Neuromedin

Neuromedin U (NMU) regulates osteoblast differentiation and activity.

Osteoporosis is a disease of low bone mass that places individuals at enhanced risk for fracture, disability, and death. Osteoporosis rates are expected to rise significantly in the coming decades yet there are limited pharmacological treatment options, particularly for long-term management of this chronic condition.

The drug development pipeline is relatively bereft of new strategies, causing an urgent and unmet need for developing new strategies and targets for treating osteoporosis. Here, we examine a lesser-studied bone remodeling pathway, Neuromedin U (NMU), which is expressed in the bone microenvironment along with its cognate receptors NMU receptor 1 (NMUR1) and 2 (NMUR2). We independently corroborate a prior report that global loss of NMU expression leads to high bone mass and test the hypothesis that NMU negatively regulates osteoblast differentiation. Consistent with this, in vitro studies reveal NMU represses osteoblastic differentiation of osteogenic precursors but, in contrast, promotes osteoblastic marker expression, proliferation and activity of osteoblast-like cells. Phospho-profiling arrays were used to detail differential signaling outcomes that may underlie the opposite responses of these cell types.

Collectively, our findings indicate that NMU exerts cell-type-specific responses to regulate osteoblast differentiation and activity.


CAPA neuropeptides and their receptor form an anti-diuretic hormone signaling system in the human disease vector, Aedes aegypti.

Insect CAPA neuropeptides are homologs of mammalian neuromedin U and are known to influence ion and water balance by regulating the activity of the Malpighian ‘renal’ tubules (MTs). Several diuretic hormones are known to increase primary fluid and ion secretion by insect MTs and, in adult female mosquitoes, a calcitonin-related peptide (DH31) called mosquito natriuretic peptide, increases sodium secretion to compensate for the excess salt load acquired during blood-feeding. An endogenous mosquito anti-diuretic hormone was recently described, having potent inhibitory activity against select diuretic hormones, including DH31.

Herein, we functionally deorphanized, both in vitro and in vivo, a mosquito anti-diuretic hormone receptor (AedaeADHr) with expression analysis indicating highest enrichment in the MTs where it is localized within principal cells. Characterization using a heterologous in vitro system demonstrated the receptor was highly sensitive to mosquito CAPA neuropeptides while in vivo, AedaeADHr knockdown abolished CAPA-induced anti-diuretic control of DH31-stimulated MTs.

CAPA neuropeptides are produced within a pair of neurosecretory cells in each of the abdominal ganglia, whose axonal projections innervate the abdominal neurohaemal organs, where these neurohormones are released into circulation. Lastly, pharmacological inhibition of nitric oxide synthase (NOS) and protein kinase G (PKG) signaling eliminated anti-diuretic activity of CAPA, highlighting the role of the second messenger cGMP and NOS/PKG in this anti-diuretic signaling pathway.


What is the prognostic value of neuromedin U in patients with hepatocellular carcinoma?

Neuromedin U (NMU) is a neuropeptide belonging to the neuromedin family. Recently, significant associations between NMU and several cancers have been reported. However, no studies have examined the association between NMU and hepatocellular carcinoma (HCC).

The purpose of this study was to examine the role of NMU in HCC.

An enzyme-linked immunosorbent assay was used to measure the level of NMU protein in the sera of patients with hepatic hemangioma and HCC. NMU and cytokine mRNA expression was assessed in HCC samples via RT-qPCR.

Neuromedin N

5-01602 CHI Scientific 4 x 5mg Ask for price

Neuromedin B

H-3280.0001 Bachem 1.0mg 126 EUR
Description: Sum Formula: C52H73N15O12S; CAS# [87096-84-2] net

Neuromedin B

H-3280.0005 Bachem 5.0mg 418 EUR
Description: Sum Formula: C52H73N15O12S; CAS# [87096-84-2] net

Neuromedin B

H-3280.0025 Bachem 25.0mg 1578 EUR
Description: Sum Formula: C52H73N15O12S; CAS# [87096-84-2] net

Neuromedin N

H-4150.0005 Bachem 5.0mg 151 EUR
Description: Sum Formula: C38H63N7O8; CAS# [92169-45-4] net

Neuromedin N

H-4150.0025 Bachem 25.0mg 515 EUR
Description: Sum Formula: C38H63N7O8; CAS# [92169-45-4] net

Neuromedin U, rat

HY-P1238 MedChemExpress 5mg 991 EUR

[Ser2] - Neuromedin C

5-00300 CHI Scientific 4 x 5mg Ask for price

Biotin-Neuromedin B

5-00808 CHI Scientific 4 x 5mg Ask for price

Neuromedin (B-30)

5-01596 CHI Scientific 4 x 1mg Ask for price

Neuromedin (U25), human

5-01597 CHI Scientific 4 x 1mg Ask for price

Neuromedin (U25), porcine

5-01598 CHI Scientific 4 x 1mg Ask for price

Neuromedin (U8), porcine

5-01599 CHI Scientific 4 x 5mg Ask for price

Neuromedin B, porcine

5-01600 CHI Scientific 4 x 5mg Ask for price

Neuromedin S (human)

5-01603 CHI Scientific 4 x 1mg Ask for price

Neuromedin S (rat)

5-01604 CHI Scientific 4 x 1mg Ask for price

Neuromedin U, rat

5-01605 CHI Scientific 4 x 1mg Ask for price

Neuromedin B Peptide

20-abx265473 Abbexa
  • 467.00 EUR
  • 759.00 EUR
  • 342.00 EUR
  • 10 mg
  • 25 mg
  • 5 mg

Neuromedin (U8) Peptide

20-abx265480 Abbexa
  • 411.00 EUR
  • 662.00 EUR
  • 314.00 EUR
  • 10 mg
  • 25 mg
  • 5 mg

Neuromedin N Peptide

20-abx265805 Abbexa
  • 328.00 EUR
  • 495.00 EUR
  • 272.00 EUR
  • 10 mg
  • 25 mg
  • 5 mg

Neuromedin C (porcine)

B5215-1 ApexBio 1 mg 213 EUR

Neuromedin B (porcine)

B5225-1 ApexBio 1 mg 176 EUR

Neuromedin B (porcine)

B5225-10 ApexBio 10 mg 937 EUR

Neuromedin B (porcine)

B5225-25 ApexBio 25 mg 1842 EUR

Neuromedin B (porcine)

B5225-5 ApexBio 5 mg 556 EUR

Neuromedin U (rat)

B5231-1 ApexBio 1 mg 366 EUR

Neuromedin U (rat)

B5231-5 ApexBio 5 mg 1286 EUR

Neuromedin S (rat)

B5466-.5 ApexBio 500 µg 466 EUR

Neuromedin S (rat)

H-6228.0500 Bachem 0.5mg 454 EUR
Description: Sum Formula: C193H307N57O49S; CAS# [843782-19-4] net

Neuromedin S (rat)

H-6228.1000 Bachem 1.0mg 696 EUR
Description: Sum Formula: C193H307N57O49S; CAS# [843782-19-4] net

Neuromedin S (human)

H-6232.0500 Bachem 0.5mg 454 EUR
Description: Sum Formula: C173H265N53O44; CAS# [1138204-27-9] net

Neuromedin S (human)

H-6232.1000 Bachem 1.0mg 696 EUR
Description: Sum Formula: C173H265N53O44; CAS# [1138204-27-9] net

Neuromedin U Antibody

47927-100ul SAB 100ul 252 EUR

Neuromedin U antibody

20R-NR005 Fitzgerald 50 uL 532 EUR
Description: Rabbit polyclonal Neuromedin U antibody

Neuromedin S antibody

70R-51177 Fitzgerald 100 ul 244 EUR
Description: Purified Polyclonal Neuromedin S antibody

Neuromedin B antibody

70R-51309 Fitzgerald 100 ul 244 EUR
Description: Purified Polyclonal Neuromedin B antibody

Neuromedin-S Polyclonal Antibody

ES2932-100ul ELK Biotech 100ul 279 EUR
Description: A Rabbit Polyclonal antibody against Neuromedin-S from Human. This antibody is tested and validated for WB, ELISA, IHC, WB, ELISA

Neuromedin-S Polyclonal Antibody

ES2932-50ul ELK Biotech 50ul 207 EUR
Description: A Rabbit Polyclonal antibody against Neuromedin-S from Human. This antibody is tested and validated for WB, ELISA, IHC, WB, ELISA

Neuromedin-U Polyclonal Antibody

ES2933-100ul ELK Biotech 100ul 279 EUR
Description: A Rabbit Polyclonal antibody against Neuromedin-U from Human. This antibody is tested and validated for WB, ELISA, IHC, WB, ELISA

Neuromedin-U Polyclonal Antibody

ES2933-50ul ELK Biotech 50ul 207 EUR
Description: A Rabbit Polyclonal antibody against Neuromedin-U from Human. This antibody is tested and validated for WB, ELISA, IHC, WB, ELISA

Neuromedin U (NMU) Antibody

20-abx133261 Abbexa
  • 300.00 EUR
  • 439.00 EUR
  • 189.00 EUR
  • 100 ul
  • 200 ul
  • 30 ul

Neuromedin U (NMU) Antibody

20-abx128749 Abbexa
  • 411.00 EUR
  • 133.00 EUR
  • 1149.00 EUR
  • 565.00 EUR
  • 314.00 EUR
  • 100 ug
  • 10 ug
  • 1 mg
  • 200 ug
  • 50 ug

Neuromedin S (NMS) Antibody

20-abx129537 Abbexa
  • 411.00 EUR
  • 133.00 EUR
  • 1135.00 EUR
  • 551.00 EUR
  • 314.00 EUR
  • 100 ug
  • 10 ug
  • 1 mg
  • 200 ug
  • 50 ug

Neuromedin U (NMU) Antibody

20-abx130029 Abbexa
  • 439.00 EUR
  • 133.00 EUR
  • 1247.00 EUR
  • 592.00 EUR
  • 328.00 EUR
  • 100 ug
  • 10 ug
  • 1 mg
  • 200 ug
  • 50 ug
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