Neuromedin

Neuromedin U (NMU) regulates osteoblast differentiation and activity.

Osteoporosis is a disease of low bone mass that places individuals at enhanced risk for fracture, disability, and death. Osteoporosis rates are expected to rise significantly in the coming decades yet there are limited pharmacological treatment options, particularly for long-term management of this chronic condition.

The drug development pipeline is relatively bereft of new strategies, causing an urgent and unmet need for developing new strategies and targets for treating osteoporosis. Here, we examine a lesser-studied bone remodeling pathway, Neuromedin U (NMU), which is expressed in the bone microenvironment along with its cognate receptors NMU receptor 1 (NMUR1) and 2 (NMUR2). We independently corroborate a prior report that global loss of NMU expression leads to high bone mass and test the hypothesis that NMU negatively regulates osteoblast differentiation. Consistent with this, in vitro studies reveal NMU represses osteoblastic differentiation of osteogenic precursors but, in contrast, promotes osteoblastic marker expression, proliferation and activity of osteoblast-like cells. Phospho-profiling arrays were used to detail differential signaling outcomes that may underlie the opposite responses of these cell types.

Collectively, our findings indicate that NMU exerts cell-type-specific responses to regulate osteoblast differentiation and activity.


CAPA neuropeptides and their receptor form an anti-diuretic hormone signaling system in the human disease vector, Aedes aegypti.

Insect CAPA neuropeptides are homologs of mammalian neuromedin U and are known to influence ion and water balance by regulating the activity of the Malpighian ‘renal’ tubules (MTs). Several diuretic hormones are known to increase primary fluid and ion secretion by insect MTs and, in adult female mosquitoes, a calcitonin-related peptide (DH31) called mosquito natriuretic peptide, increases sodium secretion to compensate for the excess salt load acquired during blood-feeding. An endogenous mosquito anti-diuretic hormone was recently described, having potent inhibitory activity against select diuretic hormones, including DH31.

Herein, we functionally deorphanized, both in vitro and in vivo, a mosquito anti-diuretic hormone receptor (AedaeADHr) with expression analysis indicating highest enrichment in the MTs where it is localized within principal cells. Characterization using a heterologous in vitro system demonstrated the receptor was highly sensitive to mosquito CAPA neuropeptides while in vivo, AedaeADHr knockdown abolished CAPA-induced anti-diuretic control of DH31-stimulated MTs.

CAPA neuropeptides are produced within a pair of neurosecretory cells in each of the abdominal ganglia, whose axonal projections innervate the abdominal neurohaemal organs, where these neurohormones are released into circulation. Lastly, pharmacological inhibition of nitric oxide synthase (NOS) and protein kinase G (PKG) signaling eliminated anti-diuretic activity of CAPA, highlighting the role of the second messenger cGMP and NOS/PKG in this anti-diuretic signaling pathway.


What is the prognostic value of neuromedin U in patients with hepatocellular carcinoma?

Neuromedin U (NMU) is a neuropeptide belonging to the neuromedin family. Recently, significant associations between NMU and several cancers have been reported. However, no studies have examined the association between NMU and hepatocellular carcinoma (HCC).

The purpose of this study was to examine the role of NMU in HCC.

An enzyme-linked immunosorbent assay was used to measure the level of NMU protein in the sera of patients with hepatic hemangioma and HCC. NMU and cytokine mRNA expression was assessed in HCC samples via RT-qPCR.

Neuromedin

MBS826691-5mg MyBiosource 5mg 205 EUR

Neuromedin

MBS826691-5x10mg MyBiosource 5x10mg 1110 EUR

NMB, ID (NMB, Neuromedin-B, Neuromedin-B-32)

MBS6010079-02mL MyBiosource 0.2(mL 695 EUR

NMB, ID (NMB, Neuromedin-B, Neuromedin-B-32)

MBS6010079-5x02mL MyBiosource 5x0.2mL 2975 EUR

NMB, ID (NMB, Neuromedin-B, Neuromedin-B-32) (AP)

MBS6325807-02mL MyBiosource 0.2mL 980 EUR

NMB, ID (NMB, Neuromedin-B, Neuromedin-B-32) (AP)

MBS6325807-5x02mL MyBiosource 5x0.2mL 4250 EUR

NMB, ID (NMB, Neuromedin-B, Neuromedin-B-32) (PE)

MBS6325817-02mL MyBiosource 0.2mL 980 EUR

NMB, ID (NMB, Neuromedin-B, Neuromedin-B-32) (PE)

MBS6325817-5x02mL MyBiosource 5x0.2mL 4250 EUR

NMB, ID (NMB, Neuromedin-B, Neuromedin-B-32) (APC)

MBS6325808-02mL MyBiosource 0.2mL 980 EUR

NMB, ID (NMB, Neuromedin-B, Neuromedin-B-32) (APC)

MBS6325808-5x02mL MyBiosource 5x0.2mL 4250 EUR

NMU (Neuromedin U, Neuromedin-U-25, NmU-25) (AP)

MBS6387183-01mL MyBiosource 0.1mL 920 EUR

NMU (Neuromedin U, Neuromedin-U-25, NmU-25) (AP)

MBS6387183-5x01mL MyBiosource 5x0.1mL 3990 EUR

NMU (Neuromedin U, Neuromedin-U-25, NmU-25) (PE)

MBS6387193-01mL MyBiosource 0.1mL 920 EUR

NMU (Neuromedin U, Neuromedin-U-25, NmU-25) (PE)

MBS6387193-5x01mL MyBiosource 5x0.1mL 3990 EUR

NMB, ID (NMB, Neuromedin-B, Neuromedin-B-32) (FITC)

MBS6325810-02mL MyBiosource 0.2mL 980 EUR

NMB, ID (NMB, Neuromedin-B, Neuromedin-B-32) (FITC)

MBS6325810-5x02mL MyBiosource 5x0.2mL 4250 EUR

NMU (Neuromedin U, Neuromedin-U-25, NmU-25) APC

MBS6387184-01mL MyBiosource 0.1mL 920 EUR

NMU (Neuromedin U, Neuromedin-U-25, NmU-25) APC

MBS6387184-5x01mL MyBiosource 5x0.1mL 3990 EUR

NMU (Neuromedin U, Neuromedin-U-25, NmU-25) (HRP)

MBS6387187-01mL MyBiosource 0.1mL 920 EUR

NMU (Neuromedin U, Neuromedin-U-25, NmU-25) (HRP)

MBS6387187-5x01mL MyBiosource 5x0.1mL 3990 EUR

NMU (Neuromedin U, Neuromedin-U-25, NmU-25) (FITC)

MBS6387186-01mL MyBiosource 0.1mL 920 EUR

NMU (Neuromedin U, Neuromedin-U-25, NmU-25) (FITC)

MBS6387186-5x01mL MyBiosource 5x0.1mL 3990 EUR

NMB, ID (NMB, Neuromedin-B, Neuromedin-B-32) (Biotin)

MBS6325809-02mL MyBiosource 0.2mL 980 EUR

NMB, ID (NMB, Neuromedin-B, Neuromedin-B-32) (Biotin)

MBS6325809-5x02mL MyBiosource 5x0.2mL 4250 EUR

NMU (Neuromedin U, Neuromedin-U-25, NmU-25) (Biotin)

MBS6387185-01mL MyBiosource 0.1mL 920 EUR

NMU (Neuromedin U, Neuromedin-U-25, NmU-25) (Biotin)

MBS6387185-5x01mL MyBiosource 5x0.1mL 3990 EUR

Neuromedin N

5-01602 CHI Scientific 4 x 5mg 139.23 EUR
Description: Lys-Ile-Pro-Tyr-Ile-Leu

Neuromedin B

4020211.0001 Bachem 1 mg 75.29 EUR

Neuromedin B

4020211.0005 Bachem 5 mg 299.99 EUR

Neuromedin B

4020211.0025 Bachem 25 mg 1198.79 EUR

Neuromedin N

HY-P0079 MedChemExpress 10mM/1mL 303.6 EUR

Neuromedin B

HY-P0241 MedChemExpress 10mg 870 EUR

Neuromedin B

H-3280.0001 Bachem 1.0mg 151.2 EUR
Description: Sum Formula: C52H73N15O12S; CAS# [87096-84-2] net

Neuromedin B

H-3280.0005 Bachem 5.0mg 501.6 EUR
Description: Sum Formula: C52H73N15O12S; CAS# [87096-84-2] net

Neuromedin B

H-3280.0025 Bachem 25.0mg 1893.6 EUR
Description: Sum Formula: C52H73N15O12S; CAS# [87096-84-2] net

Neuromedin N

H-4150.0005 Bachem 5.0mg 181.2 EUR
Description: Sum Formula: C38H63N7O8; CAS# [92169-45-4] net

Neuromedin N

H-4150.0025 Bachem 25.0mg 618 EUR
Description: Sum Formula: C38H63N7O8; CAS# [92169-45-4] net

Neuromedin C

GWB-38F200 GenWay Biotech 1 mg Ask for price

Neuromedin N

GWB-B64CEA GenWay Biotech 1 mg Ask for price

Neuromedin B

GWB-EA84E4 GenWay Biotech 1 mg Ask for price

Neuromedin N

MBS5763397-10mg MyBiosource 10mg 195 EUR

Neuromedin N

MBS5763397-25mg MyBiosource 25mg 310 EUR

Neuromedin N

MBS5763397-5mg MyBiosource 5mg 170 EUR

Neuromedin N

MBS5763397-5x25mg MyBiosource 5x25mg 1255 EUR
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