Neuromedin U (NMU) regulates osteoblast differentiation and activity.

Osteoporosis is a disease of low bone mass that places individuals at enhanced risk for fracture, disability, and death. Osteoporosis rates are expected to rise significantly in the coming decades yet there are limited pharmacological treatment options, particularly for long-term management of this chronic condition.

The drug development pipeline is relatively bereft of new strategies, causing an urgent and unmet need for developing new strategies and targets for treating osteoporosis. Here, we examine a lesser-studied bone remodeling pathway, Neuromedin U (NMU), which is expressed in the bone microenvironment along with its cognate receptors NMU receptor 1 (NMUR1) and 2 (NMUR2). We independently corroborate a prior report that global loss of NMU expression leads to high bone mass and test the hypothesis that NMU negatively regulates osteoblast differentiation. Consistent with this, in vitro studies reveal NMU represses osteoblastic differentiation of osteogenic precursors but, in contrast, promotes osteoblastic marker expression, proliferation and activity of osteoblast-like cells. Phospho-profiling arrays were used to detail differential signaling outcomes that may underlie the opposite responses of these cell types.

Collectively, our findings indicate that NMU exerts cell-type-specific responses to regulate osteoblast differentiation and activity.

CAPA neuropeptides and their receptor form an anti-diuretic hormone signaling system in the human disease vector, Aedes aegypti.

Insect CAPA neuropeptides are homologs of mammalian neuromedin U and are known to influence ion and water balance by regulating the activity of the Malpighian ‘renal’ tubules (MTs). Several diuretic hormones are known to increase primary fluid and ion secretion by insect MTs and, in adult female mosquitoes, a calcitonin-related peptide (DH31) called mosquito natriuretic peptide, increases sodium secretion to compensate for the excess salt load acquired during blood-feeding. An endogenous mosquito anti-diuretic hormone was recently described, having potent inhibitory activity against select diuretic hormones, including DH31.

Herein, we functionally deorphanized, both in vitro and in vivo, a mosquito anti-diuretic hormone receptor (AedaeADHr) with expression analysis indicating highest enrichment in the MTs where it is localized within principal cells. Characterization using a heterologous in vitro system demonstrated the receptor was highly sensitive to mosquito CAPA neuropeptides while in vivo, AedaeADHr knockdown abolished CAPA-induced anti-diuretic control of DH31-stimulated MTs.

CAPA neuropeptides are produced within a pair of neurosecretory cells in each of the abdominal ganglia, whose axonal projections innervate the abdominal neurohaemal organs, where these neurohormones are released into circulation. Lastly, pharmacological inhibition of nitric oxide synthase (NOS) and protein kinase G (PKG) signaling eliminated anti-diuretic activity of CAPA, highlighting the role of the second messenger cGMP and NOS/PKG in this anti-diuretic signaling pathway.

What is the prognostic value of neuromedin U in patients with hepatocellular carcinoma?

Neuromedin U (NMU) is a neuropeptide belonging to the neuromedin family. Recently, significant associations between NMU and several cancers have been reported. However, no studies have examined the association between NMU and hepatocellular carcinoma (HCC).

The purpose of this study was to examine the role of NMU in HCC.

An enzyme-linked immunosorbent assay was used to measure the level of NMU protein in the sera of patients with hepatic hemangioma and HCC. NMU and cytokine mRNA expression was assessed in HCC samples via RT-qPCR.

Neuromedin B
HY-P0241	MedChemExpress	10mg	870 EUR
Neuromedin N
H-4150.0005	Bachem	5.0mg	181.2 EUR
Description: Sum Formula: C38H63N7O8; CAS# [92169-45-4] net
Neuromedin N
H-4150.0025	Bachem	25.0mg	618 EUR
Description: Sum Formula: C38H63N7O8; CAS# [92169-45-4] net
Neuromedin B
H-3280.0001	Bachem	1.0mg	151.2 EUR
Description: Sum Formula: C52H73N15O12S; CAS# [87096-84-2] net
Neuromedin B
H-3280.0005	Bachem	5.0mg	501.6 EUR
Description: Sum Formula: C52H73N15O12S; CAS# [87096-84-2] net
Neuromedin B
H-3280.0025	Bachem	25.0mg	1893.6 EUR
Description: Sum Formula: C52H73N15O12S; CAS# [87096-84-2] net
Neuromedin B Antibody
DF9693	Affbiotech	200ul	420 EUR
Neuromedin S antibody
70R-51177	Fitzgerald	100 ul	292.8 EUR
Description: Purified Polyclonal Neuromedin S antibody
Neuromedin B antibody
70R-51309	Fitzgerald	100 ul	292.8 EUR
Description: Purified Polyclonal Neuromedin B antibody
Neuromedin U Antibody
47927-100ul	SAB	100ul	302.4 EUR
[Ser2] - Neuromedin C
5-00300	CHI Scientific	4 x 5mg	Ask for price
Biotin-Neuromedin B
5-00808	CHI Scientific	4 x 5mg	Ask for price
Neuromedin (B-30)
5-01596	CHI Scientific	4 x 1mg	Ask for price
Neuromedin (U25), human
5-01597	CHI Scientific	4 x 1mg	Ask for price
Neuromedin (U25), porcine
5-01598	CHI Scientific	4 x 1mg	Ask for price
Neuromedin (U8), porcine
5-01599	CHI Scientific	4 x 5mg	Ask for price
Neuromedin B, porcine
5-01600	CHI Scientific	4 x 5mg	Ask for price
Neuromedin S (human)
5-01603	CHI Scientific	4 x 1mg	Ask for price
Neuromedin S (rat)
5-01604	CHI Scientific	4 x 1mg	Ask for price
Neuromedin U, rat
5-01605	CHI Scientific	4 x 1mg	Ask for price
Neuromedin U antibody
20R-NR005	Fitzgerald	50 uL	638.4 EUR
Description: Rabbit polyclonal Neuromedin U antibody
Neuromedin B Peptide
20-abx265473	Abbexa	560.40 EUR 910.80 EUR 410.40 EUR	10 mg 25 mg 5 mg
Neuromedin (U8) Peptide
20-abx265480	Abbexa	493.20 EUR 794.40 EUR 376.80 EUR	10 mg 25 mg 5 mg
Neuromedin N Peptide
20-abx265805	Abbexa	393.60 EUR 594.00 EUR 326.40 EUR	10 mg 25 mg 5 mg
Neuromedin C (porcine)
B5215-1	ApexBio	1 mg	255.6 EUR
Neuromedin B (porcine)
B5225-1	ApexBio	1 mg	211.2 EUR
Neuromedin B (porcine)
B5225-10	ApexBio	10 mg	1124.4 EUR
Neuromedin B (porcine)
B5225-25	ApexBio	25 mg	2210.4 EUR
Neuromedin B (porcine)
B5225-5	ApexBio	5 mg	667.2 EUR
Neuromedin U (rat)
B5231-1	ApexBio	1 mg	439.2 EUR
Neuromedin U (rat)
B5231-5	ApexBio	5 mg	1543.2 EUR
Neuromedin S (rat)
B5466-.5	ApexBio	500 µg	559.2 EUR
Neuromedin U, rat
HY-P1238	MedChemExpress	5mg	1189.2 EUR
Neuromedin S (rat)
H-6228.0500	Bachem	0.5mg	544.8 EUR
Description: Sum Formula: C193H307N57O49S; CAS# [843782-19-4] net
Neuromedin S (rat)
H-6228.1000	Bachem	1.0mg	835.2 EUR
Description: Sum Formula: C193H307N57O49S; CAS# [843782-19-4] net
Neuromedin S (human)
H-6232.0500	Bachem	0.5mg	544.8 EUR
Description: Sum Formula: C173H265N53O44; CAS# [1138204-27-9] net
Neuromedin S (human)
H-6232.1000	Bachem	1.0mg	835.2 EUR
Description: Sum Formula: C173H265N53O44; CAS# [1138204-27-9] net
Neuromedin U Conjugated Antibody
C47927	SAB	100ul	476.4 EUR
anti- neuromedin B antibody
FNab05678	FN Test	100µg	606.3 EUR
Description: Antibody raised against neuromedin B
Neuromedin-S Polyclonal Antibody
ES2932-100ul	ELK Biotech	100ul	334.8 EUR
Description: A Rabbit Polyclonal antibody against Neuromedin-S from Human. This antibody is tested and validated for WB, ELISA, IHC, WB, ELISA
Neuromedin-S Polyclonal Antibody
ES2932-50ul	ELK Biotech	50ul	248.4 EUR
Description: A Rabbit Polyclonal antibody against Neuromedin-S from Human. This antibody is tested and validated for WB, ELISA, IHC, WB, ELISA
Neuromedin-U Polyclonal Antibody
ES2933-100ul	ELK Biotech	100ul	334.8 EUR
Description: A Rabbit Polyclonal antibody against Neuromedin-U from Human. This antibody is tested and validated for WB, ELISA, IHC, WB, ELISA
Neuromedin-U Polyclonal Antibody
ES2933-50ul	ELK Biotech	50ul	248.4 EUR
Description: A Rabbit Polyclonal antibody against Neuromedin-U from Human. This antibody is tested and validated for WB, ELISA, IHC, WB, ELISA
Biotin-Neuromedin S (human)
5-00809	CHI Scientific	4 x 1mg	Ask for price