Parenchymal brain metastases from prostate most cancers are uncommon and largely seem within the terminal section of the illness. Here, we report a case of cystic cerebral metastases in affected person with prostate adenocarcinoma.
This affected person introduced with one massive parietal polycystic tumor and three different suspicious-looking nodular lesions as proven on magnetic resonance imaging.
This is the twelfth reported case of prostatic brain metastasis occurring as a cystic intraparenchymal tumor within the literature.
The Value of Tumor Treating Fields in Glioblastoma.
Glioblastoma (GBM) is among the most typical tumors of the central nervous system, which is essentially the most deadly brain most cancers.
GBM remedy is predicated totally on surgical resection, mixed with radiotherapy and chemotherapy. Despite the constructive remedy, development free survival and total survival weren’t considerably extended as a result of GBM virtually all the time recurs.
We are all the time trying ahead to some new and efficient therapies. In latest years, a novel remedy technique referred to as tumor treating fields (TTFields) for most cancers remedy has been proposed.
TTFields gadgets have been accepted by the Food and Drug Administration (FDA) for adjuvant remedy of recurrent and newly recognized GBMs in 2011 and 2015, respectively.
This turned the primary breakthrough remedy for GBM up to now 10 years after the FDA accepted bevacizumab for sufferers with relapsed GBM in 2009. This paper summarized the analysis outcomes of TTFields lately and elaborated the mechanism of motion of TTFields on GBM, together with cell and animal experimental analysis, scientific software and social advantages.
Development and preliminary analysis of a novel simulation mannequin for complete brain tumor surgical procedure coaching.
Increasing technico-manual complexity of procedures and time constraints necessitates efficient neurosurgical coaching. For this goal, each screen- and model-based simulations are underneath investigation. Approaches together with 3D printed brains, gelatin composite fashions, and digital environments have already been revealed.
However, high quality of brain surgical procedure simulation is proscribed resulting from discrepancies in visible and haptic expertise. Similarly, digital coaching situations are nonetheless missing ample real-world resemblance. In this research, we introduce a novel simulator for life like neurosurgical coaching that combines actual brain tissue with 3D printing and augmented actuality.
Based on a human CT scan, a cranium base and skullcap have been 3D printed and outfitted with a synthetic dura mater. The cerebral hemispheres of a calf’s brain have been positioned within the convexity of the skullcap and tumor plenty composed of aspic, water, and fluorescein have been injected within the brain. The skullcap and cranium base have been positioned on one another, glued collectively, and crammed up with an aspic water answer for brain fixation. Then, 4 surgical situations have been carried out within the working room as follows: (1) easy tumor resection, (2) advanced tumor resection, (3) navigated biopsy through burr gap trepanation, and (4) retrosigmoidal craniotomy. Neuronavigation, augmented actuality, fluorescence, and ocular-as nicely as screen-based (exoscopic)-surgery have been accessible for the simulator coaching. A complete of 29 individuals carried out at the least one coaching state of affairs of the simulator and accomplished a 5-item Likert-like questionnaire in addition to qualitative interviews.
The questionnaire assessed the realism of the tumor mannequin, cranium, and brain tissue in addition to the aptitude for coaching functions.Visual and sensory realism of the cranium and brain tissue have been rated,”excellent,” whereas the sensory and visible realism of the tumor mannequin have been rated “good.” Both total satisfaction with the mannequin and eligibility of the microscope and neurosurgical devices for coaching functions have been rated with “excellent.” However, small measurement of the calf’s brain, its restricted shelf life, and the lack to simulate bleedings because of the lack of perfusion have been vital drawbacks.
The mixture of 3D printing and actual brain tissue supplied surgical situations with excellent real-life resemblance. This novel neurosurgical mannequin contains a versatile setup for surgical ability coaching and permits for environment friendly coaching of technological assist like picture and fluorescence steerage, exoscopic surgical procedure, and robotic know-how.