Neuromedin

Neuromedin U (NMU) regulates osteoblast differentiation and activity.

Osteoporosis is a disease of low bone mass that places individuals at enhanced risk for fracture, disability, and death. Osteoporosis rates are expected to rise significantly in the coming decades yet there are limited pharmacological treatment options, particularly for long-term management of this chronic condition.

The drug development pipeline is relatively bereft of new strategies, causing an urgent and unmet need for developing new strategies and targets for treating osteoporosis. Here, we examine a lesser-studied bone remodeling pathway, Neuromedin U (NMU), which is expressed in the bone microenvironment along with its cognate receptors NMU receptor 1 (NMUR1) and 2 (NMUR2). We independently corroborate a prior report that global loss of NMU expression leads to high bone mass and test the hypothesis that NMU negatively regulates osteoblast differentiation. Consistent with this, in vitro studies reveal NMU represses osteoblastic differentiation of osteogenic precursors but, in contrast, promotes osteoblastic marker expression, proliferation and activity of osteoblast-like cells. Phospho-profiling arrays were used to detail differential signaling outcomes that may underlie the opposite responses of these cell types.

Collectively, our findings indicate that NMU exerts cell-type-specific responses to regulate osteoblast differentiation and activity.


CAPA neuropeptides and their receptor form an anti-diuretic hormone signaling system in the human disease vector, Aedes aegypti.

Insect CAPA neuropeptides are homologs of mammalian neuromedin U and are known to influence ion and water balance by regulating the activity of the Malpighian ‘renal’ tubules (MTs). Several diuretic hormones are known to increase primary fluid and ion secretion by insect MTs and, in adult female mosquitoes, a calcitonin-related peptide (DH31) called mosquito natriuretic peptide, increases sodium secretion to compensate for the excess salt load acquired during blood-feeding. An endogenous mosquito anti-diuretic hormone was recently described, having potent inhibitory activity against select diuretic hormones, including DH31.

Herein, we functionally deorphanized, both in vitro and in vivo, a mosquito anti-diuretic hormone receptor (AedaeADHr) with expression analysis indicating highest enrichment in the MTs where it is localized within principal cells. Characterization using a heterologous in vitro system demonstrated the receptor was highly sensitive to mosquito CAPA neuropeptides while in vivo, AedaeADHr knockdown abolished CAPA-induced anti-diuretic control of DH31-stimulated MTs.

CAPA neuropeptides are produced within a pair of neurosecretory cells in each of the abdominal ganglia, whose axonal projections innervate the abdominal neurohaemal organs, where these neurohormones are released into circulation. Lastly, pharmacological inhibition of nitric oxide synthase (NOS) and protein kinase G (PKG) signaling eliminated anti-diuretic activity of CAPA, highlighting the role of the second messenger cGMP and NOS/PKG in this anti-diuretic signaling pathway.


What is the prognostic value of neuromedin U in patients with hepatocellular carcinoma?

Neuromedin U (NMU) is a neuropeptide belonging to the neuromedin family. Recently, significant associations between NMU and several cancers have been reported. However, no studies have examined the association between NMU and hepatocellular carcinoma (HCC).

The purpose of this study was to examine the role of NMU in HCC.

An enzyme-linked immunosorbent assay was used to measure the level of NMU protein in the sera of patients with hepatic hemangioma and HCC. NMU and cytokine mRNA expression was assessed in HCC samples via RT-qPCR.

Neuromedin B

4020211.0025 Bachem 25 mg 1198.79 EUR

Neuromedin C

GWB-38F200 GenWay Biotech 1 mg Ask for price

Neuromedin N

5-01602 CHI Scientific 4 x 5mg Ask for price

Neuromedin N

GWB-B64CEA GenWay Biotech 1 mg Ask for price

Neuromedin B

H-3280.0001 Bachem 1.0mg 151.2 EUR
Description: Sum Formula: C52H73N15O12S; CAS# [87096-84-2] net

Neuromedin B

H-3280.0005 Bachem 5.0mg 501.6 EUR
Description: Sum Formula: C52H73N15O12S; CAS# [87096-84-2] net

Neuromedin B

H-3280.0025 Bachem 25.0mg 1893.6 EUR
Description: Sum Formula: C52H73N15O12S; CAS# [87096-84-2] net

Neuromedin N

H-4150.0005 Bachem 5.0mg 181.2 EUR
Description: Sum Formula: C38H63N7O8; CAS# [92169-45-4] net

Neuromedin N

H-4150.0025 Bachem 25.0mg 618 EUR
Description: Sum Formula: C38H63N7O8; CAS# [92169-45-4] net

Neuromedin B

GWB-EA84E4 GenWay Biotech 1 mg Ask for price

Neuromedin N

HY-P0079 MedChemExpress 10mM/1mL 303.6 EUR

Neuromedin B

HY-P0241 MedChemExpress 10mg 870 EUR

Neuromedin B

TP1442-10mg TargetMol Chemicals 10mg Ask for price
Description: Neuromedin B

Neuromedin B

TP1442-1g TargetMol Chemicals 1g Ask for price
Description: Neuromedin B

Neuromedin B

TP1442-1mg TargetMol Chemicals 1mg Ask for price
Description: Neuromedin B

Neuromedin B

TP1442-50mg TargetMol Chemicals 50mg Ask for price
Description: Neuromedin B

Neuromedin B

TP1442-5mg TargetMol Chemicals 5mg Ask for price
Description: Neuromedin B

Neuromedin N

TP1085-10mg TargetMol Chemicals 10mg Ask for price
Description: Neuromedin N

Neuromedin N

TP1085-1g TargetMol Chemicals 1g Ask for price
Description: Neuromedin N

Neuromedin N

TP1085-1mg TargetMol Chemicals 1mg Ask for price
Description: Neuromedin N

Neuromedin N

TP1085-50mg TargetMol Chemicals 50mg Ask for price
Description: Neuromedin N

Neuromedin N

TP1085-5mg TargetMol Chemicals 5mg Ask for price
Description: Neuromedin N

Neuromedin-U

AP79194 SAB 1mg 2640 EUR

Neuromedin-U

AP85753 SAB 1mg 2640 EUR

Neuromedin-S

AP85827 SAB 1mg 2640 EUR

Neuromedin-U

AP85930 SAB 1mg 2640 EUR

Neuromedin-S

AP85992 SAB 1mg 2640 EUR

Neuromedin (B-30)

5-01596 CHI Scientific 4 x 1mg Ask for price

Neuromedin S (rat)

5-01604 CHI Scientific 4 x 1mg Ask for price

Neuromedin U, rat

5-01605 CHI Scientific 4 x 1mg Ask for price

Neuromedin U (rat)

B5231-1 ApexBio 1 mg 306 EUR
Description: Endogenous peptide regulating blood pressure

Neuromedin U (rat)

B5231-5 ApexBio 5 mg 1194 EUR
Description: Endogenous peptide regulating blood pressure

Neuromedin S (rat)

B5466-.5 ApexBio 500 µg 398 EUR
Description: endogenous neuromedin U receptor agonist

Neuromedin S (rat)

H-6228.0500 Bachem 0.5mg 544.8 EUR
Description: Sum Formula: C193H307N57O49S; CAS# [843782-19-4] net

Neuromedin S (rat)

H-6228.1000 Bachem 1.0mg 835.2 EUR
Description: Sum Formula: C193H307N57O49S; CAS# [843782-19-4] net

Neuromedin U, rat

HY-P1238 MedChemExpress 5mg 1189.2 EUR

Neuromedin S(rat)

TP1980-10mg TargetMol Chemicals 10mg Ask for price
Description: Neuromedin S(rat)

Neuromedin S(rat)

TP1980-1g TargetMol Chemicals 1g Ask for price
Description: Neuromedin S(rat)

Neuromedin S(rat)

TP1980-1mg TargetMol Chemicals 1mg Ask for price
Description: Neuromedin S(rat)

Neuromedin S(rat)

TP1980-50mg TargetMol Chemicals 50mg Ask for price
Description: Neuromedin S(rat)

Neuromedin S(rat)

TP1980-5mg TargetMol Chemicals 5mg Ask for price
Description: Neuromedin S(rat)

Neuromedin U, rat

TP1083-10mg TargetMol Chemicals 10mg Ask for price
Description: Neuromedin U, rat

Neuromedin U, rat

TP1083-1g TargetMol Chemicals 1g Ask for price
Description: Neuromedin U, rat

Neuromedin U, rat

TP1083-1mg TargetMol Chemicals 1mg Ask for price
Description: Neuromedin U, rat
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