HAP1 Rabbit Polyclonal Antibody

HAP1 Rabbit Polyclonal Antibody

 

HAP1 Rabbit pAb

A16333-20ul Abclonal 20 ul 219.6 EUR

HAP1 Rabbit pAb

A16333-50ul Abclonal 50 ul 267.6 EUR

Human Huntingtin Associated Protein 1 (HAP1) ELISA Kit

DLR-HAP1-Hu-48T DL Develop 48T 620.4 EUR
Description: A sandwich quantitative ELISA assay kit for detection of Human Huntingtin Associated Protein 1 (HAP1) in samples from tissue homogenates or other biological fluids.

Human Huntingtin Associated Protein 1 (HAP1) ELISA Kit

DLR-HAP1-Hu-96T DL Develop 96T 807.6 EUR
Description: A sandwich quantitative ELISA assay kit for detection of Human Huntingtin Associated Protein 1 (HAP1) in samples from tissue homogenates or other biological fluids.

Human Huntingtin Associated Protein 1 (HAP1) ELISA Kit

RD-HAP1-Hu-48Tests Reddot Biotech 48 Tests 625.2 EUR

Human Huntingtin Associated Protein 1 (HAP1) ELISA Kit

RD-HAP1-Hu-96Tests Reddot Biotech 96 Tests 867.6 EUR

Human Huntingtin Associated Protein 1 (HAP1) ELISA Kit

RDR-HAP1-Hu-48Tests Reddot Biotech 48 Tests 652.8 EUR

Human Huntingtin Associated Protein 1 (HAP1) ELISA Kit

RDR-HAP1-Hu-96Tests Reddot Biotech 96 Tests 907.2 EUR

HAP1 Polyclonal Conjugated Antibody

C29811 SAB 100ul 476.4 EUR

Polyclonal HAP1 Antibody (Internal)

APR12326G Leading Biology 0.05mg 580.8 EUR
Description: A polyclonal antibody raised in Goat that recognizes and binds to Human HAP1 (Internal). This antibody is tested and proven to work in the following applications:

Polyclonal HAP1 Antibody (Internal)

APR12327G Leading Biology 0.05mg 580.8 EUR
Description: A polyclonal antibody raised in Rabbit that recognizes and binds to Human HAP1 (Internal). This antibody is tested and proven to work in the following applications:

HAP1 Antibody

1-CSB-PA010129LA01HU Cusabio
  • 380.40 EUR
  • 402.00 EUR
  • 100ul
  • 50ul
Description: A polyclonal antibody against HAP1. Recognizes HAP1 from Human. This antibody is Unconjugated. Tested in the following application: ELISA, IF; Recommended dilution: IF:1:50-1:200

HAP1 Antibody

4205-002mg ProSci 0.02 mg 206.18 EUR
Description: HAP1 Antibody: Huntington's disease (HD), a neurodegenerative disorder characterized by loss of striatal neurons, is caused by an expansion of a polyglutamine tract in the HD protein huntingtin. HAP1 was initially identified through a two-hybrid library screening; the binding of HAP1 to huntingtin correlated with the expansion of the polyglutamine tract. HAP1 also interacts with two cytoskeletal proteins (dynactin and pericentriolar autoantigen protein 1), suggesting that HAP1 may play a role in vesicular trafficking or organelle transport. HAP1 is also involved with the huntingtin-enhanced BDNF transport along the cellular microtubles. Attenuation of this process led to the loss of neurotrophic support and neuronal toxicity, which suggests that loss of this function might contribute to pathogenesis. Several alternatively spliced isoforms have been described for HAP1.

HAP1 Antibody

4205-01mg ProSci 0.1 mg 523.7 EUR
Description: HAP1 Antibody: Huntington's disease (HD), a neurodegenerative disorder characterized by loss of striatal neurons, is caused by an expansion of a polyglutamine tract in the HD protein huntingtin. HAP1 was initially identified through a two-hybrid library screening; the binding of HAP1 to huntingtin correlated with the expansion of the polyglutamine tract. HAP1 also interacts with two cytoskeletal proteins (dynactin and pericentriolar autoantigen protein 1), suggesting that HAP1 may play a role in vesicular trafficking or organelle transport. HAP1 is also involved with the huntingtin-enhanced BDNF transport along the cellular microtubles. Attenuation of this process led to the loss of neurotrophic support and neuronal toxicity, which suggests that loss of this function might contribute to pathogenesis. Several alternatively spliced isoforms have been described for HAP1.

HAP1 Antibody

24527-100ul SAB 100ul 468 EUR

Hap1 Antibody

R35211-100UG NSJ Bioreagents 100 ug 399 EUR

HAP1 Antibody

R35816-100UG NSJ Bioreagents 100 ug 399 EUR

Polyclonal Goat Anti-HAP1 Antibody

AMM05941G Leading Biology 0.1 mg 580.8 EUR
Description: A polyclonal antibody raised in Goat that recognizes and binds to Human Goat Anti-HAP1 . This antibody is tested and proven to work in the following applications:

Polyclonal HAP1 Antibody (aa639-653)

AMRa00056G Leading Biology 0.05mg 580.8 EUR
Description: A polyclonal antibody raised in Rabbit that recognizes and binds to Human HAP1 (aa639-653). This antibody is tested and proven to work in the following applications:

Hap1/ Rat Hap1 ELISA Kit

ELI-39039r Lifescience Market 96 Tests 1063.2 EUR

anti- HAP1 antibody

FNab03753 FN Test 100µg 658.5 EUR
Description: Antibody raised against HAP1

Anti-HAP1 antibody

PAab03753 Lifescience Market 100 ug 463.2 EUR

Anti-HAP1 antibody

STJ190904 St John's Laboratory 200 µl 236.4 EUR
Description: Unconjugated Rabbit polyclonal to HAP1

Anti-HAP1 antibody

STJ71050 St John's Laboratory 100 µg 430.8 EUR

Anti-HAP1 antibody

STJ118773 St John's Laboratory 100 µl 332.4 EUR

HAP1 siRNA

20-abx919071 Abbexa
  • 661.20 EUR
  • 878.40 EUR
  • 15 nmol
  • 30 nmol

HAP1 siRNA

20-abx919072 Abbexa
  • 661.20 EUR
  • 878.40 EUR
  • 15 nmol
  • 30 nmol

HAP1 Peptide

45-721P ProSci 0.1 mg 405.6 EUR
Description: (IN) HAP1 Peptide

HAP1 Peptide

45-722P ProSci 0.1 mg 405.6 EUR
Description: (CT) HAP1 (mouse) Peptide

HAP1 Peptide

4205P ProSci 0.05 mg 197.7 EUR
Description: (IN) HAP1 peptide

HAP1 siRNA

20-abx902410 Abbexa
  • 661.20 EUR
  • 878.40 EUR
  • 15 nmol
  • 30 nmol

anti-HAP1

YF-PA27427 Abfrontier 50 ug 435.6 EUR
Description: Mouse polyclonal to HAP1

Huntingtin-associated protein 1 (HAP1) polyclonal antibody

ABP-PAB-10627 Allele Biotech 100 ug Ask for price

HAP1 Antibody, HRP conjugated

1-CSB-PA010129LB01HU Cusabio
  • 380.40 EUR
  • 402.00 EUR
  • 100ul
  • 50ul
Description: A polyclonal antibody against HAP1. Recognizes HAP1 from Human. This antibody is HRP conjugated. Tested in the following application: ELISA

HAP1 Antibody, FITC conjugated

1-CSB-PA010129LC01HU Cusabio
  • 380.40 EUR
  • 402.00 EUR
  • 100ul
  • 50ul
Description: A polyclonal antibody against HAP1. Recognizes HAP1 from Human. This antibody is FITC conjugated. Tested in the following application: ELISA

HAP1 Antibody, Biotin conjugated

1-CSB-PA010129LD01HU Cusabio
  • 380.40 EUR
  • 402.00 EUR
  • 100ul
  • 50ul
Description: A polyclonal antibody against HAP1. Recognizes HAP1 from Human. This antibody is Biotin conjugated. Tested in the following application: ELISA

Anti-Hap1 (mouse) antibody

STJ71179 St John's Laboratory 100 µg 430.8 EUR

Huntingtin Associated Protein 1 (HAP1) Polyclonal Antibody (Human)

4-PAH923Hu01 Cloud-Clone
  • 296.40 EUR
  • 3012.00 EUR
  • 750.00 EUR
  • 372.00 EUR
  • 256.80 EUR
  • 100ul
  • 10ml
  • 1ml
  • 200ul
  • 20ul
Description: A Rabbit polyclonal antibody against Human Huntingtin Associated Protein 1 (HAP1)

Huntingtin Associated Protein 1 (HAP1) Polyclonal Antibody (Mouse)

4-PAH923Mu01 Cloud-Clone
  • 301.20 EUR
  • 3091.20 EUR
  • 768.00 EUR
  • 379.20 EUR
  • 258.00 EUR
  • 100ul
  • 10ml
  • 1ml
  • 200ul
  • 20ul
Description: A Rabbit polyclonal antibody against Mouse Huntingtin Associated Protein 1 (HAP1)

Huntingtin Associated Protein 1 (HAP1) Polyclonal Antibody (Rat)

4-PAH923Ra01 Cloud-Clone
  • 310.80 EUR
  • 3249.60 EUR
  • 804.00 EUR
  • 393.60 EUR
  • 262.80 EUR
  • 100ul
  • 10ml
  • 1ml
  • 200ul
  • 20ul
Description: A Rabbit polyclonal antibody against Rat Huntingtin Associated Protein 1 (HAP1)

Recombinant human HAP1

P1128 FN Test 100ug Ask for price
Description: Recombinant protein for human HAP1

Huntingtin Associated Protein 1 (HAP1) Polyclonal Antibody (Human), APC

4-PAH923Hu01-APC Cloud-Clone
  • 414.00 EUR
  • 3930.00 EUR
  • 1094.40 EUR
  • 528.00 EUR
  • 262.80 EUR
  • 100ul
  • 10ml
  • 1ml
  • 200ul
  • 20ul
Description: A Rabbit polyclonal antibody against Human Huntingtin Associated Protein 1 (HAP1). This antibody is labeled with APC.

Huntingtin Associated Protein 1 (HAP1) Polyclonal Antibody (Human), Biotinylated

4-PAH923Hu01-Biotin Cloud-Clone
  • 373.20 EUR
  • 2952.00 EUR
  • 872.40 EUR
  • 457.20 EUR
  • 262.80 EUR
  • 100ul
  • 10ml
  • 1ml
  • 200ul
  • 20ul
Description: A Rabbit polyclonal antibody against Human Huntingtin Associated Protein 1 (HAP1). This antibody is labeled with Biotin.

Huntingtin Associated Protein 1 (HAP1) Polyclonal Antibody (Human), Cy3

4-PAH923Hu01-Cy3 Cloud-Clone
  • 502.80 EUR
  • 5190.00 EUR
  • 1410.00 EUR
  • 654.00 EUR
  • 301.20 EUR
  • 100ul
  • 10ml
  • 1ml
  • 200ul
  • 20ul
Description: A Rabbit polyclonal antibody against Human Huntingtin Associated Protein 1 (HAP1). This antibody is labeled with Cy3.

Huntingtin Associated Protein 1 (HAP1) Polyclonal Antibody (Human), FITC

4-PAH923Hu01-FITC Cloud-Clone
  • 355.20 EUR
  • 3168.00 EUR
  • 900.00 EUR
  • 446.40 EUR
  • 234.00 EUR
  • 100ul
  • 10ml
  • 1ml
  • 200ul
  • 20ul
Description: A Rabbit polyclonal antibody against Human Huntingtin Associated Protein 1 (HAP1). This antibody is labeled with FITC.

Huntingtin Associated Protein 1 (HAP1) Polyclonal Antibody (Human), HRP

4-PAH923Hu01-HRP Cloud-Clone
  • 379.20 EUR
  • 3426.00 EUR
  • 968.40 EUR
  • 477.60 EUR
  • 247.20 EUR
  • 100ul
  • 10ml
  • 1ml
  • 200ul
  • 20ul
Description: A Rabbit polyclonal antibody against Human Huntingtin Associated Protein 1 (HAP1). This antibody is labeled with HRP.

Huntingtin Associated Protein 1 (HAP1) Polyclonal Antibody (Human), PE

4-PAH923Hu01-PE Cloud-Clone
  • 355.20 EUR
  • 3168.00 EUR
  • 900.00 EUR
  • 446.40 EUR
  • 234.00 EUR
  • 100ul
  • 10ml
  • 1ml
  • 200ul
  • 20ul
Description: A Rabbit polyclonal antibody against Human Huntingtin Associated Protein 1 (HAP1). This antibody is labeled with PE.

Huntingtin Associated Protein 1 (HAP1) Polyclonal Antibody (Mouse), APC

4-PAH923Mu01-APC Cloud-Clone
  • 421.20 EUR
  • 4038.00 EUR
  • 1122.00 EUR
  • 538.80 EUR
  • 266.40 EUR
  • 100ul
  • 10ml
  • 1ml
  • 200ul
  • 20ul
Description: A Rabbit polyclonal antibody against Mouse Huntingtin Associated Protein 1 (HAP1). This antibody is labeled with APC.

Huntingtin Associated Protein 1 (HAP1) Polyclonal Antibody (Mouse), Biotinylated

4-PAH923Mu01-Biotin Cloud-Clone
  • 379.20 EUR
  • 3031.20 EUR
  • 892.80 EUR
  • 464.40 EUR
  • 265.20 EUR
  • 100ul
  • 10ml
  • 1ml
  • 200ul
  • 20ul
Description: A Rabbit polyclonal antibody against Mouse Huntingtin Associated Protein 1 (HAP1). This antibody is labeled with Biotin.

Huntingtin Associated Protein 1 (HAP1) Polyclonal Antibody (Mouse), Cy3

4-PAH923Mu01-Cy3 Cloud-Clone
  • 512.40 EUR
  • 5334.00 EUR
  • 1446.00 EUR
  • 668.40 EUR
  • 304.80 EUR
  • 100ul
  • 10ml
  • 1ml
  • 200ul
  • 20ul
Description: A Rabbit polyclonal antibody against Mouse Huntingtin Associated Protein 1 (HAP1). This antibody is labeled with Cy3.

Huntingtin Associated Protein 1 (HAP1) Polyclonal Antibody (Mouse), FITC

4-PAH923Mu01-FITC Cloud-Clone
  • 361.20 EUR
  • 3254.40 EUR
  • 921.60 EUR
  • 454.80 EUR
  • 236.40 EUR
  • 100ul
  • 10ml
  • 1ml
  • 200ul
  • 20ul
Description: A Rabbit polyclonal antibody against Mouse Huntingtin Associated Protein 1 (HAP1). This antibody is labeled with FITC.

Huntingtin Associated Protein 1 (HAP1) Polyclonal Antibody (Mouse), HRP

4-PAH923Mu01-HRP Cloud-Clone
  • 385.20 EUR
  • 3519.60 EUR
  • 992.40 EUR
  • 486.00 EUR
  • 250.80 EUR
  • 100ul
  • 10ml
  • 1ml
  • 200ul
  • 20ul
Description: A Rabbit polyclonal antibody against Mouse Huntingtin Associated Protein 1 (HAP1). This antibody is labeled with HRP.

Huntingtin Associated Protein 1 (HAP1) Polyclonal Antibody (Mouse), PE

4-PAH923Mu01-PE Cloud-Clone
  • 361.20 EUR
  • 3254.40 EUR
  • 921.60 EUR
  • 454.80 EUR
  • 236.40 EUR
  • 100ul
  • 10ml
  • 1ml
  • 200ul
  • 20ul
Description: A Rabbit polyclonal antibody against Mouse Huntingtin Associated Protein 1 (HAP1). This antibody is labeled with PE.

Huntingtin Associated Protein 1 (HAP1) Polyclonal Antibody (Rat), APC

4-PAH923Ra01-APC Cloud-Clone
  • 436.80 EUR
  • 4254.00 EUR
  • 1176.00 EUR
  • 560.40 EUR
  • 272.40 EUR
  • 100ul
  • 10ml
  • 1ml
  • 200ul
  • 20ul
Description: A Rabbit polyclonal antibody against Rat Huntingtin Associated Protein 1 (HAP1). This antibody is labeled with APC.

Huntingtin Associated Protein 1 (HAP1) Polyclonal Antibody (Rat), Biotinylated

4-PAH923Ra01-Biotin Cloud-Clone
  • 390.00 EUR
  • 3189.60 EUR
  • 932.40 EUR
  • 480.00 EUR
  • 270.00 EUR
  • 100ul
  • 10ml
  • 1ml
  • 200ul
  • 20ul
Description: A Rabbit polyclonal antibody against Rat Huntingtin Associated Protein 1 (HAP1). This antibody is labeled with Biotin.

Huntingtin Associated Protein 1 (HAP1) Polyclonal Antibody (Rat), Cy3

4-PAH923Ra01-Cy3 Cloud-Clone
  • 532.80 EUR
  • 5622.00 EUR
  • 1518.00 EUR
  • 697.20 EUR
  • 313.20 EUR
  • 100ul
  • 10ml
  • 1ml
  • 200ul
  • 20ul
Description: A Rabbit polyclonal antibody against Rat Huntingtin Associated Protein 1 (HAP1). This antibody is labeled with Cy3.

Huntingtin Associated Protein 1 (HAP1) Polyclonal Antibody (Rat), FITC

4-PAH923Ra01-FITC Cloud-Clone
  • 373.20 EUR
  • 3427.20 EUR
  • 964.80 EUR
  • 471.60 EUR
  • 242.40 EUR
  • 100ul
  • 10ml
  • 1ml
  • 200ul
  • 20ul
Description: A Rabbit polyclonal antibody against Rat Huntingtin Associated Protein 1 (HAP1). This antibody is labeled with FITC.

Huntingtin Associated Protein 1 (HAP1) Polyclonal Antibody (Rat), HRP

4-PAH923Ra01-HRP Cloud-Clone
  • 398.40 EUR
  • 3706.80 EUR
  • 1039.20 EUR
  • 505.20 EUR
  • 255.60 EUR
  • 100ul
  • 10ml
  • 1ml
  • 200ul
  • 20ul
Description: A Rabbit polyclonal antibody against Rat Huntingtin Associated Protein 1 (HAP1). This antibody is labeled with HRP.

Huntingtin Associated Protein 1 (HAP1) Polyclonal Antibody (Rat), PE

4-PAH923Ra01-PE Cloud-Clone
  • 373.20 EUR
  • 3427.20 EUR
  • 964.80 EUR
  • 471.60 EUR
  • 242.40 EUR
  • 100ul
  • 10ml
  • 1ml
  • 200ul
  • 20ul
Description: A Rabbit polyclonal antibody against Rat Huntingtin Associated Protein 1 (HAP1). This antibody is labeled with PE.

Rat HAP1 shRNA Plasmid

20-abx985492 Abbexa
  • 961.20 EUR
  • 1345.20 EUR
  • 150 µg
  • 300 µg

Human HAP1 shRNA Plasmid

20-abx955940 Abbexa
  • 961.20 EUR
  • 1345.20 EUR
  • 150 µg
  • 300 µg

Mouse HAP1 shRNA Plasmid

20-abx970748 Abbexa
  • 961.20 EUR
  • 1345.20 EUR
  • 150 µg
  • 300 µg

HAP1 ELISA KIT|Human

EF010059 Lifescience Market 96 Tests 826.8 EUR

HAP1 Recombinant Protein (Rat)

RP204185 ABM 100 ug Ask for price

HAP1 Recombinant Protein (Rat)

RP204188 ABM 100 ug Ask for price

HAP1 Recombinant Protein (Human)

RP061680 ABM 100 ug Ask for price

HAP1 Recombinant Protein (Mouse)

RP140906 ABM 100 ug Ask for price

HAP1 Recombinant Protein (Mouse)

RP140909 ABM 100 ug Ask for price

Huntingtin Associated Protein 1 (HAP1) Antibody

20-abx172842 Abbexa
  • 1028.40 EUR
  • 526.80 EUR
  • 1 mg
  • 200 ug

Huntingtin Associated Protein 1 (HAP1) Antibody

20-abx130407 Abbexa
  • 543.60 EUR
  • 159.60 EUR
  • 1562.40 EUR
  • 744.00 EUR
  • 410.40 EUR
  • 100 ug
  • 10 ug
  • 1 mg
  • 200 ug
  • 50 ug

Huntingtin Associated Protein 1 (HAP1) Antibody

20-abx128157 Abbexa
  • 510.00 EUR
  • 159.60 EUR
  • 1446.00 EUR
  • 693.60 EUR
  • 393.60 EUR
  • 100 ug
  • 10 ug
  • 1 mg
  • 200 ug
  • 50 ug

Huntingtin Associated Protein 1 (HAP1) Antibody

20-abx129795 Abbexa
  • 526.80 EUR
  • 159.60 EUR
  • 1479.60 EUR
  • 710.40 EUR
  • 393.60 EUR
  • 100 ug
  • 10 ug
  • 1 mg
  • 200 ug
  • 50 ug

Huntingtin Associated Protein 1 (HAP1) Antibody

abx233753-100ug Abbexa 100 ug 610.8 EUR

Huntingtin Associated Protein 1 (Hap1) Antibody

abx431315-200ul Abbexa 200 ul 460.8 EUR

Huntingtin Associated Protein 1 (HAP1) Antibody

abx432785-200ul Abbexa 200 ul 460.8 EUR

Huntingtin-associated protein 1 Antibody / HAP1

RQ6318 NSJ Bioreagents 100 ug 419 EUR
Description: Huntingtin-associated protein 1 (HAP1) is a protein which in humans is encoded by the HAP1 gene. Huntington's disease (HD), a neurodegenerative disorder characterized by loss of striatal neurons, is caused by an expansion of a polyglutamine tract in the HD protein huntingtin. This gene encodes a protein that interacts with huntingtin, with two cytoskeletal proteins (dynactin and pericentriolar autoantigen protein 1), and with a hepatocyte growth factor-regulated tyrosine kinase substrate. The interactions with cytoskeletal proteins and a kinase substrate suggest a role for this protein in vesicular trafficking or organelle transport. Several alternatively spliced transcript variants encoding different isoforms have been described for this gene.

Huntingtin Associated Protein 1 (HAP1) Polyclonal Antibody (Human), APC-Cy7

4-PAH923Hu01-APC-Cy7 Cloud-Clone
  • 685.20 EUR
  • 7716.00 EUR
  • 2046.00 EUR
  • 912.00 EUR
  • 382.80 EUR
  • 100ul
  • 10ml
  • 1ml
  • 200ul
  • 20ul
Description: A Rabbit polyclonal antibody against Human Huntingtin Associated Protein 1 (HAP1). This antibody is labeled with APC-Cy7.

Huntingtin Associated Protein 1 (HAP1) Polyclonal Antibody (Mouse), APC-Cy7

4-PAH923Mu01-APC-Cy7 Cloud-Clone
  • 699.60 EUR
  • 7932.00 EUR
  • 2100.00 EUR
  • 933.60 EUR
  • 388.80 EUR
  • 100ul
  • 10ml
  • 1ml
  • 200ul
  • 20ul
Description: A Rabbit polyclonal antibody against Mouse Huntingtin Associated Protein 1 (HAP1). This antibody is labeled with APC-Cy7.

Huntingtin Associated Protein 1 (HAP1) Polyclonal Antibody (Rat), APC-Cy7

4-PAH923Ra01-APC-Cy7 Cloud-Clone
  • 729.60 EUR
  • 8364.00 EUR
  • 2208.00 EUR
  • 976.80 EUR
  • 402.00 EUR
  • 100ul
  • 10ml
  • 1ml
  • 200ul
  • 20ul
Description: A Rabbit polyclonal antibody against Rat Huntingtin Associated Protein 1 (HAP1). This antibody is labeled with APC-Cy7.

HAP1 ELISA Kit (Human) (OKCD01042)

OKCD01042 Aviva Systems Biology 96 Wells 997.2 EUR
Description: Description of target: Originally identified as neuronal protein that specifically associates with HTT/huntingtin and the binding is enhanced by an expanded polyglutamine repeat within HTT possibly affecting HAP1 interaction properties. Both HTT and HAP1 are involved in intracellular trafficking and HAP1 is proposed to link HTT to motor proteins and/or transport cargos. Seems to play a role in vesicular transport within neurons and axons such as from early endosomes to late endocytic compartments and to promote neurite outgrowth. The vesicular transport function via association with microtubule-dependent transporters can be attenuated by association with mutant HTT. Involved in the axonal transport of BDNF and its activity-dependent secretion; the function seems to involve HTT, DCTN1 and a complex with SORT1. Involved in APP trafficking and seems to faciltate APP anterograde transport and membrane insertion thereby possibly reducing processing into amyloid beta. Involved in delivery of gamma-aminobutyric acid (GABA(A)) receptors to synapses; the function is dependent on kinesin motor protein KIF5 and is disrupted by HTT with expanded polyglutamine repeat. Involved in regulation of autophagosome motility by promoting efficient retrograde axonal transport. Seems to be involved in regulation of membrane receptor recycling and degradation, and respective signal transduction, including GABA(A) receptors, tyrosine kinase receptors, EGFR, IP3 receptor and androgen receptor. Among others suggested to be involved in control of feeding behavior (involving hypothalamic GABA(A) receptors), cerebellar and brainstem development (involving AHI1 and NTRK1/TrkA), postnatal neurogenesis (involving hypothalamic NTRK2/TrkB), and ITPR1/InsP3R1-mediated Ca2+ release (involving HTT and possibly the effect of mutant HTT). Via association with DCTN1/dynactin p150-glued and HTT/huntingtin involved in cytoplasmic retention of REST in neurons. May be involved in ciliogenesis. Involved in regulation of exocytosis. Seems to be involved in formation of cytoplasmic inclusion bodies (STBs). In case of anomalous expression of TBP, can sequester a subset of TBP into STBs; sequestration is enhanced by an expanded polyglutamine repeat within TBP. HAP1-containing STBs have been proposed to play a protective role against neurodegeneration in Huntigton disease (HD) and spinocerebellar ataxia 17 (SCA17).1 Publication <p>Manually curated information for which there is published experimental evidence.</p> <p><a href="/manual/evidences#ECO:0000269">More…</a></p> Manual assertion based on experiment iniRef.9"Huntingtin regulates RE1-silencing transcription factor/neuron-restrictive silencer factor (REST/NRSF) nuclear trafficking indirectly through a complex with REST/NRSF-interacting LIM domain protein (RILP) and dynactin p150 Glued."_x005F_x005F_x000D_Shimojo M._x005F_x005F_x000D_J. Biol. Chem. 283:34880-34886(2008) [PubMed] [Europe PMC] [Abstract]Cited for: FUNCTION. ;Species reactivity: Human;Application: ELISA;Assay info: Assay Methodology: Quantitative Sandwich Immunoassay;Sensitivity: < 0.113 ng/mL

Hap1 ORF Vector (Rat) (pORF)

ORF068063 ABM 1.0 ug DNA 607.2 EUR

HAP1 Rabbit Polyclonal Antibody

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