Neuronal

The protective effect of metformin on mitochondrial dysfunction and endoplasmic reticulum stress in diabetic mice brain.

Diabetes is a metabolic disorder associated with mitochondrial (mt) dysfunction and oxidative stress. The molecular mechanisms involved in diabetes-associated neurological complications remain elusive. This study aims to investigate the protective effect of metformin (MF) on regulatory networks and integrated stress responses in brain tissue of Streptozotocin (STZ)-induced diabetic mice. STZ-induced diabetic mice were treated with MF (20 mg/kg BW), and whole brain tissue was harvested for further analysis. Protein carbonylation was measured as a marker of neuronal oxidative stress. Protein expression of mt chaperones, maintenance proteins, and regulators of the unfolded protein response (UPR) were measured by Western blot. Transcript levels of antioxidant enzyme GSTA4; mt biogenesis markers, ER stress regulators, and miR-132 and miR-148a were analysed using qPCR.

The results showed that MF efficiently reduced protein carbonylation and oxidation. Mt function was improved by MF-treatment through upregulation of chaperone proteins (HSP60, HSP70 and LonP1). MF elicits the UPR to attenuate ER stress through a miR-132 repression mechanism. Additionally, MF was found to elevate deacetylases- Sirt1, Sirt3; and mt biogenesis marker PGC-1α through miR-148a repression. This is the first study to demonstrate the epigenetic regulation of mt maintenance by MF in diabetic C57BL/6 mouse whole brain tissue. We thus conclude that MF, beyond its anti-hyperglycaemic role, mediates neuroprotection through epigenomic and integrated stress responses in diabetic mice.

Cadherin, Neuronal (CDH2) Antibody

20-abx329244
  • EUR 314.00
  • EUR 244.00
  • 100 ug
  • 50 ug
  • Shipped within 5-10 working days.
  • neuronal pentraxin 1 Antibody

    abx433029-200ul 200 ul
    EUR 384.00
  • Shipped within 1-3 working days.
  • Neuronal PAS1 Polyclonal Antibody

    ABP55411-003ml 0.03ml
    EUR 158.00
  • Immunogen information: Synthesized peptide derived from the C-terminal region of human Neuronal PAS1 at AA range: 420-500
  • Applications tips:
  • Description: A polyclonal antibody for detection of Neuronal PAS1 from Human. This Neuronal PAS1 antibody is for WB, ELISA. It is affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogenand is unconjugated. The antibody is produced in rabbit by using as an immunogen synthesized peptide derived from the C-terminal region of human Neuronal PAS1 at AA range: 420-500

    Neuronal PAS1 Polyclonal Antibody

    ABP55411-01ml 0.1ml
    EUR 289.00
  • Immunogen information: Synthesized peptide derived from the C-terminal region of human Neuronal PAS1 at AA range: 420-500
  • Applications tips:
  • Description: A polyclonal antibody for detection of Neuronal PAS1 from Human. This Neuronal PAS1 antibody is for WB, ELISA. It is affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogenand is unconjugated. The antibody is produced in rabbit by using as an immunogen synthesized peptide derived from the C-terminal region of human Neuronal PAS1 at AA range: 420-500

    Neuronal PAS1 Polyclonal Antibody

    ABP55411-02ml 0.2ml
    EUR 414.00
  • Immunogen information: Synthesized peptide derived from the C-terminal region of human Neuronal PAS1 at AA range: 420-500
  • Applications tips:
  • Description: A polyclonal antibody for detection of Neuronal PAS1 from Human. This Neuronal PAS1 antibody is for WB, ELISA. It is affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogenand is unconjugated. The antibody is produced in rabbit by using as an immunogen synthesized peptide derived from the C-terminal region of human Neuronal PAS1 at AA range: 420-500

    Cadherin, Neuronal (CDH2) Antibody

    abx015808-100ul 100 ul
    EUR 411.00
  • Shipped within 5-10 working days.
  • Non Neuronal Enolase antibody

    10R-8640 100 ul
    EUR 393.00
    Description: Mouse monoclonal Non Neuronal Enolase antibody

    Non Neuronal Enolase antibody

    10R-8641 100 ul
    EUR 393.00
    Description: Mouse monoclonal Non Neuronal Enolase antibody

    Non-Neuronal Enolase Antibody

    abx020643-1mg 1 mg
    EUR 815.00
  • Shipped within 5-10 working days.
  • Cadherin, Neuronal (CDH2) Antibody

    20-abx002200
    • EUR 411.00
    • EUR 592.00
    • EUR 182.00
    • EUR 314.00
    • 100 ul
    • 200 ul
    • 20 ul
    • 50 ul
  • Shipped within 5-10 working days.
  • Cadherin, Neuronal (CDH2) Antibody

    20-abx125650
    • EUR 411.00
    • EUR 592.00
    • EUR 182.00
    • EUR 314.00
    • 100 ul
    • 200 ul
    • 20 ul
    • 50 ul
  • Shipped within 5-10 working days.
  • Cadherin, Neuronal (CDH2) Antibody

    20-abx130190
    • EUR 439.00
    • EUR 133.00
    • EUR 1247.00
    • EUR 592.00
    • EUR 328.00
    • 100 ug
    • 10 ug
    • 1 mg
    • 200 ug
    • 50 ug
  • Shipped within 5-7 working days.
  • Cadherin, Neuronal (CDH2) Antibody

    20-abx130191
    • EUR 439.00
    • EUR 133.00
    • EUR 1247.00
    • EUR 592.00
    • EUR 328.00
    • 100 ug
    • 10 ug
    • 1 mg
    • 200 ug
    • 50 ug
  • Shipped within 5-7 working days.
  • Cadherin, Neuronal (CDH2) Antibody

    20-abx128572
    • EUR 411.00
    • EUR 133.00
    • EUR 1149.00
    • EUR 565.00
    • EUR 314.00
    • 100 ug
    • 10 ug
    • 1 mg
    • 200 ug
    • 50 ug
  • Shipped within 5-7 working days.
  • Cadherin, Neuronal (CDH2) Antibody

    20-abx101717
    • EUR 411.00
    • EUR 133.00
    • EUR 1149.00
    • EUR 565.00
    • EUR 314.00
    • 100 ug
    • 10 ug
    • 1 mg
    • 200 ug
    • 50 ug
  • Shipped within 5-7 working days.
  • Cadherin, Neuronal (CDH2) Antibody

    20-abx101718
    • EUR 425.00
    • EUR 133.00
    • EUR 1177.00
    • EUR 578.00
    • EUR 328.00
    • 100 ug
    • 10 ug
    • 1 mg
    • 200 ug
    • 50 ug
  • Shipped within 5-7 working days.
  • Cadherin, Neuronal (CDH2) Antibody

    20-abx101719
    • EUR 425.00
    • EUR 133.00
    • EUR 1177.00
    • EUR 578.00
    • EUR 328.00
    • 100 ug
    • 10 ug
    • 1 mg
    • 200 ug
    • 50 ug
  • Shipped within 5-7 working days.
  • Cadherin, Neuronal (CDH2) Antibody

    20-abx101720
    • EUR 425.00
    • EUR 133.00
    • EUR 1177.00
    • EUR 578.00
    • EUR 328.00
    • 100 ug
    • 10 ug
    • 1 mg
    • 200 ug
    • 50 ug
  • Shipped within 5-15 working days.
  • Cadherin, Neuronal (CDH2) Antibody

    20-abx101721
    • EUR 439.00
    • EUR 133.00
    • EUR 1247.00
    • EUR 592.00
    • EUR 328.00
    • 100 ug
    • 10 ug
    • 1 mg
    • 200 ug
    • 50 ug
  • Shipped within 5-7 working days.
  • Neuronal Specific Enolase (Recombinant)

    20-abx073283
    • EUR 3418.00
    • EUR 328.00
    • EUR 230.00
    • 1 mg
    • 25 ug
    • 5 ug
  • Shipped within 5-10 working days.
  • Neuronal Specific Enolase Enzyme

    20-abx073672
    • EUR 328.00
    • EUR 6341.00
    • EUR 230.00
    • 10 ug
    • 1 mg
    • 2 µg
  • Shipped within 5-10 working days.
  • Cadherin, Neuronal (CDH2) Antibody

    abx146155-100ug 100 ug
    EUR 391.00
  • Shipped within 5-10 working days.
  • Neuronal Specific Enolase Antibody

    20-abx137335
    • EUR 704.00
    • EUR 328.00
    • EUR 230.00
    • 100 ug
    • 20 ug
    • 5 ug
  • Shipped within 5-10 working days.
  • Cadherin, Neuronal (CDH2) Antibody

    20-abx171504
    • EUR 815.00
    • EUR 425.00
    • 1 mg
    • 200 ug
  • Please enquire.
  • Neuronal Pentraxin Ii Antibody

    20-abx114085
    • EUR 732.00
    • EUR 398.00
    • 150 ul
    • 50 ul
  • Shipped within 5-10 working days.
  • Cadherin, Neuronal (CDH2) Antibody

    20-abx119088
    • EUR 314.00
    • EUR 98.00
    • EUR 398.00
    • EUR 495.00
    • 100 ug
    • 10 ug
    • 200 ug
    • 300 µg
  • Shipped within 5-10 working days.
  • Cadherin, Neuronal (CDH2) Antibody

    20-abx111293
    • EUR 732.00
    • EUR 398.00
    • 150 ul
    • 50 ul
  • Shipped within 5-10 working days.
  • Neuronal PAS1 Polyclonal Antibody

    ES6410-100ul 100ul
    EUR 279.00
    Description: A Rabbit Polyclonal antibody against Neuronal PAS1 from Human. This antibody is tested and validated for WB, ELISA, WB, ELISA

    Neuronal PAS1 Polyclonal Antibody

    ES6410-50ul 50ul
    EUR 207.00
    Description: A Rabbit Polyclonal antibody against Neuronal PAS1 from Human. This antibody is tested and validated for WB, ELISA, WB, ELISA

    DiscoveryProbe? Neuronal Signaling Library

    L1026-.1 100 uL/well(10 mM solution)
    EUR 4968.00

    DiscoveryProbe? Neuronal Signaling Library

    L1026-.25 250 uL/well(10 mM solution)
    EUR 8866.00

    DiscoveryProbe? Neuronal Signaling Library

    L1026-5 5 mg/well
    EUR 11534.00

    Recombinant Cadherin, Neuronal (CDH2)

    4-RPB481Hu01
    • EUR 467.36
    • EUR 228.00
    • EUR 1477.60
    • EUR 559.20
    • EUR 1018.40
    • EUR 376.00
    • EUR 3544.00
    • 100 ug
    • 10ug
    • 1 mg
    • 200 ug
    • 500 ug
    • 50ug
    • 5 mg
  • Uniprot ID: P19022
  • Buffer composition: PBS, pH 7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
  • Form: Freeze-dried powder
  • Predicted Molecular Mass (KD): 27.4kDa
  • Isoelectric Point: Inquire
  • Description: Recombinant Human Cadherin, Neuronal expressed in: E.coli

    Recombinant Cadherin, Neuronal (CDH2)

    4-RPB481Hu02
    • EUR 467.36
    • EUR 228.00
    • EUR 1477.60
    • EUR 559.20
    • EUR 1018.40
    • EUR 376.00
    • EUR 3544.00
    • 100 ug
    • 10ug
    • 1 mg
    • 200 ug
    • 500 ug
    • 50ug
    • 5 mg
  • Uniprot ID: P19022
  • Buffer composition: PBS, pH 7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
  • Form: Freeze-dried powder
  • Predicted Molecular Mass (KD): 12.6kDa
  • Isoelectric Point: Inquire
  • Description: Recombinant Human Cadherin, Neuronal expressed in: E.coli

    Recombinant Cadherin, Neuronal (CDH2)

    4-RPB481Mu01
    • EUR 472.74
    • EUR 229.00
    • EUR 1497.76
    • EUR 565.92
    • EUR 1031.84
    • EUR 379.00
    • EUR 3594.40
    • 100 ug
    • 10ug
    • 1 mg
    • 200 ug
    • 500 ug
    • 50ug
    • 5 mg
  • Uniprot ID: P15116
  • Buffer composition: PBS, pH 7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
  • Form: Freeze-dried powder
  • Predicted Molecular Mass (KD): 23.8kDa
  • Isoelectric Point: Inquire
  • Description: Recombinant Mouse Cadherin, Neuronal expressed in: E.coli

    Recombinant Cadherin, Neuronal (CDH2)

    4-RPB481Mu02
    • EUR 472.74
    • EUR 229.00
    • EUR 1497.76
    • EUR 565.92
    • EUR 1031.84
    • EUR 379.00
    • EUR 3594.40
    • 100 ug
    • 10ug
    • 1 mg
    • 200 ug
    • 500 ug
    • 50ug
    • 5 mg
  • Uniprot ID: P15116
  • Buffer composition: PBS, pH 7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
  • Form: Freeze-dried powder
  • Predicted Molecular Mass (KD): 21.3kDa
  • Isoelectric Point: Inquire
  • Description: Recombinant Mouse Cadherin, Neuronal expressed in: E.coli

    Recombinant Cadherin, Neuronal (CDH2)

    4-RPB481Ra01
    • EUR 503.20
    • EUR 238.00
    • EUR 1612.00
    • EUR 604.00
    • EUR 1108.00
    • EUR 400.00
    • EUR 3880.00
    • 100 ug
    • 10ug
    • 1 mg
    • 200 ug
    • 500 ug
    • 50ug
    • 5 mg
  • Uniprot ID: Q9Z1Y3
  • Buffer composition: PBS, pH 7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
  • Form: Freeze-dried powder
  • Predicted Molecular Mass (KD): 14.6kDa
  • Isoelectric Point: Inquire
  • Description: Recombinant Rat Cadherin, Neuronal expressed in: E.coli

    Recombinant Cadherin, Neuronal (CDH2)

    4-RPB481Ra02
    • EUR 503.20
    • EUR 238.00
    • EUR 1612.00
    • EUR 604.00
    • EUR 1108.00
    • EUR 400.00
    • EUR 3880.00
    • 100 ug
    • 10ug
    • 1 mg
    • 200 ug
    • 500 ug
    • 50ug
    • 5 mg
  • Uniprot ID: Q9Z1Y3
  • Buffer composition: PBS, pH 7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
  • Form: Freeze-dried powder
  • Predicted Molecular Mass (KD): 15.0kDa
  • Isoelectric Point: Inquire
  • Description: Recombinant Rat Cadherin, Neuronal expressed in: E.coli

    Recombinant Cadherin, Neuronal (CDH2)

    4-RPB481Ra03
    • EUR 503.20
    • EUR 238.00
    • EUR 1612.00
    • EUR 604.00
    • EUR 1108.00
    • EUR 400.00
    • EUR 3880.00
    • 100 ug
    • 10ug
    • 1 mg
    • 200 ug
    • 500 ug
    • 50ug
    • 5 mg
  • Uniprot ID: Q9Z1Y3
  • Buffer composition: PBS, pH 7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
  • Form: Freeze-dried powder
  • Predicted Molecular Mass (KD): 16.3kDa
  • Isoelectric Point: Inquire
  • Description: Recombinant Rat Cadherin, Neuronal expressed in: E.coli

    Anti-Neuronal PAS1 antibody

    STJ94436 200 µl
    EUR 197.00
    Description: Rabbit polyclonal to Neuronal PAS1.

    Neuronal Differentiation 1 (NEUROD1) Antibody

    abx235674-100ug 100 ug
    EUR 481.00
  • Shipped within 5-12 working days.
  • Neuronal Differentiation 4 (NEUROD4) Antibody

    abx235675-100ug 100 ug
    EUR 481.00
  • Shipped within 5-12 working days.
  • Neuronal Pentraxin-1 (NPTX1) Antibody

    abx235827-100ug 100 ug
    EUR 509.00
  • Shipped within 5-12 working days.
  • Neuronal Pentraxin-2 (NPTX2) Antibody

    abx235828-100ug 100 ug
    EUR 481.00
  • Shipped within 5-12 working days.
  • Cadherin, Neuronal (CDH2) Antibody (Biotin)

    20-abx272144
    • EUR 439.00
    • EUR 244.00
    • EUR 1261.00
    • EUR 606.00
    • EUR 328.00
    • 100 ug
    • 10 ug
    • 1 mg
    • 200 ug
    • 50 ug
  • Shipped within 5-15 working days.
  • Cadherin, Neuronal (CDH2) Antibody (Biotin)

    20-abx272989
    • EUR 453.00
    • EUR 244.00
    • EUR 1288.00
    • EUR 620.00
    • EUR 342.00
    • 100 ug
    • 10 ug
    • 1 mg
    • 200 ug
    • 50 ug
  • Shipped within 5-15 working days.
  • Cadherin, Neuronal (CDH2) Antibody (Biotin)

    20-abx273396
    • EUR 481.00
    • EUR 244.00
    • EUR 1414.00
    • EUR 662.00
    • EUR 356.00
    • 100 ug
    • 10 ug
    • 1 mg
    • 200 ug
    • 50 ug
  • Shipped within 5-15 working days.
  • Neuronal Differentiation 1 (NEUROD1) Antibody

    abx331669-100ul 100 ul
    EUR 425.00
  • Shipped within 5-10 working days.
  • Neuronal Differentiation 2 (NEUROD2) Antibody

    abx332685-100ul 100 ul
    EUR 425.00
  • Shipped within 5-10 working days.
  • Neuronal Pentraxin I (NPTX1) Antibody

    20-abx333885
    • EUR 411.00
    • EUR 1845.00
    • EUR 599.00
    • EUR 182.00
    • EUR 300.00
    • 100 ug
    • 1 mg
    • 200 ug
    • 20 ug
    • 50 ug
  • Shipped within 5-10 working days.
  • Non-Neuronal Enolase (NNE) Antibody

    abx411517-1ml 1 ml
    EUR 439.00
  • Shipped within 1 week.
  • Neuronal Differentiation 2 (NEUROD2) Antibody

    abx433021-200ul 200 ul
    EUR 286.00
  • Shipped within 1-3 working days.
  • Neuronal Differentiation 2 (NEUROD2) Antibody

    abx433022-200ul 200 ul
    EUR 286.00
  • Shipped within 1-3 working days.
  • Neuronal Differentiation 1 (NEUROD1) Antibody

    20-abx327939
    • EUR 314.00
    • EUR 244.00
    • 100 ug
    • 50 ug
  • Shipped within 5-10 working days.
  • Neuronal Differentiation 2 (NEUROD2) Antibody

    20-abx328393
    • EUR 314.00
    • EUR 244.00
    • 100 ug
    • 50 ug
  • Shipped within 5-10 working days.
  • Neuronal Differentiation 1 (NEUROD1) Antibody

    20-abx301105
    • EUR 411.00
    • EUR 1845.00
    • EUR 599.00
    • EUR 182.00
    • EUR 300.00
    • 100 ug
    • 1 mg
    • 200 ug
    • 20 ug
    • 50 ug
  • Shipped within 5-10 working days.
  • Neuronal Pentraxin I (NPTX1) Antibody

    20-abx241691
    • EUR 411.00
    • EUR 300.00
    • 100 ul
    • 50 ul
  • Shipped within 5-10 working days.
  • Neuronal Pentraxin I (NPTX1) Antibody

    20-abx241692
    • EUR 411.00
    • EUR 300.00
    • 100 ul
    • 50 ul
  • Shipped within 5-10 working days.
  • Anti-nNOS (neuronal)/NOS1 Antibody

    A01070 100ug/vial
    EUR 294.00

    Recombinant Human Neuronal Specific Enolase

    7-02716 5µg EUR 0.00

    Recombinant Human Neuronal Specific Enolase

    7-02717 25µg EUR 0.00

    Recombinant Human Neuronal Specific Enolase

    7-02718 1mg EUR 0.00

    Neuronal Pentraxin I (NP1) Antibody

    abx033288-400ul 400 ul
    EUR 523.00
  • Shipped within 5-10 working days.
  • Neuronal Pentraxin I (NP1) Antibody

    abx033288-80l 80 µl
    EUR 286.00
  • Shipped within 5-10 working days.

  • Abnormal amygdala subregional-sensorimotor connectivity correlates with positive symptom in schizophrenia.

    Altered resting-state functional connectivity (rsFC) of the amygdala has been demonstrated to be implicated in schizophrenia neuronal pathophysiology. However, whether rsFC of amygdala subregions is differentially affected in schizophrenia remains unclear.

    This study compared the functional networks of each amygdala subdivision between healthy controls (HC) and patients with first-episode schizophrenia (FES). In total, 47 HC and 78 patients with FES underwent resting-state functional magnetic resonance imaging. The amygdala was divided into the following three subregions using the Juelich histological atlas: basolateral amygdala (BLA), centromedial amygdala (CMA), and superficial amygdala (SFA). The rsFC of the three amygdala subdivisions was computed and compared between the two groups. Significantly increased rsFC of the right CMA with the right postcentral gyrus and decreased rsFC of the right BLA with the left precentral gyrus were observed in the FES group compared with the HC group. Notably, the right BLA-left precentral gyrus connectivity was negatively correlated with positive symptoms and conceptual disorganization in patients with FES.

    In conclusion, this study found that patients with FES had abnormal functional connectivity in the amygdala subregions, and the altered rsFC was associated with positive symptoms. The present findings demonstrate the disruptive rsFC patterns of amygdala subregional-sensorimotor networks in FES and may provide new insights into the neuronal pathophysiology of FES.
    Time courses of HMGB1 and other inflammatory markers after generalized convulsive seizures.

    Neuroinflammation and disruption of blood brain barrier (BBB) are important players in epileptogenesis, ictogenesis and pharmacoresistance.

    In this context, we investigated blood levels of HMGB1 and other inflammatory and BBB markers after generalized and focal to bilateral tonic-clonic seizures in serum, summarized under the term generalized convulsive seizures (GCS).We included consenting adults who were admitted to the epilepsy monitoring unit. Blood samples were drawn at baseline and immediately after a GCS as well as after 2, 6 and 24 h. We measu