Description: A sandwich quantitative ELISA assay kit for detection of Human Huntingtin Associated Protein 1 (HAP1) in samples from tissue homogenates or other biological fluids.

Description: A sandwich quantitative ELISA assay kit for detection of Human Huntingtin Associated Protein 1 (HAP1) in samples from tissue homogenates or other biological fluids.

Description: A polyclonal antibody raised in Goat that recognizes and binds to Human HAP1 (Internal). This antibody is tested and proven to work in the following applications:

Description: A polyclonal antibody raised in Rabbit that recognizes and binds to Human HAP1 (Internal). This antibody is tested and proven to work in the following applications:

Description: A polyclonal antibody against HAP1. Recognizes HAP1 from Human. This antibody is Unconjugated. Tested in the following application: ELISA, IF; Recommended dilution: IF:1:50-1:200

Description: HAP1 Antibody: Huntington's disease (HD), a neurodegenerative disorder characterized by loss of striatal neurons, is caused by an expansion of a polyglutamine tract in the HD protein huntingtin. HAP1 was initially identified through a two-hybrid library screening; the binding of HAP1 to huntingtin correlated with the expansion of the polyglutamine tract. HAP1 also interacts with two cytoskeletal proteins (dynactin and pericentriolar autoantigen protein 1), suggesting that HAP1 may play a role in vesicular trafficking or organelle transport. HAP1 is also involved with the huntingtin-enhanced BDNF transport along the cellular microtubles. Attenuation of this process led to the loss of neurotrophic support and neuronal toxicity, which suggests that loss of this function might contribute to pathogenesis. Several alternatively spliced isoforms have been described for HAP1.

Description: HAP1 Antibody: Huntington's disease (HD), a neurodegenerative disorder characterized by loss of striatal neurons, is caused by an expansion of a polyglutamine tract in the HD protein huntingtin. HAP1 was initially identified through a two-hybrid library screening; the binding of HAP1 to huntingtin correlated with the expansion of the polyglutamine tract. HAP1 also interacts with two cytoskeletal proteins (dynactin and pericentriolar autoantigen protein 1), suggesting that HAP1 may play a role in vesicular trafficking or organelle transport. HAP1 is also involved with the huntingtin-enhanced BDNF transport along the cellular microtubles. Attenuation of this process led to the loss of neurotrophic support and neuronal toxicity, which suggests that loss of this function might contribute to pathogenesis. Several alternatively spliced isoforms have been described for HAP1.

Description: A polyclonal antibody raised in Goat that recognizes and binds to Human Goat Anti-HAP1 . This antibody is tested and proven to work in the following applications:

Description: A polyclonal antibody raised in Rabbit that recognizes and binds to Human HAP1 (aa639-653). This antibody is tested and proven to work in the following applications:

Description: Antibody raised against HAP1

Description: Unconjugated Rabbit polyclonal to HAP1

Description: (IN) HAP1 Peptide

Description: (CT) HAP1 (mouse) Peptide

Description: (IN) HAP1 peptide

Description: Mouse polyclonal to HAP1

Description: A polyclonal antibody against HAP1. Recognizes HAP1 from Human. This antibody is HRP conjugated. Tested in the following application: ELISA

Description: A polyclonal antibody against HAP1. Recognizes HAP1 from Human. This antibody is FITC conjugated. Tested in the following application: ELISA

Description: A polyclonal antibody against HAP1. Recognizes HAP1 from Human. This antibody is Biotin conjugated. Tested in the following application: ELISA

Description: A Rabbit polyclonal antibody against Human Huntingtin Associated Protein 1 (HAP1)

Description: A Rabbit polyclonal antibody against Mouse Huntingtin Associated Protein 1 (HAP1)

Description: A Rabbit polyclonal antibody against Rat Huntingtin Associated Protein 1 (HAP1)

Description: Recombinant protein for human HAP1

Description: A Rabbit polyclonal antibody against Human Huntingtin Associated Protein 1 (HAP1). This antibody is labeled with APC.

Description: A Rabbit polyclonal antibody against Human Huntingtin Associated Protein 1 (HAP1). This antibody is labeled with Biotin.

Description: A Rabbit polyclonal antibody against Human Huntingtin Associated Protein 1 (HAP1). This antibody is labeled with Cy3.

Description: A Rabbit polyclonal antibody against Human Huntingtin Associated Protein 1 (HAP1). This antibody is labeled with FITC.

Description: A Rabbit polyclonal antibody against Human Huntingtin Associated Protein 1 (HAP1). This antibody is labeled with HRP.

Description: A Rabbit polyclonal antibody against Human Huntingtin Associated Protein 1 (HAP1). This antibody is labeled with PE.

Description: A Rabbit polyclonal antibody against Mouse Huntingtin Associated Protein 1 (HAP1). This antibody is labeled with APC.

Description: A Rabbit polyclonal antibody against Mouse Huntingtin Associated Protein 1 (HAP1). This antibody is labeled with Biotin.

Description: A Rabbit polyclonal antibody against Mouse Huntingtin Associated Protein 1 (HAP1). This antibody is labeled with Cy3.

Description: A Rabbit polyclonal antibody against Mouse Huntingtin Associated Protein 1 (HAP1). This antibody is labeled with FITC.

Description: A Rabbit polyclonal antibody against Mouse Huntingtin Associated Protein 1 (HAP1). This antibody is labeled with HRP.

Description: A Rabbit polyclonal antibody against Mouse Huntingtin Associated Protein 1 (HAP1). This antibody is labeled with PE.

Description: A Rabbit polyclonal antibody against Rat Huntingtin Associated Protein 1 (HAP1). This antibody is labeled with APC.

Description: A Rabbit polyclonal antibody against Rat Huntingtin Associated Protein 1 (HAP1). This antibody is labeled with Biotin.

Description: A Rabbit polyclonal antibody against Rat Huntingtin Associated Protein 1 (HAP1). This antibody is labeled with Cy3.

Description: A Rabbit polyclonal antibody against Rat Huntingtin Associated Protein 1 (HAP1). This antibody is labeled with FITC.

Description: A Rabbit polyclonal antibody against Rat Huntingtin Associated Protein 1 (HAP1). This antibody is labeled with HRP.

Description: A Rabbit polyclonal antibody against Rat Huntingtin Associated Protein 1 (HAP1). This antibody is labeled with PE.

Description: Huntingtin-associated protein 1 (HAP1) is a protein which in humans is encoded by the HAP1 gene. Huntington's disease (HD), a neurodegenerative disorder characterized by loss of striatal neurons, is caused by an expansion of a polyglutamine tract in the HD protein huntingtin. This gene encodes a protein that interacts with huntingtin, with two cytoskeletal proteins (dynactin and pericentriolar autoantigen protein 1), and with a hepatocyte growth factor-regulated tyrosine kinase substrate. The interactions with cytoskeletal proteins and a kinase substrate suggest a role for this protein in vesicular trafficking or organelle transport. Several alternatively spliced transcript variants encoding different isoforms have been described for this gene.

Description: A Rabbit polyclonal antibody against Human Huntingtin Associated Protein 1 (HAP1). This antibody is labeled with APC-Cy7.

Description: A Rabbit polyclonal antibody against Mouse Huntingtin Associated Protein 1 (HAP1). This antibody is labeled with APC-Cy7.

Description: A Rabbit polyclonal antibody against Rat Huntingtin Associated Protein 1 (HAP1). This antibody is labeled with APC-Cy7.

Description: Description of target: Originally identified as neuronal protein that specifically associates with HTT/huntingtin and the binding is enhanced by an expanded polyglutamine repeat within HTT possibly affecting HAP1 interaction properties. Both HTT and HAP1 are involved in intracellular trafficking and HAP1 is proposed to link HTT to motor proteins and/or transport cargos. Seems to play a role in vesicular transport within neurons and axons such as from early endosomes to late endocytic compartments and to promote neurite outgrowth. The vesicular transport function via association with microtubule-dependent transporters can be attenuated by association with mutant HTT. Involved in the axonal transport of BDNF and its activity-dependent secretion; the function seems to involve HTT, DCTN1 and a complex with SORT1. Involved in APP trafficking and seems to faciltate APP anterograde transport and membrane insertion thereby possibly reducing processing into amyloid beta. Involved in delivery of gamma-aminobutyric acid (GABA(A)) receptors to synapses; the function is dependent on kinesin motor protein KIF5 and is disrupted by HTT with expanded polyglutamine repeat. Involved in regulation of autophagosome motility by promoting efficient retrograde axonal transport. Seems to be involved in regulation of membrane receptor recycling and degradation, and respective signal transduction, including GABA(A) receptors, tyrosine kinase receptors, EGFR, IP3 receptor and androgen receptor. Among others suggested to be involved in control of feeding behavior (involving hypothalamic GABA(A) receptors), cerebellar and brainstem development (involving AHI1 and NTRK1/TrkA), postnatal neurogenesis (involving hypothalamic NTRK2/TrkB), and ITPR1/InsP3R1-mediated Ca2+ release (involving HTT and possibly the effect of mutant HTT). Via association with DCTN1/dynactin p150-glued and HTT/huntingtin involved in cytoplasmic retention of REST in neurons. May be involved in ciliogenesis. Involved in regulation of exocytosis. Seems to be involved in formation of cytoplasmic inclusion bodies (STBs). In case of anomalous expression of TBP, can sequester a subset of TBP into STBs; sequestration is enhanced by an expanded polyglutamine repeat within TBP. HAP1-containing STBs have been proposed to play a protective role against neurodegeneration in Huntigton disease (HD) and spinocerebellar ataxia 17 (SCA17).1 Publication <p>Manually curated information for which there is published experimental evidence.</p> <p><a href="/manual/evidences#ECO:0000269">More…</a></p> Manual assertion based on experiment iniRef.9"Huntingtin regulates RE1-silencing transcription factor/neuron-restrictive silencer factor (REST/NRSF) nuclear trafficking indirectly through a complex with REST/NRSF-interacting LIM domain protein (RILP) and dynactin p150 Glued."_x005F_x005F_x000D_Shimojo M._x005F_x005F_x000D_J. Biol. Chem. 283:34880-34886(2008) [PubMed] [Europe PMC] [Abstract]Cited for: FUNCTION. ;Species reactivity: Human;Application: ELISA;Assay info: Assay Methodology: Quantitative Sandwich Immunoassay;Sensitivity: < 0.113 ng/mL