brain.

Diabetes is a metabolic disorder associated with mitochondrial (mt) dysfunction and oxidative stress. The molecular mechanisms involved in diabetes-associated neurological complications remain elusive. This study aims to investigate the protective effect of metformin (MF) on regulatory networks and integrated stress responses in brain tissue of Streptozotocin (STZ)-induced diabetic mice. STZ-induced diabetic mice were treated with MF (20 mg/kg BW), and whole brain tissue was harvested for further analysis. Protein carbonylation was measured as a marker of neuronal oxidative stress. Protein expression of mt chaperones, maintenance proteins, and regulators of the unfolded protein response (UPR) were measured by Western blot. Transcript levels of antioxidant enzyme GSTA4; mt biogenesis markers, ER stress regulators, and miR-132 and miR-148a were analysed using qPCR.

The results showed that MF efficiently reduced protein carbonylation and oxidation. Mt function was improved by MF-treatment through upregulation of chaperone proteins (HSP60, HSP70 and LonP1). MF elicits the UPR to attenuate ER stress through a miR-132 repression mechanism. Additionally, MF was found to elevate deacetylases- Sirt1, Sirt3; and mt biogenesis marker PGC-1α through miR-148a repression. This is the first study to demonstrate the epigenetic regulation of mt maintenance by MF in diabetic C57BL/6 mouse whole brain tissue. We thus conclude that MF, beyond its anti-hyperglycaemic role, mediates neuroprotection through epigenomic and integrated stress responses in diabetic mice.

nNOS (neuronal) Rabbit mAb

58735 SAB 100ul 339 EUR

Neuronal calcium sensor 1

AP85641 SAB 1mg 2640 EUR

Neuronal calcium sensor 1

AP85916 SAB 1mg 2640 EUR

Neuronal calcium sensor 1

AP86023 SAB 1mg 2640 EUR

Neuronal calcium sensor 1

AP86190 SAB 1mg 2640 EUR

Neuronal calcium sensor 1

AP86447 SAB 1mg 2640 EUR

Tau (Neuronal Marker), Antibody

GWB-BE5100 GenWay Biotech 7 ml Ask for price

Tau (Neuronal Marker), Antibody

GWB-C2FE50 GenWay Biotech 1 ml Ask for price

Non Neuronal Enolase antibody

10R-8640 Fitzgerald 100 ul 471.6 EUR
Description: Mouse monoclonal Non Neuronal Enolase antibody

Non Neuronal Enolase antibody

10R-8641 Fitzgerald 100 ul 471.6 EUR
Description: Mouse monoclonal Non Neuronal Enolase antibody

neuronal pentraxin 1 Peptide

43-393P ProSci 0.1 mg 405.6 EUR

neuronal pentraxin 1 Antibody

abx433029-200ul Abbexa 200 ul 460.8 EUR

Neuronal-specific septin-3

AP79069 SAB 1mg 2640 EUR

Neuronal-specific septin-3

AP87290 SAB 1mg 2640 EUR

Neuronal-specific septin-3

AP87582 SAB 1mg 2640 EUR

Neuronal-specific septin-3

AP87713 SAB 1mg 2640 EUR

Neuronal Pentraxin Ii Antibody

20-abx114085 Abbexa
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  • 150 ul
  • 50 ul

Cadherin, Neuronal (CDH2) Antibody

20-abx329244 Abbexa
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  • 100 ug
  • 50 ug

Cadherin, Neuronal (CDH2) Antibody

20-abx101717 Abbexa
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  • 100 ug
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  • 1 mg
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Cadherin, Neuronal (CDH2) Antibody

20-abx101718 Abbexa
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  • 100 ug
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Cadherin, Neuronal (CDH2) Antibody

20-abx101719 Abbexa
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  • 100 ug
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Cadherin, Neuronal (CDH2) Antibody

20-abx101720 Abbexa
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  • 100 ug
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Cadherin, Neuronal (CDH2) Antibody

20-abx101721 Abbexa
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  • 100 ug
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Cadherin, Neuronal (CDH2) Antibody

20-abx130190 Abbexa
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  • 100 ug
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Cadherin, Neuronal (CDH2) Antibody

20-abx130191 Abbexa
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  • 100 ug
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Cadherin, Neuronal (CDH2) Antibody

20-abx171504 Abbexa
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  • 1 mg
  • 200 ug

Cadherin, Neuronal (CDH2) Antibody

20-abx214339 Abbexa
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  • 100 ul
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Cadherin, Neuronal (CDH2) Antibody

20-abx125650 Abbexa
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  • 100 ul
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  • 20 ul
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Cadherin, Neuronal (CDH2) Antibody

20-abx128572 Abbexa
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  • 100 ug
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Cadherin, Neuronal (CDH2) Antibody

20-abx111293 Abbexa
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  • 150 ul
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Cadherin, Neuronal (CDH2) Antibody

abx146155-100ug Abbexa 100 ug 469.2 EUR

Cadherin, Neuronal (CDH2) Antibody

20-abx119088 Abbexa
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  • 100 ug
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Cadherin, Neuronal (CDH2) Antibody

20-abx002200 Abbexa
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  • 100 ul
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Cadherin, Neuronal (CDH2) Antibody

abx015808-100ul Abbexa 100 ul 493.2 EUR

Neuronal Specific Enolase Enzyme

20-abx073672 Abbexa
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  • 10 ug
  • 1 mg
  • 2 µg

Neuronal PAS1 Polyclonal Antibody

E20-73071 EnoGene 100ug 225 EUR
Description: Available in various conjugation types.

Neuronal PAS1 Polyclonal Antibody

ABP55411-003ml Abbkine 0.03ml 189.6 EUR
Description: A polyclonal antibody for detection of Neuronal PAS1 from Human. This Neuronal PAS1 antibody is for WB, ELISA. It is affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogenand is unconjugated. The antibody is produced in rabbit by using as an immunogen synthesized peptide derived from the C-terminal region of human Neuronal PAS1 at AA range: 420-500

Neuronal PAS1 Polyclonal Antibody

ABP55411-01ml Abbkine 0.1ml 346.8 EUR
Description: A polyclonal antibody for detection of Neuronal PAS1 from Human. This Neuronal PAS1 antibody is for WB, ELISA. It is affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogenand is unconjugated. The antibody is produced in rabbit by using as an immunogen synthesized peptide derived from the C-terminal region of human Neuronal PAS1 at AA range: 420-500

Neuronal PAS1 Polyclonal Antibody

ABP55411-02ml Abbkine 0.2ml 496.8 EUR
Description: A polyclonal antibody for detection of Neuronal PAS1 from Human. This Neuronal PAS1 antibody is for WB, ELISA. It is affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogenand is unconjugated. The antibody is produced in rabbit by using as an immunogen synthesized peptide derived from the C-terminal region of human Neuronal PAS1 at AA range: 420-500

Neuronal PAS1 Polyclonal Antibody

E44H02919 EnoGene 100ul 255 EUR
Description: Biotin-Conjugated, FITC-Conjugated , AF350 Conjugated , AF405M-Conjugated ,AF488-Conjugated, AF514-Conjugated ,AF532-Conjugated, AF555-Conjugated ,AF568-Conjugated , HRP-Conjugated, AF405S-Conjugated, AF405L-Conjugated , AF546-Conjugated, AF594-Conjugated , AF610-Conjugated, AF635-Conjugated , AF647-Conjugated , AF680-Conjugated , AF700-Conjugated , AF750-Conjugated , AF790-Conjugated , APC-Conjugated , PE-Conjugated , Cy3-Conjugated , Cy5-Conjugated , Cy5.5-Conjugated , Cy7-Conjugated Antibody

Neuronal Specific Enolase Antibody

20-abx137335 Abbexa
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  • 100 ug
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  • 5 ug

Recombinant Cadherin, Neuronal (CDH2)

4-RPB481Hu01 Cloud-Clone
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  • 100 ug
  • 10ug
  • 1 mg
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  • 50ug
  • 5 mg
Description: Recombinant Human Cadherin, Neuronal expressed in: E.coli

Recombinant Cadherin, Neuronal (CDH2)

4-RPB481Hu02 Cloud-Clone
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  • 100 ug
  • 10ug
  • 1 mg
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  • 500 ug
  • 50ug
  • 5 mg
Description: Recombinant Human Cadherin, Neuronal expressed in: E.coli

Recombinant Cadherin, Neuronal (CDH2)

4-RPB481Mu01 Cloud-Clone
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  • 100 ug
  • 10ug
  • 1 mg
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  • 50ug
  • 5 mg
Description: Recombinant Mouse Cadherin, Neuronal expressed in: E.coli

Recombinant Cadherin, Neuronal (CDH2)

4-RPB481Mu02 Cloud-Clone
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  • 100 ug
  • 10ug
  • 1 mg
  • 200 ug
  • 500 ug
  • 50ug
  • 5 mg
Description: Recombinant Mouse Cadherin, Neuronal expressed in: E.coli

Recombinant Cadherin, Neuronal (CDH2)

4-RPB481Ra01 Cloud-Clone
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  • 100 ug
  • 10ug
  • 1 mg
  • 200 ug
  • 500 ug
  • 50ug
  • 5 mg
Description: Recombinant Rat Cadherin, Neuronal expressed in: E.coli

Recombinant Cadherin, Neuronal (CDH2)

4-RPB481Ra02 Cloud-Clone
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  • 100 ug
  • 10ug
  • 1 mg
  • 200 ug
  • 500 ug
  • 50ug
  • 5 mg
Description: Recombinant Rat Cadherin, Neuronal expressed in: E.coli

Recombinant Cadherin, Neuronal (CDH2)

4-RPB481Ra03 Cloud-Clone
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  • 100 ug
  • 10ug
  • 1 mg
  • 200 ug
  • 500 ug
  • 50ug
  • 5 mg
Description: Recombinant Rat Cadherin, Neuronal expressed in: E.coli

Rat Cadherin, Neuronal ELISA kit

E01A11063 BlueGene 96T 700 EUR
Description: ELISA

Rat Cadherin, Neuronal ELISA kit

E02C0623-192T BlueGene 192 tests 1524 EUR
Description: A competitive ELISA for quantitative measurement of Rat Cadherin, Neuronal in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Rat Cadherin, Neuronal ELISA kit

E02C0623-48 BlueGene 1 plate of 48 wells 624 EUR
Description: A competitive ELISA for quantitative measurement of Rat Cadherin, Neuronal in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Rat Cadherin, Neuronal ELISA kit

E02C0623-96 BlueGene 1 plate of 96 wells 822 EUR
Description: A competitive ELISA for quantitative measurement of Rat Cadherin, Neuronal in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Dog Cadherin, Neuronal ELISA kit

E08C0623-192T BlueGene 192 tests 1524 EUR
Description: A competitive ELISA for quantitative measurement of Canine Cadherin, Neuronal in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Dog Cadherin, Neuronal ELISA kit

E08C0623-48 BlueGene 1 plate of 48 wells 624 EUR
Description: A competitive ELISA for quantitative measurement of Canine Cadherin, Neuronal in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Dog Cadherin, Neuronal ELISA kit

E08C0623-96 BlueGene 1 plate of 96 wells 822 EUR
Description: A competitive ELISA for quantitative measurement of Canine Cadherin, Neuronal in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Pig Cadherin, Neuronal ELISA kit

E07C0623-192T BlueGene 192 tests 1524 EUR
Description: A competitive ELISA for quantitative measurement of Porcine Cadherin, Neuronal in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Pig Cadherin, Neuronal ELISA kit

E07C0623-48 BlueGene 1 plate of 48 wells 624 EUR
Description: A competitive ELISA for quantitative measurement of Porcine Cadherin, Neuronal in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Pig Cadherin, Neuronal ELISA kit

E07C0623-96 BlueGene 1 plate of 96 wells 822 EUR
Description: A competitive ELISA for quantitative measurement of Porcine Cadherin, Neuronal in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Goat Cadherin, Neuronal ELISA kit

E01A45976 BlueGene 96T 700 EUR
Description: ELISA

Goat Cadherin, Neuronal ELISA kit

E06C0623-192T BlueGene 192 tests 1524 EUR
Description: A competitive ELISA for quantitative measurement of Goat Cadherin, Neuronal in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Goat Cadherin, Neuronal ELISA kit

E06C0623-48 BlueGene 1 plate of 48 wells 624 EUR
Description: A competitive ELISA for quantitative measurement of Goat Cadherin, Neuronal in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Goat Cadherin, Neuronal ELISA kit

E06C0623-96 BlueGene 1 plate of 96 wells 822 EUR
Description: A competitive ELISA for quantitative measurement of Goat Cadherin, Neuronal in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Sheep Cadherin, Neuronal ELISA kit

E01A98270 BlueGene 96T 700 EUR
Description: ELISA

Human Cadherin, Neuronal ELISA kit

E01C0623-192T BlueGene 192 tests 1524 EUR
Description: A competitive ELISA for quantitative measurement of Human Cadherin, Neuronal in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.


Abnormal amygdala subregional-sensorimotor connectivity correlates with positive symptom in schizophrenia.

Altered resting-state functional connectivity (rsFC) of the amygdala has been demonstrated to be implicated in schizophrenia neuronal pathophysiology. However, whether rsFC of amygdala subregions is differentially affected in schizophrenia remains unclear.

This study compared the functional networks of each amygdala subdivision between healthy controls (HC) and patients with first-episode schizophrenia (FES). In total, 47 HC and 78 patients with FES underwent resting-state functional magnetic resonance imaging. The amygdala was divided into the following three subregions using the Juelich histological atlas: basolateral amygdala (BLA), centromedial amygdala (CMA), and superficial amygdala (SFA). The rsFC of the three amygdala subdivisions was computed and compared between the two groups. Significantly increased rsFC of the right CMA with the right postcentral gyrus and decreased rsFC of the right BLA with the left precentral gyrus were observed in the FES group compared with the HC group. Notably, the right BLA-left precentral gyrus connectivity was negatively correlated with positive symptoms and conceptual disorganization in patients with FES.

In conclusion, this study found that patients with FES had abnormal functional connectivity in the amygdala subregions, and the altered rsFC was associated with positive symptoms. The present findings demonstrate the disruptive rsFC patterns of amygdala subregional-sensorimotor networks in FES and may provide new insights into the neuronal pathophysiology of FES.
Time courses of HMGB1 and other inflammatory markers after generalized convulsive seizures.

Neuroinflammation and disruption of blood brain barrier (BBB) are important players in epileptogenesis, ictogenesis and pharmacoresistance.

In this context, we investigated blood levels of HMGB1 and other inflammatory and BBB markers after generalized and focal to bilateral tonic-clonic seizures in serum, summarized under the term generalized convulsive seizures (GCS).We included consenting adults who were admitted to the epilepsy monitoring unit. Blood samples were drawn at baseline and immediately after a GCS as well as after 2, 6 and 24 h. We measu

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